ArticleEcotoxicology (London, England)2016
Cadmium induced oxidative damage and apoptosis in the hepatopancreas of Meretrix meretrix.
Article in Ecotoxicology (London, England), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 67 citations in OpenAlex.
- Influence of Ultrafine Bubbles (UFBs) on Cadmium Toxicity in Polypedilum nubifer (Chironomidae).Environmental analysis, health and toxicology · 2026Article
- Effect of Acute Cadmium Exposure and Short-Term Depuration on Oxidative Stress and Immune Responses inToxics · 2025Article
- Toxic Effects of Acute Water Selenium Exposure onAnimals : an open access journal from MDPI · 2025Article
- Expression and Functional Analysis of the Metallothionein and Metal-Responsive Transcription Factor 1 inInternational journal of molecular sciences · 2024Article
- Cadmium Highlights Common and Specific Responses of Two Freshwater Sentinel Species,Proteomes · 2024Article
- Transcriptome Analysis and Identification of Cadmium-Induced Oxidative Stress Response Genes in DifferentAnimals : an open access journal from MDPI · 2024Article
- Biochemical, Genotoxic and Histological Implications of Polypropylene Microplastics on Freshwater FishToxics · 2023Article
- Characterization of Copper/Zinc Superoxide Dismutase Activity onInternational journal of molecular sciences · 2022Article
- Curative Potential of Substances with Bioactive Properties to Alleviate Cd Toxicity: A Review.International journal of environmental research and public health · 2022Review
- Mechanism of Cadmium Exposure Induced Hepatotoxicity in the Mud Crab (Antioxidants (Basel, Switzerland) · 2022Article
- Cadmium-induced ultrastructural changes and apoptosis in the gill of freshwater mussel Anodonta woodiana.Environmental science and pollution research international · 2022Article
- Cloning, Functional Characterization and Response to Cadmium Stress of the Thioredoxin-like Protein 1 Gene fromInternational journal of molecular sciences · 2021Article
- Cadmium-induced oxidative stress in Meretrix meretrix gills leads to mitochondria-mediated apoptosis.Ecotoxicology (London, England) · 2021Article
- Enhanced Cadmium Accumulation and Tolerance in Transgenic Hairy Roots ofLife (Basel, Switzerland) · 2020Article
- Hepatoprotective Effect of Oleuropein-Rich Extract from Olive Leaves against Cadmium-Induced Toxicity in Mice.BioMed research international · 2020Article
- Comparative Transcriptome Analysis of the Molecular Mechanism of the Hairy Roots ofInternational journal of molecular sciences · 2019Article
- Article
- PARP-1 overexpression contributes to Cadmium-induced death in rat proximal tubular cells via parthanatos and the MAPK signalling pathway.Scientific reports · 2017Article
- Treatment of cadmium-induced renal oxidative damage in rats by administration of alpha-lipoic acid.Environmental science and pollution research international · 2017Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Even trace amounts of cadmium (Cd), a non-essential metal, are known to be toxic to aquatic organisms. Here we investigated the relationship between cadmium ion (Cd(2+)) exposure and oxidative damage and apoptosis in the hepatopancreas of the clam Meretrix meretrix. Clams were exposed to different concentrations of Cd(2+) (0, 1.5, 3, 6 and 12 mg L(-1)) for 5 days. We monitored both antioxidant enzyme activity, including that of superoxide dismutase (SOD), catalase (CAT), glutathione peroxidases (GPx), and levels of malondialdehyde (MDA), glutathione (GSH) and glutathione disulfide (GSSG). Apoptosis of hepatopancreatic cells was detected by DNA laddering and AO/EB double fluorescent staining. The results show that the rate of apoptotis, MDA levels, and caspase-3 activity, increased with Cd(2+) concentration, whereas GPx activity and the ratio of GSH/GSSG, decreased. SOD and CAT enzyme activity first increased, then decreased, with increasing Cd(2+) concentration; peak activity of these enzymes was recorded in the 3 mg L(-1) Cd(2+)-treatment group. These results show that Cd-induced oxidative damage can both induce, and aggravate, apoptosis in the hepatopancreatic cells of clams, even at Cd(2+) concentrations far below the semi-lethal dose for adult clams. The observed changes in caspase-3 activity enhanced significantly at lower Cd(2+) concentrations, indicating that caspase-3 is a suitable biomarker for heavy metal pollution, especially cadmium pollution, in marine organisms.
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