Evidence map›Paper›PMID 27036918›Full record

GuidelineJournal of the American College of Cardiology2016

2016 ACC/AHA Guideline Focused Update on Duration of Dual Antiplatelet Therapy in Patients With Coronary Artery Disease: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines.

Glenn N Levine, Eric R Bates, John A Bittl, Ralph G Brindis, Stephan D Fihn, Lee A Fleisher, Christopher B Granger, Richard A Lange, Michael J Mack, Laura Mauri and 7 more

5 registry-linked trialsAbstract readPractice Guideline
PubMed Publisher
In one paragraph

Guideline in Journal of the American College of Cardiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 5 registered trials, which are not on this map. Cited by 471 papers, 22 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
471citing papers in PubMed, 22 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03378934 phase4recruitingnot on this mapstarted 2018, after this paper: background citation

A Single-center, Randomized, Open-label, Controlled, Dose-escalating, Parallel-group Study to Assess the Anti-platelet Effect of Berberine in Patients Receiving Aspirin and Clopidogrel After Percutaneous Coronary Intervention

TypeinterventionalSponsorPeking Union Medical College HospitalRan2018 to 2026Enrolled64ConditionsCoronary Artery Disease, Percutaneous Coronary InterventionArmsBerberine, Standard treatment, Aspirin, Clopidogrel
NCT04057300 phase4completednot on this mapstarted 2018, after this paper: background citation

Ticagrelor Compared to Clopidogrel in Acute Coronary Syndromes - the TC4 Comparative Effectiveness Study

TypeinterventionalSponsorMcGill University Health Centre/Research Institute of the McGill University Health CentreRan2018 to 2023Enrolled1,038ConditionsAcute Coronary SyndromeArmsTicagrelor 90mg, Clopidogrel 75mg, acetylsalicylic acid (ASA) 81mg
NCT04135989 phase4unknown statusnot on this mapstarted 2020, after this paper: background citation

Randomized 2x2 Factorial Trial Comparing the Cre8 Amphilimus-sirolimus Eluting Stent vs. the Synergy Everolimus-eluting Stent and a Personalized vs. Standard Duration of Dual Antiplatelet Therapy in All-comers Patients Undergoing Percutaneous Coronary Intervention

TypeinterventionalSponsorFederico II UniversityRan2020 to 2024Enrolled2,106ConditionsCoronary Artery Disease, Acute Coronary Syndrome, Chronic Coronary Syndrome, Myocardial InfarctionArmsPercutaneous coronary intervention with implantation of amphilimus-eluting stents for coronary artery disease., Percutaneous coronary intervention with implantation of everolimus-eluting stents for coronary artery disease., Personalized DAPT duration, Standard DAPT duration
NCT06993415 recruitingnot on this mapstarted 2025, after this paper: background citation

Optimize Risk Prediction After Myocardial Infarction Through Artificial Intelligence and Multidimensional Evaluation: The ORACLE Study

TypeobservationalSponsorFundación Pública Andaluza para la Investigación de Málaga en Biomedicina y SaludRan2025 to 2028Enrolled750ConditionsMyocardial Infarction (MI)Armsdata collection
NCT07125651 not yet recruitingnot on this mapstarted 2025, after this paper: background citation

Prevalence of Gastrointestinal Bleeding in Ischemic Heart Disease Patients Undergoing Single Compared to Dual Antiplatelet Treatment

TypeobservationalSponsorAssiut UniversityRan2025 to 2026Enrolled112ConditionsGastro Intestinal Bleeding, Ischaemic Heart Diseases, Antiplatelet Drugs, Antiplatelet Drug-related Gastrointestinal Injury
3 · Its place in the literature

Who cites it

471 citing papers in PubMed, 22 syntheses or guidelines pooled it.

  1. Prasugrel in the management of acute coronary syndromes: a systematic review.Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences · 2026
    Pooled it
  2. Indobufen Dual Antiplatelet Therapy (DAPT) Versus Aspirin Dual Antiplatelet Therapy (DAPT) After Percutaneous Coronary Intervention (PCI): A Systematic Review and Meta-Analysis.Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions · 2026
    Pooled it
  3. One-Year Outcomes of Short-Term Dual Antiplatelet Therapy Following Percutaneous Coronary Intervention With Drug-Eluting Stents: A Meta-Analysis of Randomized Clinical Trials.Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions · 2025
    Pooled it
  4. Pooled it
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  6. Guideline
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  8. Guideline
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  10. P2YReviews in cardiovascular medicine · 2023
    Pooled it
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  17. Guideline
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411 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

17 authors.

Glenn N Levine
Eric R Bates
John A Bittl
Ralph G Brindis
Stephan D Fihn
Lee A Fleisher
Christopher B Granger
Richard A Lange
Michael J Mack
Laura Mauri
Roxana Mehran
Debabrata Mukherjee
L Kristin Newby
Patrick T O'Gara
Marc S Sabatine
Peter K Smith
Sidney C Smith

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

AlgorithmsAspirinCoronary Artery DiseaseHumansPlatelet Aggregation InhibitorsPurinergic P2Y Receptor AntagonistsTime FactorsAspirinPlatelet Aggregation InhibitorsPurinergic P2Y Receptor AntagonistsACC/AHA Clinical Practice Guidelineacute coronary syndromeaspirincoronary artery diseasecoronary stentsdual antiplatelet therapy (DAPT)focused updateP2Y(12) inhibitorstable ischemic heart disease

Identifiers

PMID27036918

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.