Evidence map›Paper›PMID 27040492›Full record

ArticleScientific reports2016

Experimental Realisation of High-sensitivity Laboratory X-ray Grating-based Phase-contrast Computed Tomography.

Lorenz Birnbacher, Marian Willner, Astrid Velroyen, Mathias Marschner, Alexander Hipp, Jan Meiser, Frieder Koch, Tobias Schröter, Danays Kunka, Jürgen Mohr and 2 more

Abstract read
In one paragraph

Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed.

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  9. Review
  10. High-resolution multicontrast tomography with an X-ray microarray anode-structured target source.Proceedings of the National Academy of Sciences of the United States of America · 2021
    Article
  11. Dual Energy Differential Phase Contrast CT (DE-DPC-CT) Imaging.IEEE transactions on medical imaging · 2020
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Lorenz BirnbacherLehrstuhl für Biomedizinische Physik, Physik-Department &Institut für Medizintechnik, Technische Universität München, Garching, Germany.
Marian WillnerLehrstuhl für Biomedizinische Physik, Physik-Department &Institut für Medizintechnik, Technische Universität München, Garching, Germany.
Astrid VelroyenLehrstuhl für Biomedizinische Physik, Physik-Department &Institut für Medizintechnik, Technische Universität München, Garching, Germany.
Mathias MarschnerLehrstuhl für Biomedizinische Physik, Physik-Department &Institut für Medizintechnik, Technische Universität München, Garching, Germany.
Alexander HippZentrum für Material- und Küstenforschung, Helmholtz-Zentrum Geesthacht, Geesthacht, Germany.
Jan MeiserInstitut für Mikrostrukturtechnik, Karlsruher Institut für Technologie (KIT), Karlsruhe, Germany.
Frieder KochInstitut für Mikrostrukturtechnik, Karlsruher Institut für Technologie (KIT), Karlsruhe, Germany.
Tobias SchröterInstitut für Mikrostrukturtechnik, Karlsruher Institut für Technologie (KIT), Karlsruhe, Germany.
Danays KunkaInstitut für Mikrostrukturtechnik, Karlsruher Institut für Technologie (KIT), Karlsruhe, Germany.
Jürgen MohrInstitut für Mikrostrukturtechnik, Karlsruher Institut für Technologie (KIT), Karlsruhe, Germany.
Franz PfeifferLehrstuhl für Biomedizinische Physik, Physik-Department &Institut für Medizintechnik, Technische Universität München, Garching, Germany.
Julia HerzenLehrstuhl für Biomedizinische Physik, Physik-Department &Institut für Medizintechnik, Technische Universität München, Garching, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The possibility to perform high-sensitivity X-ray phase-contrast imaging with laboratory grating-based phase-contrast computed tomography (gbPC-CT) setups is of great interest for a broad range of high-resolution biomedical applications. However, achieving high sensitivity with laboratory gbPC-CT setups still poses a challenge because several factors such as the reduced flux, the polychromaticity of the spectrum, and the limited coherence of the X-ray source reduce the performance of laboratory gbPC-CT in comparison to gbPC-CT at synchrotron facilities. In this work, we present our laboratory X-ray Talbot-Lau interferometry setup operating at 40 kVp and describe how we achieve the high sensitivity yet unrivalled by any other laboratory X-ray phase-contrast technique. We provide the angular sensitivity expressed via the minimum resolvable refraction angle both in theory and experiment, and compare our data with other differential phase-contrast setups. Furthermore, we show that the good stability of our high-sensitivity setup allows for tomographic scans, by which even the electron density can be retrieved quantitatively as has been demonstrated in several preclinical studies.

Indexed as

CerebellumHumansInterferometryTomography, X-Ray Computed

Identifiers

PMID27040492
PMCPMC4819174

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.