Evidence map›Paper›PMID 27041111›Full record

SynthesisClinical oral investigations2016

Soft tissue augmentation procedures at second-stage surgery: a systematic review.

Renzo G Bassetti, Alexandra Stähli, Mario A Bassetti, Anton Sculean

Registry-linked trialAbstract readSystematic Review
PubMed Publisher
In one paragraph

Synthesis in Clinical oral investigations, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07330609 (Clinical, Radiographic, and Digital Evaluation of the Effects of Autogenous Grafts Harvested From Different Palatal Sites and Applied During Second-stage Implant Surgery on the Peri-implant Mucosa), which is not on this map. Cited by 32 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed, 7 pooled it
9.1field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07330609 narecruitingnot on this mapstarted 2026, after this paper: background citation

Clinical, Radiographic, and Digital Evaluation of the Effects of Autogenous Grafts Harvested From Different Palatal Sites and Applied During Second-stage Implant Surgery on the Peri-implant Mucosa

TypeinterventionalSponsorKutahya Health Sciences UniversityRan2026 to 2027Enrolled30ConditionsPeri-implant Health, Free Gingival Graft, Peri-implant MucositisArmsCoronal palatal tissue, Apical palatal tissue
3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 7 syntheses or guidelines pooled it, 88 citations in OpenAlex.

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  2. Timing of keratinized mucosa augmentation and peri-implant outcomes: A systematic review and meta-analysis.Journal of prosthodontics : official journal of the American College of Prosthodontists · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Renzo G BassettiDepartment of Oral and Maxillofacial Surgery, Lucerne Cantonal Hospital, Spitalstrasse, 6000, Lucerne, Switzerland. renzo.bassetti@luks.ch.
Alexandra StähliDepartment of Periodontology, University of Bern, Bern, Switzerland.
Mario A BassettiDepartment of Periodontology, University of Bern, Bern, Switzerland.
Anton SculeanDepartment of Periodontology, University of Bern, Bern, Switzerland.
University of Bern · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesThe aim of this systematic review was to evaluate the efficacy of different soft tissue augmentation/correction methods in terms of increasing the peri-implant width of keratinized mucosa (KM) and/or gain of soft tissue volume during second-stage surgery. MATERIALS AND

methodsScreening of two databases, MEDLINE (PubMed) and EMBASE (OVID), and hand search of related articles, were performed. Human studies reporting on soft tissue augmentation/correction methods around submucosally osseointegrated implants during second-stage surgery up to July 31, 2015 were considered. Quality assessment of the selected full-text articles was performed according to the Cochrane collaboration's tool to assess the risk of bias.

resultsOverall, eight prospective studies (risk of bias: high) and two case series (risk of bias: high) were included. Depending on the surgical technique and graft material used, the enlargement of keratinized tissue (KT) ranged between -0.20 and 9.35 mm. An apically positioned partial-thickness flap/vestibuloplasty (APPTF/VP) in combination with a free gingival graft (FGG) or a xenogeneic graft material (XCM) was most effective. Applying a roll envelope flap (REF) or an APPTF in combination with a subepithelial connective tissue graft (SCTG), mean increases in soft tissue volumes of 2.41 and 3.10 mm, respectively, were achieved. Due to the heterogeneity of study designs, no meta-analysis could be performed.

conclusionsWithin the limitations of this review, regarding the enlargement of peri-implant KT, the APPTF in the maxilla and the APPTF/VP in combination with FGG or XCM in the lower and upper jaw seem to provide acceptable outcomes. To augment peri-implant soft tissue volume REF in the maxilla or APPTF + SCTG in the lower and upper jaw appear to be reliable treatment options. CLINICAL RELEVANCE: The localization in the jaw and the clinical situation are crucial for the decision which second-stage procedure should be applied.

Indexed as

Dental ImplantsConnective TissueGingivaGingivoplastyHumansJaw, Edentulous, PartiallySurgical FlapsVestibuloplastyDental ImplantsPeri-implant keratinized mucosaPeri-implant soft tissue volumeRe-entrySecond-stage surgery

Identifiers

PMID27041111
OpenAlexW2339583294

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.