ArticleSocial cognitive and affective neuroscience2016
An oxytocin receptor polymorphism predicts amygdala reactivity and antisocial behavior in men.
Article in Social cognitive and affective neuroscience, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 45 citations in OpenAlex.
- Oxytocin receptor gene variations and socio-emotional effects of MDMA: A pooled analysis of controlled studies in healthy subjects.PloS one · 2018Trial
- Why Do They Do It? The Psychology Behind Antisocial Behavior in Children and Adolescents.Pediatric reports · 2025Review
- Functional significance of some common oxytocin receptor SNPs involved in complex human traits.BMC molecular and cell biology · 2025Article
- Article
- Challenges Faced by Behavioral Genetic Studies: Researchers Perspective from the MENA Region.Current genomics · 2021Article
- Accumbofrontal tract integrity is related to early life adversity and feedback learning.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2021Article
- Imaging-genetics of sex differences in ASD: distinct effects of OXTR variants on brain connectivity.Translational psychiatry · 2020Article
- How should we understand the absence of sex differences in the genetic and environmental origins of antisocial behavior?Psychological medicine · 2019Review
- Accelerated alcohol use across adolescence predicts early adult symptoms of alcohol use disorder via reward-related neural function.Psychological medicine · 2019Article
- Oxytocin Receptor Gene (OXTR) and Deviant Peer Affiliation: A Gene-Environment Interaction in Adolescent Antisocial Behavior.Journal of youth and adolescence · 2019Article
- Associations between Oxytocin Receptor (OXTR) Genotype and Elementary School Children's Likability, Dis-likability and Friendship among Classroom Peers: A Longitudinal Study.Journal of youth and adolescence · 2018Article
- Replication in Imaging Genetics: The Case of Threat-Related Amygdala Reactivity.Biological psychiatry · 2018Review
- Evidence for Association Between OXTR Gene and ASD Clinical Phenotypes.Journal of molecular neuroscience : MN · 2018Article
- Oxytocin and vasopressin neural networks: Implications for social behavioral diversity and translational neuroscience.Neuroscience and biobehavioral reviews · 2017Review
- How Oxytocin Receptor (OXTR) Single Nucleotide Polymorphisms Act on Prosociality: The Mediation Role of Moral Evaluation.Frontiers in psychology · 2017Article
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
Variability in oxytocin (OXT) signaling is associated with individual differences in sex-specific social behavior across species. The effects of OXT signaling on social behavior are, in part, mediated through its modulation of amygdala function. Here, we use imaging genetics to examine sex-specific effects of three single-nucleotide polymorphisms in the human oxytocin receptor gene (OXTR; rs1042778, rs53576 and rs2254298) on threat-related amygdala reactivity and social behavior in 406 Caucasians. Analyses revealed that among men but not women, OXTR rs1042778 TT genotype was associated with increased right amygdala reactivity to angry facial expressions, which was uniquely related to higher levels of antisocial behavior among men. Moderated meditation analysis suggested a trending indirect effect of OXTR rs1042778 TT genotype on higher antisocial behavior via increased right amygdala reactivity to angry facial expressions in men. Our results provide evidence linking genetic variation in OXT signaling to individual differences in amygdala function. The results further suggest that these pathways may be uniquely important in shaping antisocial behavior in men.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.