ArticleJournal of clinical periodontology2016
Localized aggressive periodontitis immune response to healthy and diseased subgingival plaque.
Article in Journal of clinical periodontology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 39 citations in OpenAlex.
- Grade C molar-incisor pattern periodontitis classification and its challenges.Journal of periodontology · 2026Review
- The Evolution of Prepubertal Localized Aggressive Periodontitis in Primary and Mixed Dentition-Clinical Evidence.Journal of clinical medicine · 2026Article
- Facile minocycline deployment in gingiva using a dissolvable microneedle patch for the adjunctive treatment of periodontal disease.Bioengineering & translational medicine · 2025Article
- Review
- Molecular Analysis ofPathogens (Basel, Switzerland) · 2024Article
- One Year Follow-Up of a 4-Year-Old Caucasian Girl Diagnosed with Stage IV Grade C Localized Periodontitis.Journal of clinical medicine · 2024Article
- Grade C Molar-Incisor Pattern Periodontitis in Young Adults: What Have We Learned So Far?Pathogens (Basel, Switzerland) · 2024Review
- Case Report of a 4-Year-Old Girl with Stage IV Grade C Localized Periodontitis (Pre-Puberal Localized Aggressive Periodontitis) Affected by Misrecognition and Late Diagnosis.Journal of clinical medicine · 2024Article
- Effects of G-CSF on hPDLSC proliferation and osteogenic differentiation in the LPS-induced inflammatory microenvironment.BMC oral health · 2023Article
- Recent progress and perspectives on the relationship between hyperuricemia and periodontitis.Frontiers in immunology · 2022Review
- Toll-Like Receptor Signaling and Immune Regulatory Lymphocytes in Periodontal Disease.International journal of molecular sciences · 2020Review
- Oral and Fecal Microbiome in Molar-Incisor Pattern Periodontitis.Frontiers in cellular and infection microbiology · 2020Article
- Associations ofJDR clinical and translational research · 2019Article
- Consistent and reproducible long-term in vitro growth of health and disease-associated oral subgingival biofilms.BMC microbiology · 2018Article
- Long-term clinical response to treatment and maintenance of localized aggressive periodontitis: a cohort study.Journal of clinical periodontology · 2017Article
- Cytokine response patterns to complex biofilms by mononuclear cells discriminate patient disease status and biofilm dysbiosis.Journal of oral microbiology · 2017Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
aimThe objective of this case-control study was to compare the inflammatory response of peripheral blood from localized aggressive periodontitis (LAP) patients when stimulated with healthy or diseased plaque samples. MATERIALS AND
methodsWhole blood and subgingival plaque samples were collected from 13 LAP subjects, 14 siblings of LAP subjects and six periodontally healthy individuals. Whole blood was stimulated for 24 h with plaque samples generated from healthy or diseased sites. The levels of 14 cyto/chemokines were detected using multiplex technology.
resultsLocalized aggressive periodontitis-derived cultures displayed higher levels of G-CSF, INFγ, IL10, IL12p40, IL1β, IL-6, IL-8, MCP-1, MIP-1α, and TNFα, than control cultures regardless of stimulus used. Whole blood from healthy siblings displayed higher levels of IL-6 compared to control subjects, but lower levels than those observed in cultures from LAP participants.
conclusionsThis study suggests that although bacteria is an important factor in eliciting the hyper-inflammatory response observed in LAP patients, the predisposition of host's response to bacterial presence may play a more significant role than the components of the stimulatory plaque.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.