ArticleHuman brain mapping2016
Asymmetry in functional connectivity of the human habenula revealed by high-resolution cardiac-gated resting state imaging.
Article in Human brain mapping, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 3 of them syntheses that pooled it.
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Who cites it
36 citing papers in PubMed, 3 syntheses or guidelines pooled it, 67 citations in OpenAlex.
- Investigation of habenula volume in mood disorders: A meta-analytic study.Psychological medicine · 2026Pooled it
- The habenula in mood disorders: A systematic review of human studies.Molecular psychiatry · 2025Pooled it
- Significant heterogeneity in structural asymmetry of the habenula in the human brain: A systematic review and meta-analysis.Human brain mapping · 2023Pooled it
- Habenula Connectivity and Intravenous Ketamine in Treatment-Resistant Depression.The international journal of neuropsychopharmacology · 2021Trial
- Asymmetrical modulation of fear expression via GABAProceedings of the National Academy of Sciences of the United States of America · 2026Article
- Habenula volume alterations in adults born very preterm.Scientific reports · 2026Article
- Heart Rate Variability Biofeedback Alleviates Subthreshold Depression by Reconstructing the Brain-Heart Axis via Habenular Network Functional Connectivity Modulation.CNS neuroscience & therapeutics · 2025Article
- The Neuroanatomy of the Habenular Complex and Its Role in the Regulation of Affective Behaviors.Journal of functional morphology and kinesiology · 2024Review
- Altered habenular connectivity in chronic low back pain: An fMRI and machine learning study.Human brain mapping · 2023Article
- Decreased resting-state functional connectivity of the habenula-cerebellar in a major depressive disorder.Frontiers in psychiatry · 2022Article
- Multi-level variations of lateral habenula in depression: A comprehensive review of current evidence.Frontiers in psychiatry · 2022Review
- N-Methyl D-aspartate receptor subtype 2B/CaFrontiers in cellular neuroscience · 2022Article
- Current Understanding of the Neural Circuitry in the Comorbidity of Chronic Pain and Anxiety.Neural plasticity · 2022Review
- Reduced habenular volumes and neuron numbers in male heroin addicts: a post-mortem study.European archives of psychiatry and clinical neuroscience · 2021Article
- Evidence of Altered Habenular Intrinsic Functional Connectivity in Pediatric ADHD.Journal of attention disorders · 2021Article
- Effects of an Allostatic Closed-Loop Neurotechnology (HIRREM) on Brain Functional Connectivity Laterality in Military-Related Traumatic Stress.Journal of neuroimaging : official journal of the American Society of Neuroimaging · 2021Article
- Thalamo-Habenular Connection Differences Between Patients With Major Depressive Disorder and Normal Controls.Frontiers in psychiatry · 2021Article
- Left-right asymmetric and smaller right habenula volume in major depressive disorder on high-resolution 7-T magnetic resonance imaging.PloS one · 2021Article
- Tacr3 in the lateral habenula differentially regulates orofacial allodynia and anxiety-like behaviors in a mouse model of trigeminal neuralgia.Acta neuropathologica communications · 2020Article
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Corrections and comments
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
Abstract
The habenula is a hub for cognitive and emotional signals that are relayed to the aminergic centers in the midbrain and, thus, plays an important role in goal-oriented behaviors. Although it is well described in rodents and non-human primates, the habenula functional network remains relatively uncharacterized in humans, partly because of the methodological challenges associated with the functional magnetic resonance imaging of small structures in the brain. Using high-resolution cardiac-gated resting state imaging in healthy humans and precisely identifying each participants' habenula, we show that the habenula is functionally coupled with the insula, parahippocampus, thalamus, periaqueductal grey, pons, striatum and substantia nigra/ventral tegmental area complex. Furthermore, by separately examining and comparing the functional maps from the left and right habenula, we provide the first evidence of an asymmetry in the functional connectivity of the habenula in humans. Hum Brain Mapp 37:2602-2615, 2016. © 2016 The Authors Human Brain Mapping Published by Wiley Periodicals, Inc.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.