Evidence map›Paper›PMID 27035164›Full record

ReviewJournal of neurosurgery2017

Convection-enhanced delivery in glioblastoma: a review of preclinical and clinical studies.

Arman Jahangiri, Aaron T Chin, Patrick M Flanigan, Rebecca Chen, Krystof Bankiewicz, Manish K Aghi

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of neurosurgery, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 126 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
126citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

126 citing papers in PubMed, 4 syntheses or guidelines pooled it.

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  10. Digital Twin Technology In Radiology.Journal of imaging informatics in medicine · 2026
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66 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Arman JahangiriDepartment of Neurological Surgery, University of California at San Francisco, San Francisco, California.
Aaron T ChinDepartment of Neurological Surgery, University of California at San Francisco, San Francisco, California.
Patrick M FlaniganDepartment of Neurological Surgery, University of California at San Francisco, San Francisco, California.
Rebecca ChenDepartment of Neurological Surgery, University of California at San Francisco, San Francisco, California.
Krystof BankiewiczDepartment of Neurological Surgery, University of California at San Francisco, San Francisco, California.
Manish K AghiDepartment of Neurological Surgery, University of California at San Francisco, San Francisco, California.

Funding

Tumor cell and microenvironment changes causing antiangiogenic therapy resistanceR01NS079697 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI AGHI, MANISH · 2013 to 2021
$3.2M
NINDS NIH HHS R01 NS079697
6 · The paper itself

Abstract

Glioblastoma is the most common malignant brain tumor, and it carries an extremely poor prognosis. Attempts to develop targeted therapies have been hindered because the blood-brain barrier prevents many drugs from reaching tumors cells. Furthermore, systemic toxicity of drugs often limits their therapeutic potential. A number of alternative methods of delivery have been developed, one of which is convection-enhanced delivery (CED), the focus of this review. The authors describe CED as a therapeutic measure and review preclinical studies and the most prominent clinical trials of CED in the treatment of glioblastoma. The utilization of this technique for the delivery of a variety of agents is covered, and its shortcomings and challenges are discussed in detail.

Indexed as

AnimalsBrain NeoplasmsConvectionDrug Delivery SystemsGlioblastomaHumansBBB = blood-brain barrierblood-brain barrierCED = convection-enhanced deliveryconvection enhanced deliveryGDL = gadoteridol-loaded liposomesglioblastomaHSV-TK = herpes simplex virus–thymidine kinaseIL-4 = interleukin-4oncologyOS = overall survivalPFS = progression-free survivalTF = transferrinTMZ = temozolomideTRAIL = tumor necrosis factor–related apoptosis-inducing ligand

Identifiers

PMID27035164
PMCPMC5571827

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.