ArticleNeuroImage2016
Power estimation for non-standardized multisite studies.
Open access · hybridAbstract readComparative StudyEvaluation StudyMulticenter Study
In one paragraph
Article in NeuroImage, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
28.9field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 43 citations in OpenAlex.
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- Image harmonization: A review of statistical and deep learning methods for removing batch effects and evaluation metrics for effective harmonization.NeuroImage · 2023Review
- Spinal Cord Atrophy Predicts Progressive Disease in Relapsing Multiple Sclerosis.Annals of neurology · 2022Observational
- Criminal arrests associated with reduced regional brain volumes in an adult population with documented childhood lead exposure.Environmental research · 2021Article
- Comparison of structural MRI brain measures between 1.5 and 3 T: Data from the Lothian Birth Cohort 1936.Human brain mapping · 2021Article
- Estimating the effect of a scanner upgrade on measures of grey matter structure for longitudinal designs.PloS one · 2021Article
- Intensity warping for multisite MRI harmonization.NeuroImage · 2020Article
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- Constructing and evaluating a cortical surface atlas and analyzing cortical sex differences in young Chinese adults.Human brain mapping · 2020Article
- Brain MRI Predicts Worsening Multiple Sclerosis Disability over 5 Years in the SUMMIT Study.Journal of neuroimaging : official journal of the American Society of Neuroimaging · 2020Article
- Standardized Brain MRI Acquisition Protocols Improve Statistical Power in Multicenter Quantitative Morphometry Studies.Journal of neuroimaging : official journal of the American Society of Neuroimaging · 2020Article
- TAPAS: A Thresholding Approach for Probability Map Automatic Segmentation in Multiple Sclerosis.NeuroImage. Clinical · 2020Article
- Accurate, rapid and reliable, fully automated MRI brainstem segmentation for application in multiple sclerosis and neurodegenerative diseases.Human brain mapping · 2019Article
- The Canadian Biomarker Integration Network in Depression (CAN-BIND): magnetic resonance imaging protocolsJournal of psychiatry & neuroscience : JPN · 2019Article
- Statistical harmonization corrects site effects in functional connectivity measurements from multi-site fMRI data.Human brain mapping · 2018Article
- SUMMIT (Serially Unified Multicenter Multiple Sclerosis Investigation): creating a repository of deeply phenotyped contemporary multiple sclerosis cohorts.Multiple sclerosis (Houndmills, Basingstoke, England) · 2018Article
- Dual-Sensitivity Multiple Sclerosis Lesion and CSF Segmentation for Multichannel 3T Brain MRI.Journal of neuroimaging : official journal of the American Society of Neuroimaging · 2018Article
- Volumetric Analysis from a Harmonized Multisite Brain MRI Study of a Single Subject with Multiple Sclerosis.AJNR. American journal of neuroradiology · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
57 authors at 14 institutions in 8 countries.
Anisha KeshavanDepartment of Neurology, University of California, San Francisco, CA, USA; UC Berkeley-UCSF Graduate Program in Bioengineering, San Francisco, CA, USA. Electronic address: anisha.keshavan@ucsf.edu.
Friedemann PaulNeuroCure Clinical Research Center and Clinical and Experimental Multiple Sclerosis Research Center, Department of Neurology, Charité University Medicine Berlin, Berlin, Germany; Experimental and Clinical Research Center, Max Delbrueck Center for Molecular Medicine and Charité University Medicine Berlin, Berlin, Germany. Electronic address: Friedemann.Paul@charite.de.
Mona K BeyerDepartment of Radiology and Nuclear Medicine, Oslo University Hospital, Oslo, Norway. Electronic address: mona.beyer@lyse.net.
Alyssa H ZhuDepartment of Neurology, University of California, San Francisco, CA, USA. Electronic address: Alyssa.Zhu@ucsf.edu.
Nico PapinuttoDepartment of Neurology, University of California, San Francisco, CA, USA. Electronic address: Nico.Papinutto@ucsf.edu.
Russell T ShinoharaDepartment of Biostatistics and Epidemiology, Center for Clinical Epidemiology and Biostatistics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, USA. Electronic address: rshi@mail.med.upenn.edu.
William SternDepartment of Neurology, University of California, San Francisco, CA, USA. Electronic address: William.Stern@ucsf.edu.
Michael AmannDepartment of Neurology, Basel University Hospital, University of Basel, Basel, Switzerland. Electronic address: michael.amann@usb.ch.
Rohit BakshiBrigham and Women's Hospital, MA, United States. Electronic address: rbakshi@post.harvard.edu.
Antje BischofDepartment of Neurology, University of California, San Francisco, CA, USA; Department of Neurology, Basel University Hospital, University of Basel, Basel, Switzerland; Clinical Immunology, University Hospital Basel,University of Basel, Basel, Switzerland. Electronic address: antje.Bischof@ucsf.edu.
Alessandro CarrieroDepartment of Translational Medicine, Department of Radiology, UPO University, Via Solaroli 17, 28100 Novara, Italy. Electronic address: alessandro.carriero@med.unipmn.it.
Manuel ComabellaHospital Universitari Vall d'Hebron, Barcelona, Spain. Electronic address: manuel.comabella@vhir.org.
Jason C CraneDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, CA, USA. Electronic address: Jason.Crane@ucsf.edu.
Sandra D'AlfonsoDepartment of Health Sciences, UPO University, Novara, Italy. Electronic address: sandra.dalfonso@med.uniupo.it.
Philippe DemaerelDepartment of Radiology, University Hospitals Leuven, Leuven, Belgium. Electronic address: Philippe.Demaerel@uzleuven.be.
Benedicte DuboisKU Leuven-University of Leuven, Department of Neurosciences, Leuven, Belgium. Electronic address: Benedicte.dubois@uzleuven.be.
Massimo FilippiNeuroimaging Research Unit, Institute of Experimental Neurology, Division of Neuroscience, San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Milan, Italy. Electronic address: zonca.lucia@hsr.it.
Vinzenz FleischerDepartment of Neurology, Focus Program Translational Neuroscience (FTN) and Immunotherapy (FZI), Rhine-Main Neuroscience Network (rmn2), University Medical Centre of the Johannes Gutenberg University Mainz, Germany. Electronic address: Vinzenz.Fleischer@unimedizin-mainz.de.
Bertrand FontaineHôpital Pitié-Salpêtrière, ICM, UPMC 06 UM 75, INSERM U 1127, CNRS UMR 7225, IHU-A-ICM, AP-HP: Pôle des maladies du système nerveux, 47 boulevard de l'Hôpital, 75013 Paris, France. Electronic address: bertrand.fontaine@upmc.fr.
Laura GaetanoDepartment of Neurology, Basel University Hospital, University of Basel, Basel, Switzerland; Medical Image Analysis Center (MIAC AG), Basel, Switzerland. Electronic address: laura.gaetanosf@gmail.com.
An GorisKU Leuven-University of Leuven, Department of Neurosciences, Leuven, Belgium. Electronic address: An.Goris@med.kuleuven.be.
Christiane GraetzDepartment of Neurology, Focus Program Translational Neuroscience (FTN) and Immunotherapy (FZI), Rhine-Main Neuroscience Network (rmn2), University Medical Centre of the Johannes Gutenberg University Mainz, Germany. Electronic address: Christiane.Graetz@unimedizin-mainz.de.
Adriane GrögerDepartment of Neurology, Focus Program Translational Neuroscience (FTN) and Immunotherapy (FZI), Rhine-Main Neuroscience Network (rmn2), University Medical Centre of the Johannes Gutenberg University Mainz, Germany. Electronic address: adriane.groeger@unimedizin-mainz.de.
Sergiu GroppaDepartment of Neurology, Focus Program Translational Neuroscience (FTN) and Immunotherapy (FZI), Rhine-Main Neuroscience Network (rmn2), University Medical Centre of the Johannes Gutenberg University Mainz, Germany. Electronic address: Sergiu.Groppa@unimedizin-mainz.de.
David A HaflerDepartments of Neurology and Immunobiology, Yale School of Medicine, CT, USA. Electronic address: david.hafler@yale.edu.
Hanne F HarboDepartment of Neurology, Oslo University Hospital and University of Oslo, Oslo, Norway. Electronic address: h.f.harbo@medisin.uio.no.
Bernhard HemmerDept. Neurology of the Klinikum rechts der Isar, Technische Universität München, Munich, Germany; Munich Cluster of Systems Neurology (SyNery), Germany. Electronic address: hemmer@tum.de.
Kesshi JordanDepartment of Neurology, University of California, San Francisco, CA, USA; UC Berkeley-UCSF Graduate Program in Bioengineering, San Francisco, CA, USA. Electronic address: Kesshi.Jordan@ucsf.edu.
Ludwig KapposDepartment of Neurology, Basel University Hospital, University of Basel, Basel, Switzerland. Electronic address: Ludwig.Kappos@usb.ch.
Gina KirkishDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, CA, USA. Electronic address: Gina.Kirkish@ucsf.edu.
Sara LlufriuCenter for Neuroimmunology, Hospital Clinic Barcelona, IDIBAPS, Barcelona, Spain. Electronic address: SLLUFRIU@clinic.ub.es.
Stefano MagonDepartment of Neurology, Basel University Hospital, University of Basel, Basel, Switzerland. Electronic address: Stefano.Magon@usb.ch.
Filippo Martinelli-BoneschiNeuroimaging Research Unit, Institute of Experimental Neurology, Division of Neuroscience, San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Milan, Italy. Electronic address: martinelli.filippo@hsr.it.
Jacob L McCauleyJohn P. Hussman Institute for Human Genomics and the Dr. John T. Macdonald Foundation Department of Human Genetics, University of Miami, Miami, USA. Electronic address: jmccauley@med.miami.edu.
Xavier MontalbanHospital Universitari Vall d'Hebron, Barcelona, Spain. Electronic address: xavier.montalban@cem-cat.org.
Mark MühlauDept. Neurology of the Klinikum rechts der Isar, Technische Universität München, Munich, Germany; TUM-Neuroimaging Center, Technische Universität München, Munich, Germany. Electronic address: muehlau@lrz.tu-muenchen.de.
Daniel PelletierDepartments of Neurology and Immunobiology, Yale School of Medicine, CT, USA. Electronic address: daniel.pelletier@yale.edu.
Pradip M PattanyDepartment of Radiology, University of Miami Miller School of Medicine, Miami, FL, USA. Electronic address: PPattany@med.miami.edu.
Margaret Pericak-VanceJohn P. Hussman Institute for Human Genomics and the Dr. John T. Macdonald Foundation Department of Human Genetics, University of Miami, Miami, USA. Electronic address: MPericak@med.miami.edu.
Isabelle Cournu-RebeixHôpital Pitié-Salpêtrière, ICM, UPMC 06 UM 75, INSERM U 1127, CNRS UMR 7225, IHU-A-ICM, AP-HP: Pôle des maladies du système nerveux, 47 boulevard de l'Hôpital, 75013 Paris, France. Electronic address: isabelle.rebeix@upmc.fr.
Maria A RoccaNeuroimaging Research Unit, Institute of Experimental Neurology, Division of Neuroscience, San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Milan, Italy. Electronic address: rocca.mara@hsr.it.
Alex RoviraHospital Universitari Vall d'Hebron, Barcelona, Spain. Electronic address: alex.rovira@idi.gencat.cat.
Regina SchlaegerDepartment of Neurology, University of California, San Francisco, CA, USA; Department of Neurology, Basel University Hospital, University of Basel, Basel, Switzerland; Clinical Immunology, University Hospital Basel,University of Basel, Basel, Switzerland. Electronic address: regina.schlaeger@ucsf.edu.
Albert SaizCenter for Neuroimmunology, Hospital Clinic Barcelona, IDIBAPS, Barcelona, Spain. Electronic address: ASAIZ@clinic.ub.es.
Till SprengerDepartment of Neurology, Basel University Hospital, University of Basel, Basel, Switzerland; DKD Helios Klinik Wiesbaden, Wiesbaden, Germany. Electronic address: Till.sprenger@usb.ch.
Alessandro SteccoSection of Neuroradiology, Department of Radiology, Maggiore Hospital, Corso Mazzini 18, 28100, Novara, Italy. Electronic address: a.stecco@libero.it.
Bernard M J UitdehaagMS Center Amsterdam, VU University Medical Center Amsterdam, The Netherlands. Electronic address: bmj.uitdehaag@vumc.nl.
Pablo VillosladaCenter for Neuroimmunology, Hospital Clinic Barcelona, IDIBAPS, Barcelona, Spain. Electronic address: Pablo.VillosladaDiaz@ucsf.edu.
Mike P WattjesMS Center Amsterdam, VU University Medical Center Amsterdam, The Netherlands. Electronic address: m.wattjes@vumc.nl.
Howard WeinerBrigham and Women's Hospital, MA, United States. Electronic address: hweiner@rics.bwh.harvard.edu.
Jens WuerfelNeuroCure Clinical Research Center and Clinical and Experimental Multiple Sclerosis Research Center, Department of Neurology, Charité University Medicine Berlin, Berlin, Germany; Medical Image Analysis Center, Basel, Switzerland. Electronic address: jw@miac.ch.
Claus ZimmerDept. Neuroradiology, Klinikum rechts der Isar, Technische Universität München, Munich, Germany. Electronic address: claus.zimmer@tum.de.
Frauke ZippDepartment of Neurology, Focus Program Translational Neuroscience (FTN) and Immunotherapy (FZI), Rhine-Main Neuroscience Network (rmn2), University Medical Centre of the Johannes Gutenberg University Mainz, Germany. Electronic address: Frauke.zipp@unimedizin-mainz.de.
International Multiple Sclerosis Genetics Consortium. Electronic address: AIVINSON@PARTNERS.ORGInternational Multiple Sclerosis Genetics Consortium, USA, EU, AU.
Stephen L HauserDepartment of Neurology, University of California, San Francisco, CA, USA. Electronic address: Stephen.Hauser@ucsf.edu.
Jorge R OksenbergDepartment of Neurology, University of California, San Francisco, CA, USA. Electronic address: Jorge.Oksenberg@ucsf.edu.
Roland G HenryDepartment of Neurology, University of California, San Francisco, CA, USA; UC Berkeley-UCSF Graduate Program in Bioengineering, San Francisco, CA, USA; Department of Radiology and Biomedical Imaging, University of California, San Francisco, CA, USA. Electronic address: Roland.Henry@ucsf.edu.
Hebron University · PSBrigham and Women's Hospital · USInstitut du Cerveau · FRInstitute of Neuroimmunology of the Slovak Academy of Sciences · SKSan Raffaele University of Rome · ITAmsterdam UMC Location VUmc · NLDepartment of Medical Sciences · BYHelios Kliniken · DEJohannes Gutenberg University Mainz · DEKlinikum rechts der Isar · DEMax Delbrück Center · DENational Clinical Research · USTechnical University of Munich · DEUniversity Hospital and Clinics · US
Funding
A Haplotype Map for Multiple SclerosisR01NS049477 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI HAUSER, STEPHEN L · 2005 to 2014
$15.3MNINDS Research Education Programs for Residents and Fellows in Neurology, Neurosurgery, Neuropathology, Neuroradiology and Emergency Medicine (R25)R25NS070680 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI JOSEPHSON, SCOTT ANDREW · 2010 to 2023
$6.8MNINDS NIH HHS R01 NS049477NINDS NIH HHS R25 NS070680
Abstract
A concern for researchers planning multisite studies is that scanner and T1-weighted sequence-related biases on regional volumes could overshadow true effects, especially for studies with a heterogeneous set of scanners and sequences. Current approaches attempt to harmonize data by standardizing hardware, pulse sequences, and protocols, or by calibrating across sites using phantom-based corrections to ensure the same raw image intensities. We propose to avoid harmonization and phantom-based correction entirely. We hypothesized that the bias of estimated regional volumes is scaled between sites due to the contrast and gradient distortion differences between scanners and sequences. Given this assumption, we provide a new statistical framework and derive a power equation to define inclusion criteria for a set of sites based on the variability of their scaling factors. We estimated the scaling factors of 20 scanners with heterogeneous hardware and sequence parameters by scanning a single set of 12 subjects at sites across the United States and Europe. Regional volumes and their scaling factors were estimated for each site using Freesurfer's segmentation algorithm and ordinary least squares, respectively. The scaling factors were validated by comparing the theoretical and simulated power curves, performing a leave-one-out calibration of regional volumes, and evaluating the absolute agreement of all regional volumes between sites before and after calibration. Using our derived power equation, we were able to define the conditions under which harmonization is not necessary to achieve 80% power. This approach can inform choice of processing pipelines and outcome metrics for multisite studies based on scaling factor variability across sites, enabling collaboration between clinical and research institutions.
Indexed as
ArtifactsModels, StatisticalAlgorithmsBrainComputer SimulationEquipment DesignEquipment Failure AnalysisEuropeHumansImage EnhancementImage Interpretation, Computer-AssistedMagnetic Resonance ImagingReproducibility of ResultsSensitivity and SpecificityUnited States
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