ArticleeLife2016
Structural development and dorsoventral maturation of the medial entorhinal cortex.
Article in eLife, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 37 citations in OpenAlex.
- Integrative analysis of single-cell multi-omics reveals heterogeneity in piriform cortex principal neurons and their selective vulnerability in Alzheimer's disease.Clinical and translational medicine · 2026Article
- NMDA receptor antagonist induced c-Fos expression in the medial entorhinal cortex during postnatal development.Frontiers in neural circuits · 2025Article
- Selective vulnerability of stellate cells to gut dysbiosis: neuroanatomical changes in the medial entorhinal cortex.Frontiers in neuroanatomy · 2025Article
- A 3D mixed reality visualization of network topology and activity results in better dyadic cyber team communication and cyber situational awareness.Frontiers in big data · 2023Article
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- Local Microcircuitry of PaS Shows Distinct and Common Features of Excitatory and Inhibitory Connectivity.Cerebral cortex (New York, N.Y. : 1991) · 2021Article
- Molecular Characterization of Superficial Layers of the Presubiculum During Development.Frontiers in neuroanatomy · 2021Article
- Developmental Patterning and Neurogenetic Gradients ofFrontiers in neuroanatomy · 2021Article
- Development of the Entorhinal Cortex Occurs via Parallel Lamination During Neurogenesis.Frontiers in neuroanatomy · 2021Article
- Species-specific differences in synaptic transmission and plasticity.Scientific reports · 2020Article
- Article
- Cell numbers, distribution, shape, and regional variation throughout the murine hippocampal formation from the adult brain Allen Reference Atlas.Brain structure & function · 2019Article
- Postnatal Development of Functional Projections from Parasubiculum and Presubiculum to Medial Entorhinal Cortex in the Rat.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- Moderate prenatal alcohol exposure impairs performance by adult male rats in an object-place paired-associate task.Behavioural brain research · 2019Article
- Visualization of Cortical Modules in Flattened Mammalian Cortices.Journal of visualized experiments : JoVE · 2018Article
- Complementary Modular Microcircuits of the Rat Medial Entorhinal Cortex.Frontiers in systems neuroscience · 2017Article
- Cell Type-Specific Differences in Spike Timing and Spike Shape in the Rat Parasubiculum and Superficial Medial Entorhinal Cortex.Cell reports · 2016Article
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Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We investigated the structural development of superficial-layers of medial entorhinal cortex and parasubiculum in rats. The grid-layout and cholinergic-innervation of calbindin-positive pyramidal-cells in layer-2 emerged around birth while reelin-positive stellate-cells were scattered throughout development. Layer-3 and parasubiculum neurons had a transient calbindin-expression, which declined with age. Early postnatally, layer-2 pyramidal but not stellate-cells co-localized with doublecortin - a marker of immature neurons - suggesting delayed functional-maturation of pyramidal-cells. Three observations indicated a dorsal-to-ventral maturation of entorhinal cortex and parasubiculum: (i) calbindin-expression in layer-3 neurons decreased progressively from dorsal-to-ventral, (ii) doublecortin in layer-2 calbindin-positive-patches disappeared dorsally before ventrally, and (iii) wolframin-expression emerged earlier in dorsal than ventral parasubiculum. The early appearance of calbindin-pyramidal-grid-organization in layer-2 suggests that this pattern is instructed by genetic information rather than experience. Superficial-layer-microcircuits mature earlier in dorsal entorhinal cortex, where small spatial-scales are represented. Maturation of ventral-entorhinal-microcircuits - representing larger spatial-scales - follows later around the onset of exploratory behavior.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.