ArticleObesity surgery2016
Roux-en-Y Gastric Bypass Surgery Suppresses Hepatic Gluconeogenesis and Increases Intestinal Gluconeogenesis in a T2DM Rat Model.
Article in Obesity surgery, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 40 citations in OpenAlex.
- Safety and efficacy of laparoscopic sleeve gastrectomy in adolescents with Grade V obesity (BMI ≥ 50 kg/mClinics (Sao Paulo, Brazil) · 2026Article
- Gastrectomy promoted diabetes remission involves the molecular clock and epigenetic mechanisms in a rat model of lean type 2 diabetes.Scientific reports · 2025Article
- Intestinal gluconeogenesis: metabolic benefits make sense in the light of evolution.Nature reviews. Gastroenterology & hepatology · 2023Review
- Glucose metabolism after bariatric surgery: implications for T2DM remission and hypoglycaemia.Nature reviews. Endocrinology · 2023Review
- Roux-en-Y Gastric Bypass Improves Insulin Sensitivity in Obese Rats with Type 2 Diabetes Mellitus by Regulating the Grin3a/AMPK Signal Axis in Hypothalamic Arcuate Nucleus.Diabetes, metabolic syndrome and obesity : targets and therapy · 2023Article
- Intestinal gluconeogenesis is downregulated in pediatric patients with celiac disease.BMC medicine · 2022Article
- Intestinal gluconeogenesis shapes gut microbiota, fecal and urine metabolome in mice with gastric bypass surgery.Scientific reports · 2022Article
- Sleeve Gastrectomy Suppresses Hepatic Glucose Production and Increases Hepatic Insulin Clearance Independent of Weight Loss.Diabetes · 2021Article
- Metabolic surgery in China: present and future.Journal of molecular cell biology · 2021Article
- Mechanisms linking gut microbial metabolites to insulin resistance.World journal of diabetes · 2021Review
- Roux-en-Y Gastric Bypass Improves Hepatic Glucose Metabolism Involving Upregulation of Sirt1 in Type 2 Diabetes Mellitus.Diabetes, metabolic syndrome and obesity : targets and therapy · 2021Article
- Portal Venous Metabolite Profiling After RYGB in Male Rats Highlights Changes in Gut-Liver Axis.Journal of the Endocrine Society · 2020Article
- Jejunal Insulin Signalling Is Increased in Morbidly Obese Subjects with High Insulin Resistance and Is Regulated by Insulin and Leptin.Journal of clinical medicine · 2020Article
- Metabolic benefits of gastric bypass surgery in the mouse: The role of fecal losses.Molecular metabolism · 2020Article
- Putting the Hindgut Hypothesis to the Test in a Diabetic Zucker Rat Model.Obesity surgery · 2019Article
- Roux-en-Y Gastric Bypass Improves Metabolic Conditions in Association with Increased Serum Bile Acids Level and Hepatic Farnesoid X Receptor Expression in a T2DM Rat Model.Obesity surgery · 2019Article
- Additional effects of duodenojejunal bypass on glucose metabolism in a rat model of sleeve gastrectomy.Surgery today · 2019Article
- Weight-Independent Mechanisms of Glucose Control After Roux-en-Y Gastric Bypass.Frontiers in endocrinology · 2018Review
- Intestinal SIRT3 overexpression in mice improves whole body glucose homeostasis independent of body weight.Molecular metabolism · 2017Article
- Physiological and molecular responses to bariatric surgery: markers or mechanisms underlying T2DM resolution?Annals of the New York Academy of Sciences · 2017Review
Corrections and comments
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Authors and funding
12 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundRoux-en-Y gastric bypass (RYGB) is an effective surgical treatment for type 2 diabetes mellitus (T2DM). The present study aimed to investigate the effects of RYGB on glucose homeostasis, lipid metabolism, and intestinal morphological adaption, as well as hepatic and intestinal gluconeogenesis.
methodsTwenty adult male T2DM rats induced by high-fat diet and low dose of streptozotocin were randomly divided into sham and RYGB groups. The parameters of body weight, food intake, glucose tolerance, insulin sensitivity, and serum lipid profiles were assessed to evaluate metabolic changes. Intestinal sections were stained with hematoxylin and eosin (H&E) for light microscopy examination. The messenger RNA (mRNA) and protein expression levels of key regulatory enzymes of gluconeogenesis [phosphoenolpyruvate carboxykinase (PEPCK), glucose-6-phosphatase (G6Pase)] were determined through reverse-transcription PCR (RT-PCR) and Western blotting, respectively.
resultsRYGB induced significant improvements in glucose tolerance and insulin sensitivity, along with weight loss and decreased food intake. RYGB also decreased serum triglyceride (TG) and free fatty acid (FFA) levels. The jejunum and ileum exhibited a marked increase in the length and number of intestinal villi after RYGB. The RYGB group exhibited downregulated mRNA and protein expression levels of PEPCK and G6Pase in the liver and upregulated expression of these enzymes in the jejunum and ileum tissues.
conclusionsRYGB ameliorates glucose and lipid metabolism accompanied by weight loss and calorie restriction. The small intestine shows hyperplasia and hypertrophy after RYGB. Meanwhile, our study demonstrated that the reduced hepatic gluconeogenesis and increased intestinal gluconeogenesis may contribute to improved glucose homeostasis after RYGB.
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