ArticleInternational journal of oncology2016
Potential screening and early diagnosis method for cancer: Tongue diagnosis.
Article in International journal of oncology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers, 2 of them syntheses that pooled it.
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Who cites it
50 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Relationship between oral microbiota and colorectal cancer: A systematic review.Journal of periodontal research · 2024Pooled it
- The Human Microbiome in Relation to Cancer Risk: A Systematic Review of Epidemiologic Studies.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2020Pooled it
- Human salivary microbiome as a potential non-invasive biomarker for early-onset colorectal cancer screening: a prospective study.BMC microbiology · 2026Article
- Exploring traditional Chinese medicine tongue diagnosis in potential cancer identification: A scoping review.Integrative medicine research · 2026Review
- Fusion color space analysis of tongue image characteristics in different stages of metastatic colorectal cancer and three-class model construction.Frontiers in physiology · 2026Article
- Integration of tongue image features and tongue coating microbiome for differentiating dampness patterns in MASLD.Frontiers in endocrinology · 2026Article
- The association between tongue features and tongue coating microbiota and gastrointestinal cancer: a systematic review and meta-analysis.Journal of oral microbiology · 2026Review
- Objective pulse wave amplitude as a potential systemic correlate in childhood myopia: a digital TCM-based study.Frontiers in medicine · 2026Article
- Computerized tongue image analysis for non-invasive disease screening: a review.Chinese medicine · 2025Review
- Beyond biomarkers: An integrated traditional Chinese medicine-machine learning approach predicts hepatic steatosis in high metabolic risk populations.World journal of gastroenterology · 2025Article
- An improved lightweight tongue segmentation model with self-attention parallel network and progressive upsampling.Scientific reports · 2025Article
- Clinical study of intelligent tongue diagnosis and oral microbiome for classifying TCM syndromes in MASLD.Chinese medicine · 2025Article
- Oral microbiota signature predicts the prognosis of colorectal carcinoma.NPJ biofilms and microbiomes · 2025Article
- Reliability of noninvasive hyperspectral tongue diagnosis for menstrual diseases using machine learning method.Scientific reports · 2025Article
- Cross-population tongue image features and tongue coating microbiome changes in the evolution of colorectal cancer.Frontiers in microbiology · 2025Article
- Diagnosis of non-puerperal mastitis based on "whole tongue" features: non-invasive biomarker mining and diagnostic model construction.Frontiers in cellular and infection microbiology · 2025Article
- Tongue coating microbiota-based machine learning for diagnosing digestive system tumours.Journal of oral microbiology · 2025Article
- Temporal changes in tongue color during immune checkpoint inhibitor therapy in patients with non-small-cell lung cancer: a prospective observational study using digital tongue diagnosis.Oncology reviews · 2025Article
- Objective Analysis of Traditional Chinese Medicine Syndrome Differentiation of Patients With Diabetes and Prediabetes: Protocol for a Nonrandomized, Exploratory, Observational Case-Control Study Using Digitalized Traditional Chinese Medicine Diagnostic Tools.JMIR research protocols · 2024Observational
- A Novel Tongue Coating Segmentation Method Based on Improved TransUNet.Sensors (Basel, Switzerland) · 2024Article
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Tongue diagnosis, as a unique method of traditional Chinese medicine (TCM), was used to discriminate physiological functions and pathological conditions by observing the changes of the tongue and tongue coating. The aims of the present study were to explore a potential screening and early diagnosis method of cancer through evaluating the differences of the images of tongue and tongue coating and the microbiome on the tongue coating. The DS01-B tongue diagnostic information acquisition system was used to photograph and analyze the tongue and tongue coating. The next-generation sequencing technology was used to determine the V2-V4 hypervariable regions of 16S rDNA to investigate the microbiome on the tongue coating. Bioinformatics and statistical methods were used to analyze the microbial community structure and diversity. Comparing with the healthy people, the number of mirror-like tongue, thick tongue coating and the moisture of tongue were increased in cancers. The dominant color of the tongue in the healthy people was reddish while it was purple in the cancers. The relative abundance of Neisseria, Haemophilus, Fusobacterium and Porphyromonas in the healthy people were higher than that in the cancers. We also found 6 kinds of special microorganisms at species level in cancers. The study suggested that tongue diagnosis may provide potential screening and early diagnosis method for cancer.
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