Observational studyPaediatric and perinatal epidemiology2016
Umbilical Cord Serum 25-Hydroxyvitamin D Concentrations and Relation to Birthweight, Head Circumference and Infant Length at Age 14 Days.
Observational study in Paediatric and perinatal epidemiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 3 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- The role of vitamin D deficiency in fetal growth restriction: a systematic review.Frontiers in medicine · 2025Pooled it
- Maternal vitamin D and growth of under-five children: a systematic review and meta-analysis of observational and interventional studies.Global health action · 2022Pooled it
- Vitamin D status during pregnancy and offspring outcomes: a systematic review and meta-analysis of observational studies.European journal of clinical nutrition · 2020Pooled it
- Vitamin D Status of Infants of Mothers with Gestational Diabetes: Status at Birth and a Randomized Controlled Trial of Vitamin D Supplementation across Infancy.The Journal of nutrition · 2022Trial
- Vitamin D status in Faroese adults and its association with inflammatory bowel diseases - a cross-sectional study from the FarGen 2 project.International journal of circumpolar health · 2025Article
- The Molecular Biology of Placental Transport of Calcium to the Human Foetus.International journal of molecular sciences · 2025Review
- Health effects associated with measured contaminants in the Arctic: short communication.International journal of circumpolar health · 2024Article
- Are Maternal Vitamin D (25(OH)D) Levels a Predisposing Risk Factor for Neonatal Growth? A Cross-Sectional Study.Clinics and practice · 2024Article
- Cord blood vitamin A and vitamin D levels in relation to physical growth in exclusively breastfed infants aged 0-6 months.Frontiers in endocrinology · 2024Observational
- Maternal exposure to perfluoroalkyl chemicals and anogenital distance in the offspring: A Faroese cohort study.Reproductive toxicology (Elmsford, N.Y.) · 2021Article
- Screening of vitamin D and calcium concentrations in neonates of mothers at high risk of vitamin D deficiency.BMC pediatrics · 2020Article
- Dietary risk factors for inflammatory bowel diseases in a high-risk population: Results from the Faroese IBD study.United European gastroenterology journal · 2019Article
- Vitamin D Trajectories From Birth to Early Childhood and Elevated Systolic Blood Pressure During Childhood and Adolescence.Hypertension (Dallas, Tex. : 1979) · 2019Article
- Cord serum 25-hydroxyvitamin D is not associated with cranial anthropometrics in infants up to 6 months of age. An Odense Child Cohort study.Journal of bone and mineral metabolism · 2018Article
- Maternal and Cord Blood Vitamin D Status and Anthropometric Measurements in Term Newborns at Birth.Frontiers in endocrinology · 2018Article
- Estimated exposures to perfluorinated compounds in infancy predict attenuated vaccine antibody concentrations at age 5-years.Journal of immunotoxicology · 2017Article
- Gestational diabetes and offspring birth size at elevated environmental pollutant exposures.Environment international · 2017Article
- [Vitamin D level at birth and influencing factors in preterm infants].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2017Article
- Secondary sex ratio in relation to exposures to polychlorinated biphenyls, dichlorodiphenyl dichloroethylene and methylmercury.International journal of circumpolar health · 2017Article
- Body weight and 25-hidroxyvitamin D follicular levels: a prospective study of women submitted to in vitro fertilization.JBRA assisted reproduction · 2016Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
backgroundInsufficient supply of vitamin D during early development may negatively affect offspring growth.
methodsWe examined the association between umbilical cord (UC) serum 25-hydroxyvitamin D (25(OH)D) concentrations and infant size in a study of two Faroese birth cohorts of 1038 singleton infants. In the third trimester, the pregnant women completed questionnaires, and clinical examination included birthweight, head circumference, and infant length at age 14 days.
resultsFifty-three percent of the newborn population had UC 25(OH)D < 25 nmol/L as determined by LC-MS/MS. Using multiple linear regression models with adjustment for pre-pregnancy BMI, sex, parity, gestational age, or infant age at examination, season of birth, smoking, gestational diabetes, examiner, and cohort identity, we found no relationship between birthweight or head circumference and UC 25(OH)D. However, infants with vitamin D status <12 nmol/L had a 0.49 (95% confidence interval 0.05, 0.93) cm lower length than infants with vitamin D status >50 nmol/L in models further adjusted for birthweight.
conclusionOur data suggest that umbilical cord serum 25(OH)D concentrations are positively associated with infant length but not with birthweight and head circumference. Although the paediatric relevance of the observed association is unclear, the possible long-term consequences of late-pregnancy hypovitaminosis D deserve attention.
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