ArticleBrain, behavior, and immunity2016
Mind-body interactions in the regulation of airway inflammation in asthma: A PET study of acute and chronic stress.
Article in Brain, behavior, and immunity, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 43 papers, 3 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
43 citing papers in PubMed, 3 syntheses or guidelines pooled it, 71 citations in OpenAlex.
- The historical progression of positron emission tomography research in neuroendocrinology.Frontiers in neuroendocrinology · 2023Pooled it
- Individual differences in glucocorticoid regulation: Does it relate to disease risk and resilience?Frontiers in neuroendocrinology · 2020Pooled it
- Functional neuroanatomy of peripheral inflammatory physiology: A meta-analysis of human neuroimaging studies.Neuroscience and biobehavioral reviews · 2018Pooled it
- Neural mechanisms of mindfulness-based stress reduction in asthma.Scientific reports · 2026Trial
- Resting state functional connectivity changes following mindfulness-based stress reduction predict improvements in disease control for patients with asthma.Brain, behavior, and immunity · 2024Trial
- Longitudinal co-variations between inflammatory cytokines, lung function and patient reported outcomes in patients with asthma.PloS one · 2017Trial
- Associations of sedentary behavior and physical activity with sleep disorders in patients with osteoarthritis: The mediating role of inflammatory biomarkers.Osteoarthritis and cartilage open · 2026Article
- Asthma: Biomedical and Psychobiological Perspectives.Biopsychosocial science and medicine · 2025Review
- Fueling the fire in the lung-brain axis: The salience network connects allergen-provoked TH17 responses to psychological stress in asthma.Brain, behavior, and immunity · 2025Article
- Airway sensory systems: breathing new life into microbiota-brain communication.Frontiers in cellular neuroscience · 2025Review
- Pulmonary Rehabilitation Reduces Airway Inflammation in Asthma Patients with High FeJournal of asthma and allergy · 2025Article
- Real-time motion-enabling positron emission tomography of the brain of upright ambulatory humans.Communications medicine · 2024Article
- Systemic Inflammation in Asthma: What Are the Risks and Impacts Outside the Airway?The journal of allergy and clinical immunology. In practice · 2024Review
- Molecular pathways underlying lung-brain axis signaling in asthma: Relevance for psychopathology and neuroinflammation.The Journal of allergy and clinical immunology · 2024Article
- Amygdalar involvement in respiratory dysfunction.Frontiers in physiology · 2024Review
- Research on the Mechanism and Application of Acupuncture Therapy for Asthma: A Review.Journal of asthma and allergy · 2024Review
- Ozone Pollution, Perceived Support at Home, and Asthma Symptom Severity in the Adolescent Sample of the California Health Interview Survey.International journal of behavioral medicine · 2023Article
- Depressive symptoms are related to asthma control but not self-management among rural adolescents.Frontiers in allergy · 2023Article
- Investigation of altered spontaneous brain activity in patients with bronchial asthma using the percent amplitude of fluctuation method: a resting-state functional MRI study.Frontiers in human neuroscience · 2023Article
- Brain-Airway Interactions in Asthma.Advances in experimental medicine and biology · 2023Article
Corrections and comments
- Erratum issued
Authors and funding
12 authors at 1 institution in 1 country.
Funding
Abstract
backgroundPsychological stress has long been recognized as a contributing factor to asthma symptom expression and disease progression. Yet, the neural mechanisms that underlie this relationship have been largely unexplored in research addressing the pathophysiology and management of asthma. Studies that have examined the mechanisms of this relationship in the periphery suggest that it is the superimposition of acute stress on top of chronic stress that is of greatest concern for airway inflammation.
methodsWe compared asthmatic individuals with high and low levels of chronic life stress in their neural and peripheral physiological responses to the Trier Social Stress Test and a matched control task. We used FDG-PET to measure neural activity during performance of the two tasks. We used both circulating and airway-specific markers of asthma-related inflammation to assess the impact of acute stress in these two groups.
resultsAsthmatics under chronic stress had a larger HPA-axis response to an acute stressor, which failed to show the suppressive effects on inflammatory markers observed in those with low chronic stress. Moreover, our PET data suggest that greater activity in the anterior insula during acute stress may reflect regulation of the effect of stress on inflammation. In contrast, greater activity in the mid-insula and perigenual anterior cingulate seems to reflect greater reactivity and was associated with greater airway inflammation, a more robust alpha amylase response, and a greater stress-induced increase in proinflammatory cytokine mRNA expression in airway cells.
conclusionsAcute stress is associated with increases in markers of airway inflammation in asthmatics under chronic stress. This relationship may be mediated by interactions between the insula and anterior cingulate cortex, that determine the salience of environmental cues, as well as descending regulatory influence of inflammatory pathways in the periphery.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.