Evidence map›Paper›PMID 27040385›Full record

ArticleIranian biomedical journal2016

Activation of Toll-Like Receptors 2 by High-Mobility Group Box 1 in Monocytes from Patients with Ischemic Stroke.

Leila Sadat-Hatamnezhad, Asghar Tanomand, Javad Mahmoudi, Siamak Sandoghchian Shotorbani

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PubMed Full text at PMC Publisher
In one paragraph

Article in Iranian biomedical journal, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.7field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Neuroinflammation: friend and foe for ischemic stroke.Journal of neuroinflammation · 2019
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Leila Sadat-HatamnezhadDepartment of Dermatology, Tabriz University of Medical Sciences, Tabriz, Iran.
Asghar TanomandDepartment of Microbiology, Maraghe University of Medical Sciences, Maraghe, Iran.
Javad MahmoudiNeuroscience Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Siamak Sandoghchian ShotorbaniDepartment of Immunology, Tabriz Branch, Islamic Azad University, Tabriz, Iran.
Tabriz University of Medical Sciences · IRIslamic Azad University of Tabriz · IR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundStroke is a leading cause of death all around the world, and ischemic stroke is considered to be the most common stroke type. Toll-like receptors (TLRs) are important molecules for detection of both pathogen invasion and tissue damage. In this regard, the purpose of this study was to assess the expression level of TLR2 on monocytes in patients with ischemic stroke and to evaluate the expression change profile following high-mobility group box 1 (HMGB1) stimulation.

methodsA total of 30 patients with ischemic stroke were enrolled from November 2013 to September 2014. The real-time PCR and ELISA assays were applied to detect the concentrations of TLR2 mRNAs.

resultsTLR2 expression was found to be increased in patients with ischemic stroke, as compared to the healthy control group (P<0.001). Also, anti-TLR2 antibodies were able to decrease the expression levels of IL-17, IL-6 and IL-33. This result implies that the enhanced TLR2 pathway and Th17 cell polarization may be due to HMGB1 stimulation in ischemic stroke.

conclusionFurther clinical studies are needed for development of a new treatment strategy to inhibit the HMGB1 pathway, thus preventing the inflammation in ischemic stroke patients.

Indexed as

AgedAged, 80 and overEnzyme-Linked Immunosorbent AssayFemaleHMGB1 ProteinHumansInflammationInterleukin-17Interleukin-33Interleukin-6MaleMiddle AgedMonocytesReal-Time Polymerase Chain ReactionRNA, MessengerStrokeHMGB1 ProteinHMGB1 protein, humanIL17A protein, humanIL33 protein, humanIL6 protein, humanInterleukin-17Interleukin-33Interleukin-6RNA, MessengerTLR2 protein, humanToll-Like Receptor 2High-mobility group box 1StrokeToll-like receptor 2

Identifiers

PMID27040385
PMCPMC4983677
OpenAlexW2430239931

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.