ArticleAging cell2016
A chromatin modifier integrates insulin/IGF-1 signalling and dietary restriction to regulate longevity.
Article in Aging cell, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Remembrance of things past: Towards a life-course biology of aging.PLoS biology · 2026Article
- mRNA Isoforms and Variants in Health and Disease.International journal of molecular sciences · 2025Review
- Molecular Adjustment to a Social Niche: Brain Transcriptomes Reveal Divergent Influence of Social Environment on the Two Queen Morphs of the Ant Temnothorax rugatulus.Molecular ecology · 2025Article
- Weight of time: exploring the link between obesity and aging.Aging clinical and experimental research · 2025Review
- Chromatin and epigenetics in aging biology.Genetics · 2025Review
- ZFP1 is a biomarker related to poor prognosis and immunity in gastric cancer.Scientific reports · 2024Article
- The chromatin factors SET-26 and HCF-1 oppose the histone deacetylase HDA-1 in longevity and gene regulation in C. elegans.Nature communications · 2024Article
- The conserved microRNA-229 family controls low-insulin signaling and dietary restriction induced longevity through interactions with SKN-1/NRF2.Aging cell · 2023Article
- Dietary restriction improves proteostasis and increases life span through endoplasmic reticulum hormesis.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Nuclear Organization in Stress and Aging.Cells · 2019Review
- Article
- Emerging topics in C. elegans aging research: Transcriptional regulation, stress response and epigenetics.Mechanisms of ageing and development · 2019Review
- Regulation of Age-related Decline by Transcription Factors and Their Crosstalk with the Epigenome.Current genomics · 2018Review
- Dietary restriction and lifespan: Lessons from invertebrate models.Ageing research reviews · 2017Review
- Article
- Differential alternative splicing coupled to nonsense-mediated decay of mRNA ensures dietary restriction-induced longevity.Nature communications · 2017Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Insulin/IGF-1-like signalling (IIS) and dietary restriction (DR) are the two major modulatory pathways controlling longevity across species. Here, we show that both pathways license a common chromatin modifier, ZFP-1/AF10. The downstream transcription factors of the IIS and select DR pathways, DAF-16/FOXO or PHA-4/FOXA, respectively, both transcriptionally regulate the expression of zfp-1. ZFP-1, in turn, negatively regulates the expression of DAF-16/FOXO and PHA-4/FOXA target genes, apparently forming feed-forward loops that control the amplitude as well as the duration of gene expression. We show that ZFP-1 mediates this regulation by negatively influencing the recruitment of DAF-16/FOXO and PHA-4/FOXA to their target promoters. Consequently, zfp-1 is required for the enhanced longevity observed during DR and on knockdown of IIS. Our data reveal how two distinct sensor pathways control an overlapping set of genes, using different downstream transcription factors, integrating potentially diverse and temporally distinct nutritional situations.
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Registered trials
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