Evidence map›Paper›PMID 27035126›Full record

ArticleMolecular medicine reports2016

Correlation between insulin‑like growth factor binding protein 3 and metastasis‑associated gene 1 protein in esophageal squamous cell carcinoma.

Haiping Yang, Lijuan Xu, Haili Qian, Xinqiang Niu, Dan Zhao, Zhilong Zhao, Jun Wu, Junfeng Liu, Yanyu Wang

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular medicine reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 3 pooled it
1.0field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 3 syntheses or guidelines pooled it, 7 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 6 institutions in 1 country.

Haiping YangDepartment of Thoracic and Cardiovascular Surgery, Beijing Luhe Hospital Affiliated to Capital Medical University, Beijing 101100, P.R. China.
Lijuan XuDepartment of Thoracic and Cardiovascular Surgery, Beijing Luhe Hospital Affiliated to Capital Medical University, Beijing 101100, P.R. China.
Haili QianState Key Laboratory of Molecular Oncology, Cancer Hospital/Institute, Chinese Academy of Medical Sciences, Beijing 100021, P.R. China.
Xinqiang NiuDepartment of Thoracic Surgery, Cixian People's Hospital, Handan, Hebei 056500, P.R. China.
Dan ZhaoDepartment of Pathology, Beijing Chest Hospital of Capital Medical University, Beijing 101100, P.R. China.
Zhilong ZhaoDepartment of Cardiothoracics, Zhongshan Hospital, Dalian University, Dalian, Liaoning 116001, P.R. China.
Jun WuDepartment of Thoracic and Cardiovascular Surgery, Beijing Luhe Hospital Affiliated to Capital Medical University, Beijing 101100, P.R. China.
Junfeng LiuDepartment of Thoracic Surgery, Fourth Hospital, Hebei Medical University, Shijiazhuang, Hebei 050011, P.R. China.
Yanyu WangDepartment of Thoracic and Cardiovascular Surgery, Beijing Luhe Hospital Affiliated to Capital Medical University, Beijing 101100, P.R. China.
Beijing Luhe Hospital Affiliated to Capital Medical University · CNAffiliated Zhongshan Hospital of Dalian University · CNCapital Medical University · CNChinese Academy of Medical Sciences & Peking Union Medical College · CNCixian People's Hospital · CNHebei Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The present study aimed to investigate the correlation between insulin‑like growth factor binding protein 3 (IGFBP‑3) and metastasis‑associated gene 1 (MTA1) protein, and the clinicopathological features and prognosis of esophageal squamous cell carcinoma (ESCC). Patients with ESCC who underwent surgical resection were enrolled in the current study, ESCC tissues and adjacent normal tissues (control) were obtained from 197 patients. The protein expression levels of IGFBP‑3 and MTA1 were detected using immunohistochemistry. The results demonstrated that the expression of IGFBP‑3 in ESCC tissues was significantly lower than in the adjacent normal tissues (27.4 vs. 40.6%; P<0.05), and was negatively correlated with smoking status, degree of tumor differentiation and lymph node metastasis (P<0.05). The expression of MTA1 protein in ESCC tissues was significantly higher than that of the adjacent tissues (42.1 vs. 11.2%; P<0.05), and was positively correlated with the tumor size, extent of tumor invasion and lymph node metastasis (P<0.05). No association was identified between the protein expression levels of IGFBP‑3 and MTA1. The protein expression levels of IGFBP‑3 and MTA1 were not independent risk factors for ESCC prognosis; however, the degree of tumor invasion (P=0.02) and rate of lymph node metastasis (P=0.027) were. IGFBP‑3 inhibits the proliferation and metastasis of ESCC; however, MTA1 promotes the proliferation and metastasis of ESCC. There is no interaction between IGFBP‑3 and MTA1 in ESCC, and they are not independent risk factors for ESCC prognosis.

Indexed as

AdultAgedCarcinoma, Squamous CellEsophageal NeoplasmsEsophageal Squamous Cell CarcinomaFemaleHistone DeacetylasesHumansImmunohistochemistryInsulin-Like Growth Factor Binding Protein 3Lymphatic MetastasisMaleMiddle AgedNeoplasm ProteinsRepressor ProteinsTrans-ActivatorsHistone DeacetylasesIGFBP3 protein, humanInsulin-Like Growth Factor Binding Protein 3MTA1 protein, humanNeoplasm ProteinsRepressor ProteinsTrans-Activators

Identifiers

PMID27035126
PMCPMC4838119
OpenAlexW2305831567

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.