ArticleJournal of medical case reports2016
Acute cholestatic hepatitis induced by Epstein-Barr virus infection in an adult: a case report.
Article in Journal of medical case reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 33 citations in OpenAlex.
- Adolescent Epstein-Barr virus-associated cholestatic jaundice with porta hepatis/pancreatic head lymphadenopathy and transient CA 19-9 elevation: a case report.Frontiers in pediatrics · 2026Article
- When serology misleads: cross-reactivity in acute hepatitis.Archives of virology · 2025Review
- Article
- Non hepatotropic virus induced hepatitis - rising importance in a changing world.World journal of virology · 2025Review
- Article
- Article
- Cholestatic hepatitis in acute Epstein-Barr virus infection: A case report.Clinical case reports · 2024Article
- [Functional analysis of virus-specific CD4(+)T cells and CD8(+)T cells in patients with liver injury caused by Epstein-Barr virus infection].Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology · 2024Article
- Article
- Circulating Epstein-Barr virus DNA associated with hepatic impairment and its diagnostic and prognostic role in patients with gastric cancer.Frontiers in medicine · 2022Article
- Hepatocellular-Cholestatic Pattern of Liver Injury in a Patient With Infectious Mononucleosis.Cureus · 2021Article
- Article
- An insidious case of infectious mononucleosis presenting with acute appendicitis diagnosed postoperatively: a case report.Journal of surgical case reports · 2021Article
- Acute Liver Injury due to Severe Epstein-Barr Virus Infection.ACG case reports journal · 2020Article
- Acute hepatitis due to infectious mononucleosis.BMJ case reports · 2019Article
- Epstein-Barr virus and its association with disease - a review of relevance to general practice.BMC family practice · 2019Review
- Cholestasis induced liver pathology results in dysfunctional immune responses after arenavirus infection.Scientific reports · 2018Article
- A Case of Miller Fisher Syndrome, Thromboembolic Disease, and Angioedema: Association or Coincidence?The American journal of case reports · 2017Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAcute cholestatic hepatitis without features of infectious mononucleosis is a rare presentation of primary Epstein-Barr infection, with only several cases previously reported in the medical literature. Early investigation for Epstein-Barr virus in febrile patients with deranged liver function tests and no demonstrable biliary obstruction on imaging can expedite both diagnosis and treatment, thereby avoiding costly or invasive procedures such as liver biopsy. CASE PRESENTATION: A 59-year-old white woman of Anglo-Saxon descent presenting with a febrile illness was noted to have a cholestatic picture of deranged liver function tests. Over the following week a progressive obstructive jaundice developed, with no evidence of choledocholithiasis on ultrasound or magnetic resonance cholangiopancreatography. Specific immunoglobulin M antibodies against Epstein-Barr virus were detected in her serum and the diagnosis of Epstein-Barr hepatitis was confirmed by polymerase chain reaction testing. Supportive treatment was implemented and her liver function had normalized 3 months after presentation.
conclusionsEpstein-Barr virus is associated with a wide variety of clinical manifestations and can present as cholestatic hepatitis with or without features of infectious mononucleosis. While the diagnosis is often suggested by serological testing, Epstein-Barr virus polymerase chain reaction is a new non-invasive laboratory study that can help identify infection in cases where the clinical presentation is atypical.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.