Evidence map›Paper›PMID 27039205›Full record

Trial reportSupportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer2016

"Enjoy glass of wine before eating:" a randomized trial to test the orexigenic effects of this advice in advanced cancer patients.

Aminah Jatoi, Rui Qin, Daniel Satele, Shaker Dakhil, Pankaj Kumar, David B Johnson, Sachdev P Thomas, Philip J Stella, Jose Castillo, Min Li and 1 more

Abstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 4 pooled it
1.0field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 4 syntheses or guidelines pooled it, 11 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. A systematic review examining nutrition support interventions in patients with incurable cancer.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2020
    Pooled it
  5. Review
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 7 institutions in 1 country.

Aminah JatoiDepartment of Oncology, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA. jatoi.aminah@mayo.edu.
Rui QinDivision of Biomedical Statistics, Mayo Clinic, Rochester, MN, USA.
Daniel SateleDivision of Biomedical Statistics, Mayo Clinic, Rochester, MN, USA.
Shaker DakhilCancer Center of Kansas, Wichita, KS, USA.
Pankaj KumarIllinois Cancer Care - Peoria, Peoria, IL, USA.
David B JohnsonCancer Center of Kansas, Wichita, KS, USA.
Sachdev P ThomasIllinois Cancer Care - Peoria, Peoria, IL, USA.
Philip J StellaSaint Joseph Mercy Hospital, Ann Arbor, MI, USA.
Jose CastilloGeisinger Wyoming Valley, Wilkes-Barre, PA, USA.
Min LiUniversity of Oklahoma, Oklahoma City, OK, USA.
Martin Fernandez-ZapicoSchulze Center for Novel Therapeutics, Mayo Clinic, Rochester, MN, USA.
Mayo Clinic · USCancer Center of Kansas · USIllinois CancerCare · USGeisinger Wyoming Valley Medical Center · USNovel (United States) · USOklahoma City University · USTrinity Health Ann Arbor Hospital · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundBecause the extant literature suggests wine increases appetite, this study sought to determine whether this effect could be observed in advanced cancer patients with appetite loss.

methodsAdvanced cancer patients with self-reported loss of appetite were randomly assigned to white wine with ≤15 % alcohol content twice a day for 3-4 weeks versus a nutritional supplement, such as Boost® or Ensure®. Patients assigned to wine were encouraged to also take a nutritional supplement, whereas patients assigned to the nutritional supplement arm were told to abstain completely from alcohol. Patient-reported outcomes were captured with a validated questionnaire to assess the primary endpoint of appetite improvement.

resultsA total of 141 patients (118 evaluable) were enrolled. Twenty-eight patients (48 %) in the wine arm reported an improvement in appetite at some point during the treatment period, whereas 22 patients (37 %) assigned to the nutritional supplement arm also reported improvement (p = 0.35). Other appetite-related questions and questionnaire items showed no statistically significant differences between treatment arms. In both arms, approximately 9 % of patients achieved weight stability (p = 0.98); median survival was not statistically different. Both interventions were well tolerated.

conclusionAs prescribed in this trial, wine does not improve appetite or weight in advanced cancer patients.

Indexed as

WineAdultAgedAged, 80 and overAnorexiaAppetiteBody WeightEatingFemaleHumansMaleMiddle AgedNeoplasmsQuality of LifeSurveys and QuestionnairesAnorexiaAppetiteCancerHungerWeight loss

Identifiers

PMID27039205
OpenAlexW2322300985

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.