Trial reportBritish journal of clinical pharmacology2016
Acute p-synephrine ingestion increases fat oxidation rate during exercise.
Trial report in British journal of clinical pharmacology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it, 45 citations in OpenAlex.
- The Safety and Efficacy ofNutrients · 2022Pooled it
- The OMNIVEG Study: Effects of Transitioning from a Traditional to a Vegan Mediterranean Diet on Fat Oxidation During Exercise.Nutrients · 2025Trial
- The effects of a thermogenic supplement on metabolic and hemodynamic variables and subjective mood states.Journal of the International Society of Sports Nutrition · 2023Trial
- Does the Time of Day Play a Role in the Acute Effect ofNutrients · 2022Trial
- Effect ofNutrients · 2022Trial
- Trial
- Acute p-synephrine ingestion increases whole-body fat oxidation during 1-h of cycling at Fatmax.European journal of nutrition · 2020Trial
- Effects of ingesting a pre-workout dietary supplement with and without synephrine for 8 weeks on training adaptations in resistance-trained males.Journal of the International Society of Sports Nutrition · 2017Trial
- Effects of acute ingestion of a pre-workout dietary supplement with and withoutJournal of the International Society of Sports Nutrition · 2017Trial
- Acute p-synephrine ingestion increases fat oxidation rate during exercise.British journal of clinical pharmacology · 2016Trial
- Article
- Pre-Workout Supplements and Their Effects on Cardiovascular Health: An Integrative Review.Journal of cardiovascular development and disease · 2025Review
- p-Synephrine: an overview of physicochemical properties, toxicity, biological and pharmacological activity.EXCLI journal · 2025Review
- Roles of citrus fruits on energy expenditure, body weight management, and metabolic biomarkers: a comprehensive review.Nutrition reviews · 2024Review
- Application of Synephrine to Grape Increases Anthocyanin via Production of Hydrogen Peroxide, Not Phytohormones.International journal of molecular sciences · 2024Article
- Dietary supplementation habits in international natural bodybuilders during pre-competition.Heliyon · 2024Article
- Synephrine and Its Derivative Compound A: Common and Specific Biological Effects.International journal of molecular sciences · 2023Review
- Effect of 3 and 6 mg/kg of caffeine on fat oxidation during exercise in healthy active females.Biology of sport · 2023Article
- Review
- Wen Dan Tang: A Potential Jing Fang Decoction for Headache Disorders?Medicines (Basel, Switzerland) · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimsp-Synephrine is a protoalkaloid widely used in dietary supplements for weight management because of its purported thermogenic effects. However, there is a lack of scientific information about its effectiveness to increase fat metabolism during exercise. The purpose of this investigation was to determine the effects of an acute ingestion of p-synephrine on fat oxidation at rest and during exercise.
methodsIn a double-blind, randomized and counterbalanced experimental design, 18 healthy subjects performed two acute experimental trials after the ingestion of p-synephrine (3 mg kg(-1) ) or after the ingestion of a placebo (cellulose). Energy expenditure and fat oxidation rates were measured by indirect calorimetry at rest and during a cycle ergometer ramp exercise test (increases of 25 W every 3 min) until volitional fatigue.
resultsIn comparison with the placebo, the ingestion of p-synephrine did not change energy consumption (1.6 ± 0.3 vs. 1.6 ± 0.3 kcal min(-1) ; P = 0.69) or fat oxidation rate at rest (0.08 ± 0.02 vs. 0.10 ± 0.04 g min(-1) ; P = 0.15). However, the intake of p-synephrine moved the fat oxidation-exercise intensity curve upwards during the incremental exercise (P < 0.05) without affecting energy expenditure. Moreover, p-synephrine increased maximal fat oxidation rate (0.29 ± 0.15 vs. 0.40 ± 0.18 g min(-1) ; P = 0.01) during exercise although it did not affect the intensity at which maximal fat oxidation was achieved (55.8 ± 7.7 vs. 56.7 ± 8.2% VO2peak ; P = 0.51).
conclusionsThe acute ingestion of p-synephrine increased the fat oxidation rate while it reduced the carbohydrate oxidation rate when exercising at low-to-moderate exercise intensities.
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