Observational studyCritical care medicine2016
Age, PaO2/FIO2, and Plateau Pressure Score: A Proposal for a Simple Outcome Score in Patients With the Acute Respiratory Distress Syndrome.
Observational study in Critical care medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
49 citing papers in PubMed, 1 synthesis or guideline pooled it, 99 citations in OpenAlex.
- Predictive Value of the PaOInternal medicine (Tokyo, Japan) · 2025Pooled it
- Development and validation of a clinical risk model to predict the hospital mortality in ventilated patients with acute respiratory distress syndrome: a population-based study.BMC pulmonary medicine · 2022Trial
- Validation of age, PaORespiratory research · 2020Trial
- Characteristics of neonatal necrotizing enterocolitis in relation to the presence or absence of patent ductus arteriosus.BMC pregnancy and childbirth · 2025Article
- Clinical characteristics and prognosis of patients treated as invasive pulmonary aspergillosis outside of severe immunosuppression.Scientific reports · 2025Article
- Lung uptake of two SPECT markers identifies sensitivity to hyperoxia-induced acute respiratory distress syndrome in rats.Frontiers in physiology · 2025Article
- Serum β2-microglobulin as an independent risk factor for mortality in patients with acute respiratory distress syndrome caused by bacterial infection.Scientific reports · 2024Article
- Clinical relevance of timing of assessment of ICU mortality in patients with moderate-to-severe Acute Respiratory Distress Syndrome.Scientific reports · 2023Article
- In vivo molecular imaging stratifies rats with different susceptibilities to hyperoxic acute lung injury.American journal of physiology. Lung cellular and molecular physiology · 2022Article
- Development of a repeated-measures predictive model and clinical risk score for mortality in ventilated COVID-19 patients.Canadian journal of anaesthesia = Journal canadien d'anesthesie · 2022Article
- COVID-19 ARDS: Points to Be Considered in Mechanical Ventilation and Weaning.Journal of personalized medicine · 2021Review
- Extracorporeal Membrane Oxygenation for Secondary Organizing Pneumonia after Severe SARS-CoV-2 Infection: A Case Report.Medicina (Kaunas, Lithuania) · 2021Article
- Predicting Duration of Mechanical Ventilation in Acute Respiratory Distress Syndrome Using Supervised Machine Learning.Journal of clinical medicine · 2021Article
- P/FP ratio: incorporation of PEEP into the PaOAnnals of intensive care · 2021Article
- Cyclophosphamide for interstitial lung disease-associated acute respiratory failure: mortality, clinical response and radiological characteristics.BMC pulmonary medicine · 2021Article
- Ten golden rules for individualized mechanical ventilation in acute respiratory distress syndrome.Journal of intensive medicine · 2021Review
- Acute Respiratory Distress Syndrome in the Elderly.Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine · 2021Article
- Mortality prediction for patients with acute respiratory distress syndrome based on machine learning: a population-based study.Annals of translational medicine · 2021Article
- Admission High-Sensitive Cardiac Troponin T Level Increase Is Independently Associated with Higher Mortality in Critically Ill Patients with COVID-19: A Multicenter Study.Journal of clinical medicine · 2021Article
- The role of extracorporeal membrane oxygenation in critically ill patients with COVID-19: a narrative review.BMC pulmonary medicine · 2021Review
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Authors and funding
18 authors at 9 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesAlthough there is general agreement on the characteristic features of the acute respiratory distress syndrome, we lack a scoring system that predicts acute respiratory distress syndrome outcome with high probability. Our objective was to develop an outcome score that clinicians could easily calculate at the bedside to predict the risk of death of acute respiratory distress syndrome patients 24 hours after diagnosis.
designA prospective, multicenter, observational, descriptive, and validation study.
settingA network of multidisciplinary ICUs. PATIENTS: Six-hundred patients meeting Berlin criteria for moderate and severe acute respiratory distress syndrome enrolled in two independent cohorts treated with lung-protective ventilation.
interventionsNone. MEASUREMENTS AND MAIN
resultsUsing individual demographic, pulmonary, and systemic data at 24 hours after acute respiratory distress syndrome diagnosis, we derived our prediction score in 300 acute respiratory distress syndrome patients based on stratification of variable values into tertiles, and validated in an independent cohort of 300 acute respiratory distress syndrome patients. Primary outcome was in-hospital mortality. We found that a 9-point score based on patient's age, PaO2/FIO2 ratio, and plateau pressure at 24 hours after acute respiratory distress syndrome diagnosis was associated with death. Patients with a score greater than 7 had a mortality of 83.3% (relative risk, 5.7; 95% CI, 3.0-11.0), whereas patients with scores less than 5 had a mortality of 14.5% (p < 0.0000001). We confirmed the predictive validity of the score in a validation cohort.
conclusionsA simple 9-point score based on the values of age, PaO2/FIO2 ratio, and plateau pressure calculated at 24 hours on protective ventilation after acute respiratory distress syndrome diagnosis could be used in real time for rating prognosis of acute respiratory distress syndrome patients with high probability.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.