ArticleProceedings of the National Academy of Sciences of the United States of America2016
Modeling and analysis of collective cell migration in an in vivo three-dimensional environment.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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Who cites it
38 citing papers in PubMed.
- Mechanisms Underlying the Initiation and Termination of Collective Cell Migration: Perspectives for Understanding Development and Cancer Metastasis.BioEssays : news and reviews in molecular, cellular and developmental biology · 2026Review
- Phase-field modeling of border cell cluster migration in Drosophila.PLoS computational biology · 2026Article
- Article
- The influence of cell phenotype on collective cell invasion into the extracellular matrix.Bulletin of mathematical biology · 2025Article
- Dynamic forces drive cell and organ morphology changes during embryonic development.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Chemotaxis of Drosophila border cells is modulated by tissue geometry through dispersion of chemoattractants.iScience · 2025Article
- Model supports asymmetric regulation across the intercellular junction for collective cell polarization.PLoS computational biology · 2024Article
- Thermotaxis in an apolar, non-neuronal animal.Journal of the Royal Society, Interface · 2023Article
- A computational framework for testing hypotheses of the minimal mechanical requirements for cell aggregation using early annual killifish embryogenesis as a model.Frontiers in cell and developmental biology · 2023Article
- Collective chemotaxis in a Voronoi model for confluent clusters.Biophysical journal · 2022Article
- Cell-Taxi: Mesenchymal Cells Carry and Transport Clusters of Cancer Cells.Small (Weinheim an der Bergstrasse, Germany) · 2022Article
- Polarized interfacial tension induces collective migration of cells, as a cluster, in a 3D tissue.Biophysical journal · 2022Article
- Viscoelasticity, Like Forces, Plays a Role in Mechanotransduction.Frontiers in cell and developmental biology · 2022Review
- 3D viscoelastic drag forces contribute to cell shape changes during organogenesis in the zebrafish embryo.Cells & development · 2021Article
- Enhanced persistence and collective migration in cooperatively aligning cell clusters.Biophysical journal · 2021Article
- Bridging from single to collective cell migration: A review of models and links to experiments.PLoS computational biology · 2020Review
- Multi-scale analysis and modelling of collective migration in biological systems.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2020Article
- Fascin regulates protrusions and delamination to mediate invasive, collective cell migration in vivo.Developmental dynamics : an official publication of the American Association of Anatomists · 2020Article
- Prostaglandins regulate invasive, collective border cell migration.Molecular biology of the cell · 2020Article
- Active diffusion in oocytes nonspecifically centers large objects during prophase I and meiosis I.The Journal of cell biology · 2020Article
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Authors and funding
6 authors.
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Abstract
A long-standing question in collective cell migration has been what might be the relative advantage of forming a cluster over migrating individually. Does an increase in the size of a collectively migrating group of cells enable them to sample the chemical gradient over a greater distance because the difference between front and rear of a cluster would be greater than for single cells? We combined theoretical modeling with experiments to study collective migration of the border cells in-between nurse cells in the Drosophila egg chamber. We discovered that cluster size is positively correlated with migration speed, up to a particular point above which speed plummets. This may be due to the effect of viscous drag from surrounding nurse cells together with confinement of all of the cells within a stiff extracellular matrix. The model predicts no relationship between cluster size and velocity for cells moving on a flat surface, in contrast to movement within a 3D environment. Our analyses also suggest that the overall chemoattractant profile in the egg chamber is likely to be exponential, with the highest concentration in the oocyte. These findings provide insights into collective chemotaxis by combining theoretical modeling with experimentation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.