ReviewEpigenomics2016
DNA methylation as a potential mediator of environmental risks in the development of childhood acute lymphoblastic leukemia.
Review in Epigenomics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- DNA methylation in monozygotic twins discordant for acute lymphoblastic leukemia: a case report and systematic review.Clinical epigenetics · 2025Pooled it
- Environmental Epigenetic Changes, as Risk Factors for the Development of Diseases in Children: A Systematic Review.Annals of global health · 2018Pooled it
- The impact of periconceptional folate on the DNA methylome of acute lymphoblastic leukemia.Leukemia · 2026Article
- Speeding up interval estimation for R2-based mediation effect of high-dimensional mediators via cross-fitting.Biostatistics (Oxford, England) · 2025Article
- DNA methylation profiles and cancer in children conceived after assisted reproductive technology.Clinical epigenetics · 2025Article
- Speeding up interval estimation forbioRxiv : the preprint server for biology · 2024Article
- Novel epigenetic biomarkers for hematopoietic cancer found in twins.Acta oncologica (Stockholm, Sweden) · 2024Article
- Assessment of the Prevalence of Infections in Pediatric Patients With Acute Lymphoblastic Leukemia.Cureus · 2023Review
- 2'-Hydroxy-4',5'-dimethoxyacetophenone Exhibit Collagenase, Aldose Reductase Inhibition, and Anticancer Activity Against Human Leukemic Cells: An In Vitro, and In Silico Study.Molecular biotechnology · 2023Article
- Toxicoepigenetics and Environmental Health: Challenges and Opportunities.Chemical research in toxicology · 2022Review
- Exploring the genetic and epigenetic origins of juvenile myelomonocytic leukemia using newborn screening samples.Leukemia · 2022Article
- Gene-based mediation analysis in epigenetic studies.Briefings in bioinformatics · 2021Article
- Risk Factors for Childhood Leukemia: Radiation and Beyond.Frontiers in public health · 2021Review
- DNA methylation mediates the effect of cocaine use on HIV severity.Clinical epigenetics · 2020Article
- Pathogenesis of pediatric B-cell acute lymphoblastic leukemia: Molecular pathways and disease treatments.Oncology letters · 2020Review
- Nanopore Sequencing in Blood Diseases: A Wide Range of Opportunities.Frontiers in genetics · 2020Review
- Exploring a potential mechanistic role of DNA methylation in the relationship between in utero and post-natal environmental exposures and risk of childhood acute lymphoblastic leukaemia.International journal of cancer · 2019Article
- Methyl-Donor and Cofactor Nutrient Intakes in the First 2-3 Years and Global DNA Methylation at Age 4: A Prospective Cohort Study.Nutrients · 2018Article
- Misclassified exposure in epigenetic mediation analyses. Does DNA methylation mediate effects of smoking on birthweight?Epigenomics · 2017Article
- Precision medicine and health disparities: The case of pediatric acute lymphoblastic leukemia.Nursing outlookArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
5-year survival rate for childhood acute lymphoblastic leukemia (ALL) has risen to approximately 90%, yet the causal disease pathway is still poorly understood. Evidence suggests multiple 'hits' are required for disease progression; an initial genetic abnormality followed by additional secondary 'hits'. It is plausible that environmental influences may trigger these secondary hits, and with the peak incidence of diagnosis between 2 and 5 years of age, early life exposures are likely to be key. DNA methylation can be modified by many environmental exposures and is dramatically altered in cancers, including childhood ALL. Here we explore the potential that DNA methylation may be involved in the causal pathway toward disease by acting as a mediator between established environmental factors and childhood ALL development.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.