Evidence map›Paper›PMID 27038312›Full record

ReviewMycopathologia2016

Meningitis Caused by Candida Dubliniensis in a Patient with Cirrhosis: A Case Report and Review of the Literature.

Atsuko Yamahiro, K H Vincent Lau, David R Peaper, Merceditas Villanueva

Abstract readCase ReportsReview
PubMed Publisher
In one paragraph

Review in Mycopathologia, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
2.2field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 29 citations in OpenAlex.

  1. Trial
  2. Review
  3. Pediatric reports · 2026
    Article
  4. Article
  5. Meningitis caused byMedical mycology case reports · 2024
    Article
  6. Neurology. Clinical practice · 2024
    Article
  7. Review
  8. Fungal infections in liver cirrhosis.Translational gastroenterology and hepatology · 2024
    Review
  9. A Repertoire of the Less Common Clinical Yeasts.Journal of fungi (Basel, Switzerland) · 2023
    Review
  10. Article
  11. IDCases · 2023
    Article
  12. [Characteristics and research progress on the role of intestinal fungi in chronic liver disease].Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology · 2022
    Article
  13. Single and Repeated Episodes ofFrontiers in microbiology · 2021
    Article
  14. Article
  15. Fatal chronic meningitis caused byMedical mycology case reports · 2020
    Article
  16. Case Report:Frontiers in neurology · 2020
    Article
  17. First Reported Case ofCase reports in cardiology · 2020
    Article
  18. ChronicMedical mycology case reports · 2019
    Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Atsuko YamahiroInternal Medicine, Yale New Haven Hospital, New Haven, CT, 06510, USA. atsuko.yamahiro@yale.edu.
K H Vincent LauNeurology, Yale New Haven Hospital, New Haven, CT, 06510, USA.
David R PeaperDepartment of Laboratory Medicine, Yale New Haven Hospital, New Haven, CT, 06510, USA.
Merceditas VillanuevaInfectious Diseases, Yale University School of Medicine, New Haven, CT, 06510, USA.
Yale New Haven Hospital · USYale University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Candida species, including Candida dubliniensis, are a rare cause of meningitis. Herein, we report the second case of C. dubliniensis meningitis in a 49-year-old man with a history of hepatitis C virus-related cirrhosis, substance use disorder, and recent exposure to intravenous antibiotic therapy, presenting with confusion, abnormal gait, and urinary incontinence. Magnetic resonance imaging (MRI) of the brain showed marked hydrocephalus and leptomeningeal enhancement. Initial cerebrospinal fluid (CSF) studies were concerning for bacterial meningitis, although cultures were negative. Despite empiric treatment with broad-spectrum antibiotics, the patient's mental status declined. The diagnosis of C. dubliniensis meningitis was not made until the third lumbar puncture. The patient was treated with liposomal amphotericin B and flucytosine. Despite improvement of hydrocephalus on MRI of the brain and sterilization of CSF, the patient's mental status declined and he expired. This case highlights the difficulty in the diagnosis of C. dubliniensis meningitis as multiple lumbar punctures may be necessary. C. dubliniensis meningitis should be considered in the differential diagnosis for a patient with risk factors such as end-stage liver disease, human immunodeficiency virus infection, recent chemotherapy, substance use disorders, and recent broad-spectrum antibiotic use. A high index of suspicion is necessary as delay in initiation of therapy is associated with high mortality. The optimal treatment strategy has not been determined.

Indexed as

Amphotericin BAntifungal AgentsBrainCandidaCandidiasisCerebrospinal FluidFatal OutcomeFlucytosineHepatitis C, ChronicHumansLiver CirrhosisMagnetic Resonance ImagingMaleMeningitisMiddle AgedSubstance-Related DisordersAmphotericin BAntifungal AgentsFlucytosineliposomal amphotericin BCandida dubliniensisCirrhosisFungal meningitisHydrocephalusMeningitis

Identifiers

PMID27038312
OpenAlexW2322520690

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.