Evidence map›Paper›PMID 27040276›Full record

ReviewSeminars in immunology2015

Dendritic cell development-History, advances, and open questions.

Sarah Puhr, Jaeyop Lee, Ekaterina Zvezdova, Yu J Zhou, Kang Liu

Abstract readReview
In one paragraph

Review in Seminars in immunology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed, 1 pooled it
0.8field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 1 synthesis or guideline pooled it, 50 citations in OpenAlex.

  1. Pooled it
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  6. Review
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  8. Fatty acid oxidation in immune function.Frontiers in immunology · 2024
    Review
  9. Article
  10. Human CD34Cellular and molecular life sciences : CMLS · 2023
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Sarah PuhrColumbia University Medical Center, Department of Microbiology and Immunology, New York, NY 10032, USA. Electronic address: sp2911@cumc.columbia.edu.
Jaeyop LeeColumbia University Medical Center, Department of Microbiology and Immunology, New York, NY 10032, USA. Electronic address: jl3567@cumc.columbia.edu.
Ekaterina ZvezdovaColumbia University Medical Center, Department of Microbiology and Immunology, New York, NY 10032, USA. Electronic address: ez2229@cumc.columbia.edu.
Yu J ZhouColumbia University Medical Center, Department of Microbiology and Immunology, New York, NY 10032, USA.
Kang LiuColumbia University Medical Center, Department of Microbiology and Immunology, New York, NY 10032, USA. Electronic address: kl2529@cumc.columbia.edu.
Columbia University Irving Medical Center · US

Funding

Understand the Role of Meningeal Dendritic Cells in CNS Anti-viral ImmunityR01AI101251 · NIAID · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI LIU, KANG · 2013 to 2017
$2.0M
Study of brain Treg localization and function during CNS infection using an enginF31NS084776 · NINDS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI PUHR, SARAH · 2013 to 2015
$115k
NIAID NIH HHS R01 AI101251NINDS NIH HHS F31 NS084776
6 · The paper itself

Abstract

Dendritic cells (DCs) are uniquely potent in orchestrating T cell immune response, thus they are indispensable immune sentinels. They originate from progenitors in the bone marrow through hematopoiesis, a highly regulated developmental process involving multiple cellular and molecular events. This review highlights studies of DC development-from the discovery of DCs as glass-adherent antigen presenting cells to the debate and resolution of their origin and lineage map. In particular, we summarize the roles of lineage-specific cytokines, the placement of distinct hematopoietic progenitors within the DC lineage and transcriptional programs governing DC development, which together have allowed us to diagram the current view of DC hematopoiesis. Important open questions and debates on the DC development and relevant models are also discussed.

Indexed as

AnimalsCell DifferentiationCell LineageDendritic CellsHematopoiesisHumansCDPCytokineDendritic cellHematopoiesisLineageMDPMononuclear phagocyte systemPre-cDCProgenitorTranscription factor

Identifiers

PMID27040276
PMCPMC5032838
OpenAlexW2312511842

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.