ArticleAddiction biology2017
Distress tolerance among substance users is associated with functional connectivity between prefrontal regions during a distress tolerance task.
Article in Addiction biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 2 of them syntheses that pooled it.
What it found
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The trial behind it
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Who cites it
24 citing papers in PubMed, 2 syntheses or guidelines pooled it, 44 citations in OpenAlex.
- Pathological fear, anxiety and negative affect exhibit distinct neurostructural signatures: evidence from psychiatric neuroimaging meta-analysis.Translational psychiatry · 2022Pooled it
- Neuroimaging Impaired Response Inhibition and Salience Attribution in Human Drug Addiction: A Systematic Review.Neuron · 2018Pooled it
- Impact of a computerized distress intolerance intervention on electrocortical reactivity to cannabis and threat cues: A randomized controlled trial.Psychology of addictive behaviors : journal of the Society of Psychologists in Addictive Behaviors · 2022Trial
- Functional connectivity response to distress-inducing auditory feedback associated with short-term smoking abstinence.Drug and alcohol dependence · 2026Article
- Distress Intolerance Is Associated With a Greater Reward Positivity to Aversive Avoidance Feedback.Psychophysiology · 2026Article
- A shared ensemble in the prelimbic cortex links impulsivity and anxiety-like behavior.bioRxiv : the preprint server for biology · 2025Article
- Relapse risk, frustration tolerance, and motivational readiness for change in substance use disorders.BMC psychology · 2025Article
- Effects of Transcranial Magnetic Stimulation on Cognitive-Affective Task-Based Functional Connectivity.Brain connectivity · 2025Article
- Cognitive control: modeling the impact on mental health.Frontiers in psychology · 2025Article
- The effectiveness of acceptance and commitment therapy on identity crisis and distress tolerance in mothers of children with cancer.Journal of education and health promotion · 2024Article
- Heightened adolescent emotional reactivity in the brain is associated with lower future distress tolerance and higher depressive symptoms.Psychiatry research. Neuroimaging · 2023Article
- Sex differences in neuroendocrine, sympathetic nervous system, and affect responses to acute stress in cannabis users.Psychopharmacology · 2023Article
- Smoking status affects cognitive, emotional and neural-connectivity response to distress-inducing auditory feedback.Drug and alcohol dependence · 2023Article
- Prelimbic Cortex Activity during a Distress Tolerance Task Predicts Cocaine-Seeking Behavior in Male, But Not Female Rats.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- The Effect of Distress Tolerance Training on Problematic Internet Use and Psychological Wellbeing Among Faculty Nursing Students: A Randomized Control Trial.Psychology research and behavior management · 2023Article
- Lost in Translation: the Gap Between Neurobiological Mechanisms and Psychosocial Treatment Research for Substance Use Disorders.Current addiction reports · 2021Article
- Triple Network Resting State Connectivity Predicts Distress Tolerance and Is Associated with Cocaine Use.Journal of clinical medicine · 2019Article
- Distress tolerance trajectories following substance use treatment.Journal of consulting and clinical psychology · 2019Article
- A Roadmap for Integrating Neuroscience Into Addiction Treatment: A Consensus of the Neuroscience Interest Group of the International Society of Addiction Medicine.Frontiers in psychiatry · 2019Review
- Distress tolerance to auditory feedback and functional connectivity with the auditory cortex.Psychiatry research. Neuroimaging · 2018Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Distress tolerance (DT), defined as the ability to persist in goal directed behavior while experiencing affective distress, is implicated in the development and maintenance of substance use disorders. While theory and evidence indicate that cortico-limbic neural dysfunction may account for deficits in goal directed behavior while experiencing distress, the neurobiological mechanisms of DT have yet to be examined. We modified a computerized DT task for use in functional magnetic resonance imaging (fMRI), the Paced Auditory Serial Addition Task (PASAT-M), and examined the neural correlates and functional connectivity of DT among a cohort of substance users (n = 21; regular cocaine and nicotine users) and healthy controls (n = 25). In response to distress during the PASAT-M, we found greater activation in a priori cortico-limbic network ROIs, namely the right insula, anterior cingulate cortex (ACC), bilateral medial frontal gyrus (MFG), right inferior frontal gyrus (IFG) and right ventromedial prefrontal cortex (vmPFC) significantly predicted higher DT among substance users, but not healthy controls. In addition, greater task-specific functional connectivity during distress between the right MFG and bilateral vmPFC/sgACC was associated with higher DT among substance users, but not healthy controls. The observed positive relationship between DT and neural activation in cortico-limbic structures, as well as functional connectivity between the rMFG and vmPFC/sgACC, is in line with theory and research suggesting the importance of these structures for persisting in goal directed behavior while experiencing affective distress.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.