ReviewBritish journal of clinical pharmacology2017
Atheroprotective effects of conjugated linoleic acid.
Review in British journal of clinical pharmacology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04728399 (Effects of Soy Peptide and Conjugated Linoleic Acid on Body Composition), which is not on this map. Cited by 27 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effects of Soy Peptide and Conjugated Linoleic Acid on Body Composition: a Double-blind, Randomized, Placebo-controlled Clinical Trial
Who cites it
27 citing papers in PubMed, 1 synthesis or guideline pooled it, 71 citations in OpenAlex.
- A global analysis of dairy consumption and incident cardiovascular disease.Nature communications · 2025Pooled it
- Natural Bioactive Compounds in Sheep Milk: Potential Biomedical Applications.Current issues in molecular biology · 2025Review
- Polyunsaturated fatty acids promote M2-like TAM deposition via dampening RhoA-YAP1 signaling in the ovarian cancer microenvironment.Experimental hematology & oncology · 2024Article
- Article
- Growth performance, meat quality and hematological parameters of broiler chickens fed safflower seed.Tropical animal health and production · 2024Article
- A dietary intervention with conjugated linoleic acid enhances microstructural white matter reorganization in experimental stroke.Frontiers in neurology · 2024Article
- Healthy Effects of Milk and Dairy Product Consumption in the Mediterranean Area and Japan.Endocrine, metabolic & immune disorders drug targets · 2024Review
- Conjugated linoleic acid and glucosamine supplements may prevent bone loss in aging by regulating the RANKL/RANK/OPG pathway.Molecular biology reports · 2023Review
- Normal-Fat vs. High-Fat Diets and Olive Oil vs. CLA-Rich Dairy Fat: A Comparative Study of Their Effects on Atherosclerosis in Male Golden Syrian Hamsters.Metabolites · 2023Article
- Alleviation effect of conjugated linoleic acid on estradiol benzoate induced fatty liver hemorrhage syndrome in Hy-line male chickens.Journal of animal science · 2023Article
- Article
- Clinical, Nutritional, and Functional Evaluation of Chia Seed-Fortified Muffins.Molecules (Basel, Switzerland) · 2022Article
- Proteomics Insights into the Gene Network ofAnimals : an open access journal from MDPI · 2022Article
- Molecular mediators of the association between child obesity and mental health.Frontiers in genetics · 2022Article
- Article
- Importance of Bioactive Substances in Sheep's Milk in Human Health.International journal of molecular sciences · 2021Review
- Isomer-Specific Effects ofAnimals : an open access journal from MDPI · 2021Article
- Activation of Hair Cell Growth Factors by Linoleic Acid inMolecules (Basel, Switzerland) · 2021Article
- Physiological Characteristics ofJournal of microbiology and biotechnology · 2021Article
- A Progressive Nutrient Profiling System to Guide Improvements in Nutrient Density of Foods and Beverages.Frontiers in nutrition · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Atherosclerosis, the underlying cause of heart attack and strokes, is a progressive dyslipidaemic and inflammatory disease where monocyte-derived macrophage cells play a pivotal role. Although most of the mechanisms that contribute to the progression of atherosclerosis have been identified, there is limited information on those governing regression. Conjugated linoleic acid (CLA) is a generic term denoting a group of naturally occurring isomers of linoleic acid (18:2, n6) that differ in the position or geometry (i.e. cis or trans) of their double bonds. The most predominant isomers in ruminant fats are cis-9, trans-11 CLA (c9,t11-CLA), which accounts for more than 80% of CLA isomers in dairy products and trans-10, cis-12 CLA (t10,c12-CLA). Dietary administration of a blend of the two most abundant isomers of CLA has been shown to inhibit the progression and induce the regression of pre-established atherosclerosis. Studies investigating the mechanisms involved in CLA-induced atheroprotective effects are continually emerging. The purpose of this review is to discuss comprehensively the effects of CLA on monocyte/macrophage function in atherosclerosis and to identify possible mechanisms through which CLA mediates its atheroprotective effects.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.