ArticleJournal of neurology2016
Women have a poorer very long-term functional outcome after stroke among adults aged 18-50 years: the FUTURE study.
Article in Journal of neurology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Pooled it
- Trial
- United Kingdom Young Stroke Study (UKYSS): study protocol for an ambispective observational study.BMJ neurology open · 2026Article
- 2025 Heart Disease and Stroke Statistics: A Report of US and Global Data From the American Heart Association.Circulation · 2025Review
- Nonadherence to Preventive Medications After Ischemic Stroke: Opportunities to Target Interventions by Sex, Race, and Ethnicity.Journal of the American Heart Association · 2024Article
- Sex differences in clinical risk factors in obese ischemic stroke patients with a history of smoking.BMC cardiovascular disorders · 2024Article
- Sex Differences in Severity and Risk Factors for Ischemic Stroke in Patients With Hyperlipidemia.Neuroscience insights · 2024Article
- MRI Radiomics and Predictive Models in Assessing Ischemic Stroke Outcome-A Systematic Review.Diagnostics (Basel, Switzerland) · 2023Review
- Heart Disease and Stroke Statistics-2023 Update: A Report From the American Heart Association.Circulation · 2023Review
- Heart Disease and Stroke Statistics-2021 Update: A Report From the American Heart Association.Circulation · 2021Article
- Article
- Maternal Race/Ethnicity, Hypertension, and Risk for Stroke During Delivery Admission.Journal of the American Heart Association · 2020Observational
- Return to work after stroke: A Swedish nationwide registry-based study.Acta neurologica Scandinavica · 2020Article
- Aspirin reduces long-term stroke risk in women with prior hypertensive disorders of pregnancy.Neurology · 2019Article
- Low self-reported sports activity before stroke predicts poor one-year-functional outcome after first-ever ischemic stroke in a population-based stroke register.BMC neurology · 2018Article
- Association of Childhood Body Mass Index and Change in Body Mass Index With First Adult Ischemic Stroke.JAMA neurology · 2017Article
- Confounding by Pre-Morbid Functional Status in Studies of Apparent Sex Differences in Severity and Outcome of Stroke.Stroke · 2017Article
- Stroke in women - from evidence to inequalities.Nature reviews. Neurology · 2017Review
- Heart Disease and Stroke Statistics-2017 Update: A Report From the American Heart Association.Circulation · 2017Review
- Sex differences in comorbidities associated with exclusion from thrombolytic therapy in ischemic stroke patients with heart failure: A retrospective data analysis.JRSM cardiovascular diseaseArticle
Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Due to their young age young stroke survivors have to cope with a dramatic impact on their life for the decades to come. We investigated the sex-specific very long-term functional outcome after transient ischemic attack (TIA) and ischemic stroke (IS) in adults aged 18-50 years. This study is part of a cohort study among 619 first-ever young ischemic stroke patients, admitted to our department between January 1, 1980 and November 1, 2010. Functional outcome was assessed during follow-up in 2009-2011 and in 2014-2015 with the modified Rankin Scale (mRS) and instrumental Activities of Daily Living scale (iADL). Risk factors for a poor functional outcome (mRS > 2 and iADL < 8) were calculated by logistic regression analysis. After a mean follow-up of 13.9 (SD 8.2) years, 24.5 % of TIA patients and 44.7 % of IS patients had a poor functional outcome (mRS > 2). When assessing the survivors, 15.2 % of TIA patients and 22.9 % of IS patients had a poor outcome as assessed by iADL. The strongest baseline predictors of poor outcome were female sex (OR 2.7, 95 % CI 1.5-5.0) and baseline NIHSS (OR 1.1, 95 % CI 1.1-1.2 per point increase). In conclusion, 14 years after an ischemic cerebrovascular event in young adults, one out of five IS survivors and one out of ten TIA survivors is still dependent in daily life, with a two to threefold higher risk of a poor outcome in women. This includes a period of life, during which important decisions regarding work and family life have to be made.
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