ArticleProceedings of the National Academy of Sciences of the United States of America2016
Discrete gene replication events drive coupling between the cell cycle and circadian clocks.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed.
- Checkpoint kinases regulate the circadian clock after DNA damage by influencing chromatin dynamics.Nucleic acids research · 2025Article
- Origin of the clock inFrontiers in molecular biosciences · 2025Review
- The clock in growing hyphae and their synchronization in Neurospora crassa.Communications biology · 2024Article
- E-box binding transcription factors in cancer.Frontiers in oncology · 2023Review
- Evolution of Complex Regulation for Cell-Cycle Control.Genome biology and evolution · 2022Article
- Review
- Article
- Learning the non-equilibrium dynamics of Brownian movies.Nature communications · 2020Article
- The Lineage Before Time: Circadian and Nonclassical Clock Influences on Development.Annual review of cell and developmental biology · 2020Review
- High intrinsic hydrolytic activity of cyanobacterial RNA polymerase compensates for the absence of transcription proofreading factors.Nucleic acids research · 2020Article
- Low-dimensional Dynamics of Two Coupled Biological Oscillators.Nature physics · 2019Article
- The bacterial cell cycle, chromosome inheritance and cell growth.Nature reviews. Microbiology · 2019Review
- Coordination of Polyploid Chromosome Replication with Cell Size and Growth in a Cyanobacterium.mBio · 2019Article
- The positive circadian regulators CLOCK and BMAL1 control G2/M cell cycle transition through Cyclin B1.Cell cycle (Georgetown, Tex.) · 2019Article
- Computational modelling unravels the precise clockwork of cyanobacteria.Interface focus · 2018Review
- Cell size control driven by the circadian clock and environment in cyanobacteria.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Division rate, cell size and proteome allocation: impact on gene expression noise and implications for the dynamics of genetic circuits.Royal Society open science · 2018Article
- Ensemble methods for stochastic networks with special reference to the biological clock of Neurospora crassa.PloS one · 2018Article
- Modeling-Based Investigation of the Effect of Noise in Cellular Systems.Frontiers in molecular biosciences · 2018Review
- A thermodynamically consistent model of the post-translational Kai circadian clock.PLoS computational biology · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Many organisms possess both a cell cycle to control DNA replication and a circadian clock to anticipate changes between day and night. In some cases, these two rhythmic systems are known to be coupled by specific, cross-regulatory interactions. Here, we use mathematical modeling to show that, additionally, the cell cycle generically influences circadian clocks in a nonspecific fashion: The regular, discrete jumps in gene-copy number arising from DNA replication during the cell cycle cause a periodic driving of the circadian clock, which can dramatically alter its behavior and impair its function. A clock built on negative transcriptional feedback either phase-locks to the cell cycle, so that the clock period tracks the cell division time, or exhibits erratic behavior. We argue that the cyanobacterium Synechococcus elongatus has evolved two features that protect its clock from such disturbances, both of which are needed to fully insulate it from the cell cycle and give it its observed robustness: a phosphorylation-based protein modification oscillator, together with its accompanying push-pull read-out circuit that responds primarily to the ratios of different phosphoform concentrations, makes the clock less susceptible to perturbations in protein synthesis; the presence of multiple, asynchronously replicating copies of the same chromosome diminishes the effect of replicating any single copy of a gene.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.