ArticleScientific reports2016
A comprehensive strategy for the analysis of acoustic compressibility and optical deformability on single cells.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- B cell mechanobiology in health and disease: emerging techniques and insights into therapeutic responses.FEBS letters · 2025Review
- Shape-Modified Ultrathin Glass Sheet Cantilever for Precise Single Cell Stiffness Measurement.ACS measurement science au · 2025Article
- Microfluidic Technology for Measuring Mechanical Properties of Single Cells and Its Application.Bioengineering (Basel, Switzerland) · 2024Review
- Microfluidic techniques for mechanical measurements of biological samples.Biophysics reviews · 2023Review
- Label-Free Separation of Circulating Tumor Cells and Clusters by Alternating Frequency Acoustic Field in a Microfluidic Chip.International journal of molecular sciences · 2023Article
- Molecular determinants of intrinsic cellular stiffness in health and disease.Biophysical reviews · 2022Review
- Quantitative Acoustophoresis.ACS nanoscience Au · 2022Article
- Measurement of cell compressibility changes during epithelial-mesenchymal transition based on acoustofluidic microdevice.Biomicrofluidics · 2021Article
- Cellular and biomolecular detection based on suspended microchannel resonators.Biomedical engineering letters · 2021Review
- Optical manipulation: advances for biophotonics in the 21st century.Journal of biomedical optics · 2021Review
- Non-invasive acquisition of mechanical properties of cells via passive microfluidic mechanisms: A review.Biomicrofluidics · 2021Review
- Acoustic Microfluidic Separation Techniques and Bioapplications: A Review.Micromachines · 2020Review
- On-chip surface acoustic wave and micropipette aspiration techniques to assess cell elastic properties.Biomicrofluidics · 2020Article
- Characterizing the Process Physics of Ultrasound-Assisted Bioprinting.Scientific reports · 2019Article
- Noninvasive monitoring of single-cell mechanics by acoustic scattering.Nature methods · 2019Article
- On-chip cell mechanophenotyping using phase modulated surface acoustic wave.Biomicrofluidics · 2019Article
- Acoustic Compressibility of Caenorhabditis elegans.Biophysical journal · 2018Article
- Selective Adhesive Cell Capture without Molecular Specificity: New Surfaces Exploiting Nanoscopic Polycationic Features as Discrete Adhesive Units.RSC advances · 2017Article
- A Comprehensive Review of Optical Stretcher for Cell Mechanical Characterization at Single-Cell Level.Micromachines · 2016Review
Corrections and comments
- Erratum issued
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We realized an integrated microfluidic chip that allows measuring both optical deformability and acoustic compressibility on single cells, by optical stretching and acoustophoresis experiments respectively. Additionally, we propose a measurement protocol that allows evaluating the experimental apparatus parameters before performing the cell-characterization experiments, including a non-destructive method to characterize the optical force distribution inside the microchannel. The chip was used to study important cell-mechanics parameters in two human breast cancer cell lines, MCF7 and MDA-MB231. Results indicate that MDA-MB231 has both higher acoustic compressibility and higher optical deformability than MCF7, but statistical analysis shows that optical deformability and acoustic compressibility are not correlated parameters. This result suggests the possibility to use them to analyze the response of different cellular structures. We also demonstrate that it is possible to perform both measurements on a single cell, and that the order of the two experiments does not affect the retrieved values.
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