ArticlePsychopharmacology2016
Threshold dose for discrimination of nicotine via cigarette smoking.
Article in Psychopharmacology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Switching from menthol to non-menthol cigarettes does not impact acute responses to intravenous nicotine.Pharmacology, biochemistry, and behavior · 2025Trial
- Comparison between Gradual Reduced Nicotine Content and Usual Nicotine Content Groups on Subjective Cigarette Ratings in a Randomized Double-Blind Trial.International journal of environmental research and public health · 2020Trial
- The Impact of Gradual and Immediate Nicotine Reduction on Subjective Cigarette Ratings.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2019Trial
- Preliminary validity of the modified Cigarette Evaluation Questionnaire in predicting the reinforcing effects of cigarettes that vary in nicotine content.Experimental and clinical psychopharmacology · 2017Trial
- Pulsed nicotine infusions as a model for smoking: validating a tool to explore nicotine thresholds in humans.Psychopharmacology · 2024Article
- Threshold for the pleasurable effects of nicotine are lower than its reinforcing effects during self-administration.Experimental and clinical psychopharmacology · 2023Article
- Acute nicotine reinforcement requires ability to discriminate the stimulus effects of nicotine.Experimental and clinical psychopharmacology · 2022Review
- A review of the evidence on cigarettes with reduced addictiveness potential.The International journal on drug policy · 2022Review
- Acute subjective sensory perceptions predict relative reinforcing effects of smoked nicotine.Addictive behaviors · 2021Article
- Reducing the relative value of cigarettes: Considerations for nicotine and non-nicotine factors.Neuropharmacology · 2020Review
- Research on Behavioral Discrimination of Nicotine May Inform FDA Policy on Setting a Maximum Nicotine Content in Cigarettes.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2019Article
- Animal Research on Nicotine Reduction: Current Evidence and Research Gaps.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2017Article
- Preliminary test of cigarette nicotine discrimination threshold in non-dependent versus dependent smokers.Drug and alcohol dependence · 2017Article
- Threshold dose for behavioral discrimination of cigarette nicotine content in menthol vs. non-menthol smokers.Psychopharmacology · 2017Article
- Response to varying the nicotine content of cigarettes in vulnerable populations: an initial experimental examination of acute effects.Psychopharmacology · 2017Article
- How Intravenous Nicotine Administration in Smokers Can Inform Tobacco Regulatory Science.Tobacco regulatory science · 2016Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
rationaleThe lowest nicotine threshold "dose" in cigarettes discriminated from a cigarette containing virtually no nicotine may help inform the minimum dose maintaining dependence.
objectivesSpectrum research cigarettes (from NIDA) differing in nicotine content were used to evaluate a procedure to determine discrimination thresholds.
methodsDependent smokers (n = 18; 13 M, 5 F) were tested on ability to discriminate cigarettes with nicotine contents of 11, 5, 2.4, and 1.3 mg/g, one per session, from the "ultralow" cigarette with 0.4 mg/g, after having discriminated 16 mg/g from 0.4 mg/g (all had 9-10 mg "tar"). Exposure to each was limited to 4 puffs/trial. All subjects were abstinent from smoking overnight prior to each session, and the number of sessions was determined by the participant's success in discrimination behavior on >80 % of trials. Subjective perceptions and behavioral choice between cigarettes were also assessed and related to discrimination behavior.
resultsThe median threshold was 11 mg/g, but the range was 2.4 to 16 mg/g, suggesting wide variability in discrimination threshold. Compared to the ultralow, puff choice was greater for the subject's threshold dose but only marginal for the subthreshold (next lowest nicotine) cigarette. Threshold and subthreshold also differed on subjective perceptions but not withdrawal relief.
conclusionsUnder these testing conditions, threshold content for discriminating nicotine via cigarettes may be 11 mg/g or greater for most smokers, but some can discriminate nicotine contents one-half or one-quarter this amount. Further study with other procedures and cigarette exposure amounts may identify systematic differences in nicotine discrimination thresholds.
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