Evidence map›Paper›PMID 27037786›Full record

ReviewAnnals of the New York Academy of Sciences2016

Restructuring reward processing with Mindfulness-Oriented Recovery Enhancement: novel therapeutic mechanisms to remediate hedonic dysregulation in addiction, stress, and pain.

Eric L Garland

Registry-linked trialAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Annals of the New York Academy of Sciences, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06739304 (The Effectiveness of Mindfulness-based Relapse Prevention), which is not on this map. Cited by 66 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
66citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06739304 nacompletednot on this mapstarted 2023, after this paper: background citation

The Effectiveness of Mindfulness-based Relapse Prevention: A Randomized Controlled Trial Study

TypeinterventionalSponsorSir Run Run Shaw HospitalRan2023 to 2023Enrolled1,200ConditionsSubstance Use DisorderArmsMindfulness-based Relapse Prevention
3 · Its place in the literature

Who cites it

66 citing papers in PubMed, 3 syntheses or guidelines pooled it.

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  12. Mindfulness-oriented recovery enhancement for internet gaming disorder in U.S. adults: A stage I randomized controlled trial.Psychology of addictive behaviors : journal of the Society of Psychologists in Addictive Behaviors · 2017
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6 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author.

Eric L GarlandCollege of Social Work, University of Utah, and Supportive Oncology and Survivorship, Huntsman Cancer Institute, Salt Lake City, Utah.

Funding

Targeting Hedonic Dysregulation to Address Chronic Pain and Opioid Misuse in Primary Care.R01DA042033 · NIDA · UNIVERSITY OF UTAH · PI GARLAND, ERIC LEE · 2016 to 2020
$2.8M
Targeting Military Opioid Misuse with Mindfulness-Oriented Recovery EnhancementR34DA037005 · NIDA · UNIVERSITY OF UTAH · PI GARLAND, ERIC LEE · 2013 to 2015
$667k
NIDA NIH HHS R01 DA042033NIDA NIH HHS R34 DA037005
6 · The paper itself

Abstract

Though valuation processes are fundamental to survival of the human species, hedonic dysregulation is at the root of an array of maladies, including addiction, stress, and chronic pain, as evidenced by the allostatic shift in the relative salience of natural reward to drug reward observed among persons with severe substance use disorders. To address this crucial problem, novel interventions are needed to restore hedonic regulatory processes gone awry in persons exhibiting addictive behaviors. This article describes a theoretical rationale and empirical evidence for the effects of one such new intervention, Mindfulness-Oriented Recovery Enhancement (MORE), on top-down and bottom-up mechanisms implicated in cognitive control and hedonic regulation. MORE is innovative and distinct from extant mindfulness-based interventions in that it unites traditional mindfulness meditation with reappraisal and savoring strategies designed to reverse the downward shift in salience of natural reward relative to drug reward, representing a crucial tipping point to disrupt the progression of addiction-a mechanistic target that no other behavioral intervention has been designed to address. Though additional studies are needed, clinical and biobehavioral data from several completed and ongoing trials suggest that MORE may exert salutary effects on addictive behaviors and the neurobiological processes that underpin them.

Indexed as

MeditationMindfulnessRewardBehavior, AddictiveChronic PainHumansStress, PsychologicalTreatment Outcomeaddictionallostasismindfulnessreappraisalrewardsavoring

Identifiers

PMID27037786
PMCPMC4940274

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.