ArticleScientific reports2016
Dcc Mediates Functional Assembly of Peripheral Auditory Circuits.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 9 citations in OpenAlex.
- The Cxcl14 chemokine defines pioneer axon guidance and early circuit assembly in the inner ear.bioRxiv : the preprint server for biology · 2026Article
- Reviving-like prosocial behavior in response to unconscious or dead conspecifics in rodents.Science (New York, N.Y.) · 2025Article
- Molecular logic for cellular specializations that initiate the auditory parallel processing pathways.Nature communications · 2025Article
- Molecular logic for cellular specializations that initiate the auditory parallel processing pathways.bioRxiv : the preprint server for biology · 2024Article
- Wiring the senses: Factors that regulate peripheral axon pathfinding in sensory systems.Developmental dynamics : an official publication of the American Association of Anatomists · 2023Review
- ISL1 is necessary for auditory neuron development and contributes toward tonotopic organization.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- A non-autonomous function of the core PCP protein VANGL2 directs peripheral axon turning in the developing cochlea.Development (Cambridge, England) · 2018Article
- Netrin-1 Confines Rhombic Lip-Derived Neurons to the CNS.Cell reports · 2018Article
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Proper structural organization of spiral ganglion (SG) innervation is crucial for normal hearing function. However, molecular mechanisms underlying the developmental formation of this precise organization remain not well understood. Here, we report in the developing mouse cochlea that deleted in colorectal cancer (Dcc) contributes to the proper organization of spiral ganglion neurons (SGNs) within the Rosenthal's canal and of SGN projections toward both the peripheral and central auditory targets. In Dcc mutant embryos, mispositioning of SGNs occurred along the peripheral auditory pathway with misrouted afferent fibers and reduced synaptic contacts with hair cells. The central auditory pathway simultaneously exhibited similar defective phenotypes as in the periphery with abnormal exit of SGNs from the Rosenthal's canal towards central nuclei. Furthermore, the axons of SGNs ascending into the cochlear nucleus had disrupted bifurcation patterns. Thus, Dcc is necessary for establishing the proper spatial organization of SGNs and their fibers in both peripheral and central auditory pathways, through controlling axon targeting and cell migration. Our results suggest that Dcc plays an important role in the developmental formation of peripheral and central auditory circuits, and its mutation may contribute to sensorineural hearing loss.
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