ArticleOsteoarthritis and cartilage2016
Synovial volume vs synovial measurements from dynamic contrast enhanced MRI as measures of response in osteoarthritis.
Article in Osteoarthritis and cartilage, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 44 citations in OpenAlex.
- With a biomechanical treatment in knee osteoarthritis, less knee pain did not correlate with synovitis reduction.BMC musculoskeletal disorders · 2017Trial
- Dynamic contrast-enhanced magnetic resonance imaging of the synovium and synovial subregions in knee osteoarthritis: test-retest repeatability.Quantitative imaging in medicine and surgery · 2026Article
- Use of DCE-MRI in arthritis in the appendicular skeleton: a narrative review.Skeletal radiology · 2025Review
- Multifaceted imaging strategies for clinical trials of knee osteoarthritis-a tightly interlinked value and precision chain.Skeletal radiology · 2025Review
- Direct shoulder MR arthrography using an iron-based positive T1 contrast agent (NEMO-103): comparison of image quality with gadolinium-based contrast.Scientific reports · 2025Article
- The inflammatory endotype in osteoarthritis: Reflections from the 2024 OARSI clinical trials symposium (CTS) with a special emphasis on feasibility for clinical development.Osteoarthritis and cartilage open · 2025Review
- Imaging-based measures of synovitis in knee osteoarthritis: A scoping review and narrative synthesis.Osteoarthritis and cartilage open · 2025Review
- Genicular Arteries Embolization for Patients with Osteoarthritis, Their Selection, and Follow-Up Based on MRI Findings.Medicina (Kaunas, Lithuania) · 2025Review
- Transformative approaches for effective clinical trials to reduce the disease burden of osteoarthritis.Seminars in arthritis and rheumatism · 2025Review
- Advanced Magnetic Resonance Imaging and Molecular Imaging of the Painful Knee.Seminars in musculoskeletal radiology · 2023Review
- Structural phenotypes of knee osteoarthritis: potential clinical and research relevance.Skeletal radiology · 2023Review
- Inflammation-Driven Secretion Potential Is Upregulated in Osteoarthritic Fibroblast-Like Synoviocytes.International journal of molecular sciences · 2022Article
- Imaging of Synovial Inflammation in Osteoarthritis, From theAJR. American journal of roentgenology · 2022Review
- Article
- Gadolinium-free assessment of synovitis using diffusion tensor imaging.NMR in biomedicine · 2022Article
- Perfusion in bone marrow lesions assessed on DCE-MRI and its association with pain in knee osteoarthritis: a cross-sectional study.Skeletal radiology · 2020Article
- Efficacy and predictive factors of response to intra-articular corticosteroids in knee osteoarthritis.Reumatologia · 2020Review
- MRI of synovitis and joint fluid.Journal of magnetic resonance imaging : JMRI · 2019Review
- Measurement of synovial tissue volume in knee osteoarthritis using a semiautomated MRI-based quantitative approach.Magnetic resonance in medicine · 2019Article
- Deep convolutional neural network for segmentation of knee joint anatomy.Magnetic resonance in medicine · 2018Article
Corrections and comments
- Erratum issued
Authors and funding
9 authors at 4 institutions in 2 countries.
Funding
Abstract
objectiveSynovium is increasingly a target of osteoarthritis (OA) treatment, yet its optimal measurement is unclear. Using dynamic contrast enhanced (DCE) MRI in knee OA patients before and after intraarticular steroid injection, we compared the responsiveness of static synovial volume measures to measures of dynamic changes in synovial enhancement, changes that are strongly related to synovial vascularity.
methodsNinety three patients underwent DCE-MRI before and 1-2 weeks after intra-articular injection of 80 mg methylprednisolone. Synovium was segmented and volume, relative enhancement rate (RER), maximum relative enhancement (REmax), late relative enhancement (RElate) and pharmacokinetic parameters (K(trans), ve) were calculated. KOOS (knee injury and osteoarthritis outcome score) pain score was recorded before and after injection. Standardized change scores were calculated for each parameter. Linear regression and Pearson's correlations were used to investigate the relationship between change in MRI parameters and change in pain.
resultsThe change in standardized score for the measures of synovial enhancement, RElate and REmax were -0.58 (95% CI -0.79 to -0.37) and -0.62 (95% CI -0.83 to -0.41) respectively, whereas the score for synovial volume was -0.30 (-0.52 to -0.09). Further, change in knee pain correlated more strongly with changes in enhancement (for both REmax and RElate, r = -0.27 (95% CI -0.45 to -0.07)) than with changes in synovial volume -0.15 (-0.35 to 0.05).
conclusionThis study suggests DCE-MRI derived measures of synovial enhancement may be more sensitive to the response to treatment and more strongly associated with changes in pain than synovial volume and may be better outcomes for assessment of structural effects of treatment in OA.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.