ArticleScientific reports2016
Comparative transcriptome analyses of seven anurans reveal functions and adaptations of amphibian skin.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed.
- Multi-Tissue Transcriptomic Analysis Reveals Tissue-Specific Thermal Responses and Sex-Biased Functional Differentiation in Reproductive Tissues of the Brown Frog (Current issues in molecular biology · 2026Article
- Integrative transcriptomics and peptidomics approach reveals unexpectedly diverse endogenous secretory peptides in Odorrana grahami frog skin.BMC biology · 2025Article
- Reorganization of bacterial community network structure in the eastern redback salamander (Plethodon cinereus) and its soil reservoir across a gradient of land use.FEMS microbiology ecology · 2025Article
- First record of microplastic contamination in adult endemic amazonian anuran species.Scientific reports · 2025Article
- Antibacterial Activity of AXOTL-13, a Novel Peptide Identified from the Transcriptome of the SalamanderPharmaceutics · 2024Article
- Immunohistochemical Characterization of Langerhans Cells in the Skin of Three Amphibian Species.Biology · 2024Article
- Framework for multi-stressor physiological response evaluation in amphibian risk assessment and conservation.Frontiers in ecology and evolution · 2024Article
- The Complex Bridge between Aquatic and Terrestrial Life: Skin Changes during Development of Amphibians.Journal of developmental biology · 2023Review
- Hepatic transcriptome of the freeze-tolerant Cope's gray treefrog, Dryophytes chrysoscelis: responses to cold acclimation and freezing.BMC genomics · 2020Article
- Skin transcriptional profiles in Oophaga poison frogs.Genetics and molecular biology · 2020Article
- Multi-Tissue Transcriptomes Yield Information on High-Altitude Adaptation and Sex-Determination inGenes · 2019Article
- Activation of the Bile Acid Pathway and No Observed Antimicrobial Peptide Sequences in the Skin of a Poison Frog.G3 (Bethesda, Md.) · 2019Article
- Multi-tissue transcriptomes of caecilian amphibians highlight incomplete knowledge of vertebrate gene families.DNA research : an international journal for rapid publication of reports on genes and genomes · 2019Article
- Article
- Frog Skin Innate Immune Defences: Sensing and Surviving Pathogens.Frontiers in immunology · 2018Review
- Improving amphibian genomic resources: a multitissue reference transcriptome of an iconic invader.GigaScience · 2018Article
- Deep sequencing analysis of toadThe journal of venomous animals and toxins including tropical diseases · 2018Article
- Transcriptome analyses of immune tissues from three Japanese frogs (genus Rana ) reveals their utility in characterizing major histocompatibility complex class II.BMC genomics · 2017Article
- High-Throughput Identification of Antimicrobial Peptides from Amphibious Mudskippers.Marine drugs · 2017Article
- Comparative transcriptome analyses reveal the genetic basis underlying the immune function of three amphibians' skin.PloS one · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Animal skin, which is the tissue that directly contacts the external surroundings, has evolved diverse functions to adapt to various environments. Amphibians represent the transitional taxon from aquatic to terrestrial life. Exploring the molecular basis of their skin function and adaptation is important to understand the survival and evolutionary mechanisms of vertebrates. However, comprehensive studies on the molecular mechanisms of skin functions in amphibians are scarce. In this study, we sequenced the skin transcriptomes of seven anurans belonging to three families and compared the similarities and differences in expressed genes and proteins. Unigenes and pathways related to basic biological processes and special functions, such as defense, immunity, and respiration, were enriched in functional annotations. A total of 108 antimicrobial peptides were identified. The highly expressed genes were similar in species of the same family but were different among families. Additionally, the positively selected orthologous groups were involved in biosynthesis, metabolism, immunity, and defense processes. This study is the first to generate extensive transcriptome data for the skin of seven anurans and provides unigenes and pathway candidates for further studies on amphibian skin function and adaptation.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.