Evidence map›Paper›PMID 27037203›Full record

ArticleHPB : the official journal of the International Hepato Pancreato Biliary Association2016

The association of adjuvant therapy with survival at the population level following pancreatic adenocarcinoma resection.

Daniel J Kagedan, Ravish S Raju, Matthew E Dixon, Elizabeth Shin, Qing Li, Ning Liu, Maryam Elmi, Abraham El-Sedfy, Lawrence Paszat, Alexander Kiss and 3 more

Open access · bronzeAbstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in HPB : the official journal of the International Hepato Pancreato Biliary Association, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.6field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 7 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 7 institutions in 2 countries.

Daniel J KagedanDivision of General Surgery, Department of Surgery, University of Toronto, Toronto, ON, Canada.
Ravish S RajuSunnybrook Health Sciences Centre, Toronto, ON, Canada.
Matthew E DixonDepartment of Surgery, Maimonides Medical Center, Brooklyn, NY, USA.
Elizabeth ShinFaculty of Medicine, University of Toronto, Toronto, ON, Canada.
Qing LiInstitute for Clinical Evaluative Sciences, Toronto, ON, Canada.
Ning LiuInstitute for Clinical Evaluative Sciences, Toronto, ON, Canada.
Maryam ElmiDivision of General Surgery, Department of Surgery, University of Toronto, Toronto, ON, Canada.
Abraham El-SedfyDepartment of Surgery, Saint Barnabas Medical Center, Livingston, NJ, USA.
Lawrence PaszatSunnybrook Health Sciences Centre, Toronto, ON, Canada; Faculty of Medicine, University of Toronto, Toronto, ON, Canada; Institute for Clinical Evaluative Sciences, Toronto, ON, Canada.
Alexander KissSunnybrook Health Sciences Centre, Toronto, ON, Canada; Institute for Clinical Evaluative Sciences, Toronto, ON, Canada; Institute of Health Policy, Management & Evaluation, University of Toronto, Toronto, ON, Canada.
Craig C EarleSunnybrook Health Sciences Centre, Toronto, ON, Canada; Faculty of Medicine, University of Toronto, Toronto, ON, Canada; Institute for Clinical Evaluative Sciences, Toronto, ON, Canada.
Nicole MittmannHealth Outcomes and PharmacoEconomic (HOPE) Research Centre, Sunnybrook Research Institute, Toronto, ON, Canada.
Natalie G CoburnDivision of General Surgery, Department of Surgery, University of Toronto, Toronto, ON, Canada; Sunnybrook Health Sciences Centre, Toronto, ON, Canada; Faculty of Medicine, University of Toronto, Toronto, ON, Canada; Institute for Clinical Evaluative Sciences, Toronto, ON, Canada; Institute of Health Policy, Management & Evaluation, University of Toronto, Toronto, ON, Canada. Electronic address: natalie.coburn@sunnybrook.ca.
University of Toronto · CAInstitute for Clinical Evaluative Sciences · CASunnybrook Health Science Centre · CAHealth Sciences Centre · CAMaimonides Medical Center · USSaint Barnabas Medical Center · USSunnybrook Research Institute

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundUsing a retrospective observational cohort approach, the overall survival (OS) following curative-intent resection of pancreatic adenocarcinoma (PC) was defined at the population level according to adjuvant treatment, and predictors of OS were identified.

methodsPatients undergoing resection of PC in the province of Ontario between 2005 and 2010 were identified using the provincial cancer registry, and linked to databases that include all treatments received and outcomes experienced in the province. Pathology reports were abstracted for staging and margin status. Patients were identified as having received chemotherapy (CT), chemoradiation therapy (CRT), or no adjuvant treatment (NAT). Kaplan-Meier survival analysis of patients surviving ≥ 6 months was performed, and predictors of OS identified by log-rank test. Cox multivariable analysis was used to define independent predictors of OS.

resultsAmong the 473 patients undergoing PC resection, the median survival was 17.8 months; for the 397 who survived ≥ 6 months following surgery, the 5-year OS for the CT, CRT, and NAT groups was 21%, 16%, and 17%, respectively (p = 0.584). Lymph node-negative patients demonstrated improved OS associated with chemotherapy on multivariable analysis (HR = 2.20, 95% CI = 1.25-3.83 for NAT vs. CT).

conclusionsFollowing PC resection, only patients with negative lymph nodes demonstrated improved OS associated with adjuvant chemotherapy.

Indexed as

PancreatectomyAgedAged, 80 and overCarcinoma, Pancreatic DuctalChemoradiotherapy, AdjuvantChemotherapy, AdjuvantFemaleHumansKaplan-Meier EstimateLymphatic MetastasisMaleMiddle AgedMultivariate AnalysisNeoplasm, ResidualNeoplasm StagingOntario

Identifiers

PMID27037203
PMCPMC4814617
OpenAlexW2259903214

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.