ArticleDevelopment genes and evolution2016
The sex-limited effects of mutations in the EGFR and TGF-β signaling pathways on shape and size sexual dimorphism and allometry in the Drosophila wing.
Article in Development genes and evolution, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
8 citing papers in PubMed, 25 citations in OpenAlex.
- MAPPER: An Open-Source, High-Dimensional Image Analysis Pipeline Unmasks Differential Regulation ofFrontiers in genetics · 2022Article
- The gut-microbiota-brain axis in autism: what Drosophila models can offer?Journal of neurodevelopmental disorders · 2021Review
- Sex-specific plasticity and the nutritional geometry of insulin-signaling gene expression in Drosophila melanogaster.EvoDevo · 2021Article
- Drosophila models of pathogenic copy-number variant genes show global and non-neuronal defects during development.PLoS genetics · 2020Article
- Notch signaling patterns head horn shape in the bull-headed dung beetle Onthophagus taurus.Development genes and evolution · 2020Article
- Why does allometry evolve so slowly?Integrative and comparative biology · 2019Article
- Regulation of Drosophila Lifespan by bellwether Promoter Alleles.Scientific reports · 2017Article
- In vivo severity ranking of Ras pathway mutations associated with developmental disorders.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 2 countries.
Funding
Abstract
Much of the morphological diversity in nature-including among sexes within a species-is a direct consequence of variation in size and shape. However, disentangling variation in sexual dimorphism for both shape (SShD), size (SSD), and their relationship with one another remains complex. Understanding how genetic variation influences both size and shape together, and how this in turn influences SSD and SShD, is challenging. In this study, we utilize Drosophila wing size and shape as a model system to investigate how mutations influence size and shape as modulated by sex. Previous work has demonstrated that mutations in epidermal growth factor receptor (EGFR) and transforming growth factor-β (TGF-β) signaling components can influence both wing size and shape. In this study, we re-analyze this data to specifically address how they impact the relationship between size and shape in a sex-specific manner, in turn altering the pattern of sexual dimorphism. While most mutations influence shape overall, only a subset have a genotypic specific effect that influences SShD. Furthermore, while we observe sex-specific patterns of allometric shape variation, the effects of most mutations on allometry tend to be small. We discuss this within the context of using mutational analysis to understand sexual size and shape dimorphism.
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Registered trials
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