Evidence map›Paper›PMID 27037828›Full record

ArticleNaunyn-Schmiedeberg's archives of pharmacology2016

Wound healing modulation by a latex protein-containing polyvinyl alcohol biomembrane.

Márcio V Ramos, Nylane Maria N de Alencar, Raquel S B de Oliveira, Lyara B N Freitas, Karoline S Aragão, Thiago Antônio M de Andrade, Marco Andrey C Frade, Gerly Anne C Brito, Ingrid Samantha T de Figueiredo

Open access · greenAbstract read
PubMed Publisher
In one paragraph

Article in Naunyn-Schmiedeberg's archives of pharmacology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.2field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 16 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Márcio V RamosDepartamento de Bioquímica e Biologia Molecular/UFC Campus do Pici 6033, Fortaleza, Ceará, Brazil. r_marcio@hotmail.com.
Nylane Maria N de AlencarDepartamento de Fisiologia e Farmacologia/UFC, Fortaleza, Ceará, Brazil.
Raquel S B de OliveiraCentro Universitário Estácio do Ceará, Via Corpvs, Fortaleza, Ceará, Brazil.
Lyara B N FreitasDepartamento de Fisiologia e Farmacologia/UFC, Fortaleza, Ceará, Brazil.
Karoline S AragãoDepartamento de Fisiologia e Farmacologia/UFC, Fortaleza, Ceará, Brazil.
Thiago Antônio M de AndradeDivisão de Dermatologia, Faculdade de Medicina de Ribeirão Preto, São Paulo, Brazil.
Marco Andrey C FradeDivisão de Dermatologia, Faculdade de Medicina de Ribeirão Preto, São Paulo, Brazil.
Gerly Anne C BritoDepartamento de Morfologia/UFC, Fortaleza, Ceará, Brazil.
Ingrid Samantha T de FigueiredoCentro Universitário Estácio do Ceará, Via Corpvs, Fortaleza, Ceará, Brazil.
Universidade Federal do Ceará · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In a previous study, we performed the chemical characterization of a polyvinyl alcohol (PVA) membrane supplemented with latex proteins (LP) displaying wound healing activity, and its efficacy as a delivery system was demonstrated. Here, we report on aspects of the mechanism underlying the performance of the PVA-latex protein biomembrane on wound healing. LP-PVA, but not PVA, induced more intense leukocyte (neutrophil) migration and mast cell degranulation during the inflammatory phase of the cicatricial process. Likewise, LP-PVA induced an increase in key markers and mediators of the inflammatory response (myeloperoxidase activity, nitric oxide, TNF, and IL-1β). These results demonstrated that LP-PVA significantly accelerates the early phase of the inflammatory process by upregulating cytokine release. This remarkable effect improves the subsequent phases of the healing process. The polyvinyl alcohol membrane was fully absorbed as an inert support while LP was shown to be active. It is therefore concluded that the LP-PVA is a suitable bioresource for biomedical engineering.

Indexed as

CalotropisDrug CarriersMembranes, ArtificialAdministration, CutaneousAnimalsCell DegranulationDisease Models, AnimalDrug CompoundingInflammation MediatorsInterleukin-1betaLatexMacrophage ActivationMast CellsMiceNeutrophil InfiltrationNitric OxideDrug CarriersIL1B protein, mouseInflammation MediatorsInterleukin-1betaLatexMembranes, ArtificialNitric OxidePeroxidasePlant ProteinsPolyvinyl AlcoholTumor Necrosis Factor-alphaBiomembraneCalotropis proceraPolyvinyl alcoholWound

Identifiers

PMID27037828
OpenAlexW2317657769

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.