Evidence map›Paper›PMID 27040690›Full record

SynthesisAmerican journal of human genetics2016

DNA Methylation in Newborns and Maternal Smoking in Pregnancy: Genome-wide Consortium Meta-analysis.

Bonnie R Joubert, Janine F Felix, Paul Yousefi, Kelly M Bakulski, Allan C Just, Carrie Breton, Sarah E Reese, Christina A Markunas, Rebecca C Richmond, Cheng-Jian Xu and 96 more

Open access · bronzeAbstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in American journal of human genetics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 537 papers, 14 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
537citing papers in PubMed, 14 pooled it
58.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

537 citing papers in PubMed, 14 syntheses or guidelines pooled it, 909 citations in OpenAlex.

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477 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

106 authors at 20 institutions in 9 countries.

Bonnie R JoubertNational Institute of Environmental Health Sciences, NIH, U.S. Department of Health and Human Services, Research Triangle Park, NC 27709, USA.
Janine F FelixDepartment of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam 3000 CA, the Netherlands; Department of Pediatrics, Erasmus MC, University Medical Center Rotterdam, Rotterdam 3000 CA, the Netherlands; The Generation R Study Group, Erasmus MC, University Medical Center Rotterdam, Rotterdam, 3000 CA the Netherlands.
Paul YousefiCenter for Environmental Research and Children's Health (CERCH), School of Public Health, University of California Berkeley, Berkeley, CA 94720-7360, USA.
Kelly M BakulskiBloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21205, USA.
Allan C JustDepartment of Preventive Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Carrie BretonUniversity of Southern California, Los Angeles, CA 90032, USA.
Sarah E ReeseNational Institute of Environmental Health Sciences, NIH, U.S. Department of Health and Human Services, Research Triangle Park, NC 27709, USA.
Christina A MarkunasNational Institute of Environmental Health Sciences, NIH, U.S. Department of Health and Human Services, Research Triangle Park, NC 27709, USA; Duke Molecular Physiology Institute, Duke University Medical Center, Durham, NC 27710, USA.
Rebecca C RichmondMRC Integrative Epidemiology Unit, School of Social and Community Medicine, University of Bristol, Bristol BS8 2BN, UK.
Cheng-Jian XuDepartment of Genetics, University of Groningen, University Medical Center Groningen, Groningen 9700 RB, the Netherlands; Department of Pulmonology, University of Groningen, University Medical Center Groningen, Groningen 9700 RB, the Netherlands; GRIAC Research Institute Groningen, University of Groningen, University Medical Center Groningen, 9700 RB, the Netherlands.
Leanne K KüpersDepartment of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen 9700 RB, the Netherlands.
Sam S OhDepartment of Medicine, University of California, San Francisco, San Francisco, CA 94143-2911, USA.
Cathrine HoyoDepartment of Biological Sciences and Center for Human Health and the Environment, North Carolina State University, Raleigh, NC 27695-7633, USA.
Olena GruzievaInstitute of Environmental Medicine, Karolinska Institutet, Stockholm 171 77, Sweden.
Cilla SöderhällDepartment of Biosciences and Nutrition, Karolinska Institutet, Stockholm 141 83, Sweden.
Lucas A SalasCentre for Research in Environmental Epidemiology (CREAL), Barcelona 08003, Spain; CIBER Epidemiología y Salud Pública (CIBERESP), Barcelona 08003, Spain; Universitat Pompeu Fabra (UPF), Barcelona 08003, Spain.
Nour BaïzSorbonne Universités, UPMC Univ Paris 06, INSERM, Pierre Louis Institute of Epidemiology and Public Health (IPLESP UMRS 1136), Epidemiology of Allergic and Respiratory Diseases Department (EPAR), Saint-Antoine Medical School, F75012 Paris, France.
Hongmei ZhangDivision of Epidemiology, Biostatistics, and Environmental Health, School of Public Health, University of Memphis, Memphis, TN 38152, USA.
Johanna LepeuleTeam of Environmental Epidemiology applied to Reproduction and Respiratory Health, Institut Albert Bonniot, Institut National de la Santé et de le Recherche Médicale, University of Grenoble Alpes, Centre Hospitalier Universitaire de Grenoble, F-38000 Grenoble, France.
Carlos RuizCentre for Research in Environmental Epidemiology (CREAL), Barcelona 08003, Spain; CIBER Epidemiología y Salud Pública (CIBERESP), Barcelona 08003, Spain; Universitat Pompeu Fabra (UPF), Barcelona 08003, Spain.
Symen LigthartDepartment of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam 3000 CA, the Netherlands.
Tianyuan WangNational Institute of Environmental Health Sciences, NIH, U.S. Department of Health and Human Services, Research Triangle Park, NC 27709, USA.
Jack A TaylorNational Institute of Environmental Health Sciences, NIH, U.S. Department of Health and Human Services, Research Triangle Park, NC 27709, USA.
Liesbeth DuijtsDepartment of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam 3000 CA, the Netherlands; The Generation R Study Group, Erasmus MC, University Medical Center Rotterdam, Rotterdam, 3000 CA the Netherlands; Division of Neonatology, Department of Pediatrics, Erasmus MC, University Medical Center Rotterdam, Rotterdam, 3000 CA, the Netherlands; Division of Respiratory Medicine, Department of Pediatrics, Erasmus MC, University Medical Center Rotterdam, Rotterdam, 3000 CA, the Netherlands.
Gemma C SharpMRC Integrative Epidemiology Unit, School of Social and Community Medicine, University of Bristol, Bristol BS8 2BN, UK.
Soesma A JankipersadsingDepartment of Genetics, University of Groningen, University Medical Center Groningen, Groningen 9700 RB, the Netherlands; Department of Pulmonology, University of Groningen, University Medical Center Groningen, Groningen 9700 RB, the Netherlands.
Roy M NilsenDepartment of Global Public Health and Primary Care, University of Bergen, Bergen 5018, Norway.
Ahmad VaezDepartment of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen 9700 RB, the Netherlands; School of Medicine, Isfahan University of Medical Sciences, Isfahan 81746-73461, Iran.
M Daniele FallinBloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21205, USA.
Donglei HuDepartment of Medicine, University of California, San Francisco, San Francisco, CA 94143-2911, USA.
Augusto A LitonjuaChanning Division of Network Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA.
Bernard F FuemmelerDepartment of Community and Family Medicine, Duke University School of Medicine, Durham, NC 27710, USA.
Karen HuenCenter for Environmental Research and Children's Health (CERCH), School of Public Health, University of California Berkeley, Berkeley, CA 94720-7360, USA.
Juha KereDepartment of Biosciences and Nutrition, Karolinska Institutet, Stockholm 141 83, Sweden.
Inger KullInstitute of Environmental Medicine, Karolinska Institutet, Stockholm 171 77, Sweden.
Monica Cheng Munthe-KaasDepartment of Pediatrics, Oslo University Hospital, Oslo 424, Norway.
Ulrike GehringInstitute for Risk Assessment Sciences, Utrecht University, Utrecht 3508 TD, the Netherlands.
Mariona BustamanteCentre for Research in Environmental Epidemiology (CREAL), Barcelona 08003, Spain; CIBER Epidemiología y Salud Pública (CIBERESP), Barcelona 08003, Spain; Universitat Pompeu Fabra (UPF), Barcelona 08003, Spain; Center for Genomic Regulation (CRG), Barcelona 08003, Spain.
Marie José Saurel-CoubizollesINSERM, Epidemiological Research Unit on Perinatal Health and Women's and Children's Health, 75654 Paris, France.
Bilal M QuraishiDivision of Epidemiology, Biostatistics, and Environmental Health, School of Public Health, University of Memphis, Memphis, TN 38152, USA.
Jie RenUniversity of Southern California, Los Angeles, CA 90032, USA.
Jörg TostLaboratory for Epigenetics and Environment, Centre National de Génotypage, CEA-Institut de Génomique, 91000 Evry, France.
Juan R GonzalezCentre for Research in Environmental Epidemiology (CREAL), Barcelona 08003, Spain; CIBER Epidemiología y Salud Pública (CIBERESP), Barcelona 08003, Spain; Universitat Pompeu Fabra (UPF), Barcelona 08003, Spain.
Marjolein J PetersDepartment of Internal Medicine, Erasmus MC, University Medical Center Rotterdam, Rotterdam, 3000 CA, the Netherlands.
Siri E HåbergDivision of Mental and Physical Health, Norwegian Institute of Public Health, Oslo 0403, Norway.
Zongli XuNational Institute of Environmental Health Sciences, NIH, U.S. Department of Health and Human Services, Research Triangle Park, NC 27709, USA.
Joyce B van MeursDepartment of Internal Medicine, Erasmus MC, University Medical Center Rotterdam, Rotterdam, 3000 CA, the Netherlands.
Tom R GauntMRC Integrative Epidemiology Unit, School of Social and Community Medicine, University of Bristol, Bristol BS8 2BN, UK.
Marjan KerkhofGRIAC Research Institute Groningen, University of Groningen, University Medical Center Groningen, 9700 RB, the Netherlands.
Eva CorpeleijnDepartment of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen 9700 RB, the Netherlands.
Andrew P FeinbergJohns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Celeste EngDepartment of Medicine, University of California, San Francisco, San Francisco, CA 94143-2911, USA.
Andrea A BaccarelliDepartment of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA.
Sara E Benjamin NeelonBloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21205, USA.
Asa BradmanCenter for Environmental Research and Children's Health (CERCH), School of Public Health, University of California Berkeley, Berkeley, CA 94720-7360, USA.
Simon Kebede MeridInstitute of Environmental Medicine, Karolinska Institutet, Stockholm 171 77, Sweden.
Anna BergströmInstitute of Environmental Medicine, Karolinska Institutet, Stockholm 171 77, Sweden.
Zdenko HercegEpigenetics Group, International Agency for Research on Cancer (IARC), 69008 Lyon, France.
Hector Hernandez-VargasEpigenetics Group, International Agency for Research on Cancer (IARC), 69008 Lyon, France.
Bert BrunekreefInstitute for Risk Assessment Sciences, Utrecht University, Utrecht 3508 TD, the Netherlands; Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht 3508 TD, the Netherlands.
Mariona PinartCentre for Research in Environmental Epidemiology (CREAL), Barcelona 08003, Spain; CIBER Epidemiología y Salud Pública (CIBERESP), Barcelona 08003, Spain; Universitat Pompeu Fabra (UPF), Barcelona 08003, Spain; Hospital del Mar Medical Research Institute (IMIM), Barcelona 08003, Spain.
Barbara HeudeINSERM, UMR 1153, Early Origin of the Child's Health And Development (ORCHAD) Team, Centre de Recherche Épidémiologie et Statistique Sorbonne Paris Cité (CRESS), Université Paris Descartes, 94807 Villejuif, France.
Susan EwartDepartment of Large Animal Clinical Sciences, Michigan State University, East Lansing, MI 48824, USA.
Jin YaoUniversity of Southern California, Los Angeles, CA 90032, USA.
Nathanaël LemonnierCentre National de la Recherche Scientifique-École Normale Supérieure de Lyon-Université Claude Bernard (Lyon 1), Université de Lyon, European Institute for Systems Biology and Medicine 69007 Lyon, France.
Oscar H FrancoDepartment of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam 3000 CA, the Netherlands.
Michael C WuFred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.
Albert HofmanDepartment of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam 3000 CA, the Netherlands; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA.
Wendy McArdleSchool of Social and Community Medicine, University of Bristol, Bristol BS8 2BN, UK.
Pieter Van der VliesDepartment of Genetics, University of Groningen, University Medical Center Groningen, Groningen 9700 RB, the Netherlands.
Fahimeh FalahiDepartment of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen 9700 RB, the Netherlands.
Matthew W GillmanObesity Prevention Program, Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, MA 02215, USA.
Lisa F BarcellosCenter for Environmental Research and Children's Health (CERCH), School of Public Health, University of California Berkeley, Berkeley, CA 94720-7360, USA.
Ashish KumarInstitute of Environmental Medicine, Karolinska Institutet, Stockholm 171 77, Sweden; Department of Public Health Epidemiology, Unit of Chronic Disease Epidemiology, Swiss Tropical and Public Health Institute, Basel 4051, Switzerland; University of Basel, Basel 4001, Switzerland.
Magnus WickmanInstitute of Environmental Medicine, Karolinska Institutet, Stockholm 171 77, Sweden; Sachs' Children's Hospital and Centre for Occupational and Environmental Medicine, Stockholm County Council, Stockholm 171 77, Sweden.
Stefano GuerraCentre for Research in Environmental Epidemiology (CREAL), Barcelona 08003, Spain.
Marie-Aline CharlesINSERM, UMR 1153, Early Origin of the Child's Health And Development (ORCHAD) Team, Centre de Recherche Épidémiologie et Statistique Sorbonne Paris Cité (CRESS), Université Paris Descartes, 94807 Villejuif, France.
John HollowayFaculty of Medicine, Clinical & Experimental Sciences, University of Southampton, Southampton SO16 6YD, UK; Faculty of Medicine, Human Development & Health, University of Southampton, Southampton SO16 6YD, UK.
Charles AuffrayCentre National de la Recherche Scientifique-École Normale Supérieure de Lyon-Université Claude Bernard (Lyon 1), Université de Lyon, European Institute for Systems Biology and Medicine 69007 Lyon, France.
Henning W TiemeierThe Generation R Study Group, Erasmus MC, University Medical Center Rotterdam, Rotterdam, 3000 CA the Netherlands.
George Davey SmithMRC Integrative Epidemiology Unit, School of Social and Community Medicine, University of Bristol, Bristol BS8 2BN, UK.
Dirkje PostmaDepartment of Pulmonology, University of Groningen, University Medical Center Groningen, Groningen 9700 RB, the Netherlands; GRIAC Research Institute Groningen, University of Groningen, University Medical Center Groningen, 9700 RB, the Netherlands.
Marie-France HivertObesity Prevention Program, Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, MA 02215, USA.
Brenda EskenaziCenter for Environmental Research and Children's Health (CERCH), School of Public Health, University of California Berkeley, Berkeley, CA 94720-7360, USA.
Martine VrijheidCentre for Research in Environmental Epidemiology (CREAL), Barcelona 08003, Spain; CIBER Epidemiología y Salud Pública (CIBERESP), Barcelona 08003, Spain; Universitat Pompeu Fabra (UPF), Barcelona 08003, Spain.
Hasan ArshadFaculty of Medicine, Clinical & Experimental Sciences, University of Southampton, Southampton SO16 6YD, UK.
Josep M AntóCentre for Research in Environmental Epidemiology (CREAL), Barcelona 08003, Spain; CIBER Epidemiología y Salud Pública (CIBERESP), Barcelona 08003, Spain; Universitat Pompeu Fabra (UPF), Barcelona 08003, Spain; Hospital del Mar Medical Research Institute (IMIM), Barcelona 08003, Spain.
Abbas DehghanDepartment of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam 3000 CA, the Netherlands.
Wilfried KarmausDivision of Epidemiology, Biostatistics, and Environmental Health, School of Public Health, University of Memphis, Memphis, TN 38152, USA.
Isabella Annesi-MaesanoSorbonne Universités, UPMC Univ Paris 06, INSERM, Pierre Louis Institute of Epidemiology and Public Health (IPLESP UMRS 1136), Epidemiology of Allergic and Respiratory Diseases Department (EPAR), Saint-Antoine Medical School, F75012 Paris, France.
Jordi SunyerCentre for Research in Environmental Epidemiology (CREAL), Barcelona 08003, Spain; CIBER Epidemiología y Salud Pública (CIBERESP), Barcelona 08003, Spain; Universitat Pompeu Fabra (UPF), Barcelona 08003, Spain; Hospital del Mar Medical Research Institute (IMIM), Barcelona 08003, Spain.
Akram GhantousEpigenetics Group, International Agency for Research on Cancer (IARC), 69008 Lyon, France.
Göran PershagenInstitute of Environmental Medicine, Karolinska Institutet, Stockholm 171 77, Sweden.
Nina HollandCenter for Environmental Research and Children's Health (CERCH), School of Public Health, University of California Berkeley, Berkeley, CA 94720-7360, USA.
Susan K MurphyDepartments of Obstetrics and Gynecology and Pathology, Duke University School of Medicine, Durham, NC 27710, USA.
Dawn L DeMeoChanning Division of Network Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA.
Esteban G BurchardDepartment of Medicine, University of California, San Francisco, San Francisco, CA 94143-2911, USA; Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, San Francisco, CA 94143-2911, USA.
Christine Ladd-AcostaBloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21205, USA.
Harold SniederDepartment of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen 9700 RB, the Netherlands.
Wenche NystadDivision of Mental and Physical Health, Norwegian Institute of Public Health, Oslo 0403, Norway.
Gerard H KoppelmanGRIAC Research Institute Groningen, University of Groningen, University Medical Center Groningen, 9700 RB, the Netherlands; Department of Pediatric Pulmonology and Pediatric Allergology, Beatrix Children's Hospital, University of Groningen, University Medical Center Groningen, Groningen 9700 RB, the Netherlands.
Caroline L ReltonMRC Integrative Epidemiology Unit, School of Social and Community Medicine, University of Bristol, Bristol BS8 2BN, UK.
Vincent W V JaddoeDepartment of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam 3000 CA, the Netherlands; Department of Pediatrics, Erasmus MC, University Medical Center Rotterdam, Rotterdam 3000 CA, the Netherlands; The Generation R Study Group, Erasmus MC, University Medical Center Rotterdam, Rotterdam, 3000 CA the Netherlands.
Allen WilcoxNational Institute of Environmental Health Sciences, NIH, U.S. Department of Health and Human Services, Research Triangle Park, NC 27709, USA.
Erik MelénInstitute of Environmental Medicine, Karolinska Institutet, Stockholm 171 77, Sweden; Sachs' Children's Hospital and Centre for Occupational and Environmental Medicine, Stockholm County Council, Stockholm 171 77, Sweden.
Stephanie J LondonNational Institute of Environmental Health Sciences, NIH, U.S. Department of Health and Human Services, Research Triangle Park, NC 27709, USA. Electronic address: london2@niehs.nih.gov.
Erasmus MC · NLKarolinska Institutet · SENational Institute of Environmental Health Sciences · USUniversity Medical Center Groningen · NLUniversity of Bristol · GBJohns Hopkins University · USUniversity of Groningen · NLCenter for Environmental Health · USPompeu Fabra University · ESUniversity of California, San Francisco · USCenter for Research in Environmental Epidemiology · ESCentre International de Recherche sur le Cancer · FRUniversity of Memphis · USUniversity of Southern California · USBrigham and Women's Hospital · USCentre de Recherche Épidémiologie et StatistiqueDuke University · USHarvard University · USInstitut Pierre Louis d‘Épidémiologie et de Santé Publique · FRNorwegian Institute of Public Health · NO

Funding

Translational Research Support CoreP30ES007048 · NIEHS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI ROB S MCCONNELL · 1996 to 2026
$46.4M
The Mount Sinai Transdisciplinary Center on Early Environmental ExposuresP30ES023515 · NIEHS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Chris Gennings · 2014 to 2026
$21.3M
Environmental Exposure and DNA DamageZIAES049032 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI TAYLOR, JACK A · 2009 to 2022
$13.4M
Genetic Susceptibility And The Environment In Cancer RiskZIAES049033 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI TAYLOR, JACK A · 2009 to 2022
$7.7M
Genetic And Environmental Factors In Childhood Respiratory HealthZIAES049019 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI LONDON, STEPHANIE · 2009 to 2025
$6.8M
Social Interventions to address disparities In young adult tobacco useP60MD006902 · NIMHD · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI BIBBINS-DOMINGO, KIRSTEN · 2012 to 2016
$6.4M
Molecular Mechanisms of Obesity in Children Exposed to Phthalates in UteroR01ES021369 · NIEHS · UNIVERSITY OF CALIFORNIA BERKELEY · PI HOLLAND, NINA T · 2013 to 2017
$3.1M
Nutrition, Deregulation of Imprinted GenesR01ES016772 · NIEHS · DUKE UNIVERSITY · PI HOYO, CATHRINE · 2009 to 2013
$3.1M
Obesity and deregulation of imprinted genes in early lifeR01DK085173 · NIDDK · DUKE UNIVERSITY · PI HOYO, CATHRINE, MURPHY, SUSAN KAY · 2010 to 2013
$2.3M
Prenatal Tobacco Smoke, Genetic and Epigenetic Changes, and Respiratory HealthR01ES022216 · NIEHS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI BRETON, CARRIE VAN DOREN · 2013 to 2016
$2.0M
Novel Epigenomic Biomarkers of Prenatal Risk Factors, and Childhood ObesityR01NR013945 · NINR · HARVARD SCHOOL OF PUBLIC HEALTH · PI BACCARELLI, ANDREA · 2013 to 2015
$1.6M
Prenatal Exposure to Endocrine Disrupters, DNA Methylation, and Childhood ObesityR00ES023450 · NIEHS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI JUST, ALLAN C. · 2016 to 2018
$747k
Medical Research Council G9815508Medical Research Council MC_PC_15018Medical Research Council MC_UU_12013/1Medical Research Council MC_UU_12013/2Medical Research Council MC_UU_12013/8NCBDD CDC HHS U10 DD000181NIEHS NIH HHS R01 ES016772NIEHS NIH HHS R21 ES014947Wellcome Trust 102215World Health Organization 001
6 · The paper itself

Abstract

Epigenetic modifications, including DNA methylation, represent a potential mechanism for environmental impacts on human disease. Maternal smoking in pregnancy remains an important public health problem that impacts child health in a myriad of ways and has potential lifelong consequences. The mechanisms are largely unknown, but epigenetics most likely plays a role. We formed the Pregnancy And Childhood Epigenetics (PACE) consortium and meta-analyzed, across 13 cohorts (n = 6,685), the association between maternal smoking in pregnancy and newborn blood DNA methylation at over 450,000 CpG sites (CpGs) by using the Illumina 450K BeadChip. Over 6,000 CpGs were differentially methylated in relation to maternal smoking at genome-wide statistical significance (false discovery rate, 5%), including 2,965 CpGs corresponding to 2,017 genes not previously related to smoking and methylation in either newborns or adults. Several genes are relevant to diseases that can be caused by maternal smoking (e.g., orofacial clefts and asthma) or adult smoking (e.g., certain cancers). A number of differentially methylated CpGs were associated with gene expression. We observed enrichment in pathways and processes critical to development. In older children (5 cohorts, n = 3,187), 100% of CpGs gave at least nominal levels of significance, far more than expected by chance (p value < 2.2 × 10(-16)). Results were robust to different normalization methods used across studies and cell type adjustment. In this large scale meta-analysis of methylation data, we identified numerous loci involved in response to maternal smoking in pregnancy with persistence into later childhood and provide insights into mechanisms underlying effects of this important exposure.

Indexed as

DNA MethylationEpigenesis, GeneticAsthmaChildChild, PreschoolChromosome MappingCleft LipCleft PalateFemaleGenetic Association StudiesHumansInfantInfant, NewbornPregnancySmokingWhite People

Identifiers

PMID27040690
PMCPMC4833289
OpenAlexW2330784827

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.