ArticlePsychiatry research. Neuroimaging2016
Amygdala volume is reduced in early course schizophrenia.
Article in Psychiatry research. Neuroimaging, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- The cross-site reproducibility of MRI morphometric phenotypes in psychiatric disorders.Nature neuroscience · 2026Article
- Subcortical brain abnormalities and cognitive function in individuals with psychosis and their unaffected relatives: A normative modeling approach.Schizophrenia research · 2025Article
- Links between trauma and psychosis (Review).Experimental and therapeutic medicine · 2023Review
- A significant, functional and replicable risk KTN1 variant block for schizophrenia.Scientific reports · 2023Article
- The Neural Correlates of the Social Perception Dysfunction in Schizophrenia: An fMRI Study.Neuropsychiatric disease and treatment · 2023Article
- Prevalence and Influence Factors for Non-Alcoholic Fatty Liver Disease in Long-Term Hospitalized Patients with Schizophrenia: A Cross-Sectional Retrospective Study.Neuropsychiatric disease and treatment · 2023Article
- Serotonin transporter functional polymorphisms potentially increase risk of schizophrenia separately and as a haplotype.Scientific reports · 2022Article
- A morphological study of schizophrenia with magnetic resonance imaging, advanced analytics, and machine learning.Frontiers in neuroscience · 2022Article
- Brain features of nearly drug-naïve female monozygotic twins with first-episode schizophrenia and the classification accuracy of brain feature patterns: A pilot study.Brain and behavior · 2021Article
- Study on the sub-regions volume of hippocampus and amygdala in schizophrenia.Quantitative imaging in medicine and surgery · 2019Article
- Subcortical structures and cognitive dysfunction in first episode schizophrenia.Psychiatry research. Neuroimaging · 2019Article
- Deletion of Dtnbp1 in mice impairs threat memory consolidation and is associated with enhanced inhibitory drive in the amygdala.Translational psychiatry · 2019Article
- Self-Awareness of Psychopathology and Brain Volume in Patients With First Episode Psychosis.Frontiers in psychiatry · 2019Article
- Structural connectivity of the amygdala in young adults with autism spectrum disorder.Human brain mapping · 2018Article
- RNA-seq analysis of amygdala tissue reveals characteristic expression profiles in schizophrenia.Translational psychiatry · 2017Article
- Differences in subcortical brain volumes among patients with schizophrenia and bipolar disorder and healthy controls.Journal of psychiatry & neuroscience : JPNArticle
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
Subcortical structural alterations have been implicated in the neuropathology of schizophrenia. Yet, the extent of anatomical alterations for subcortical structures across illness phases remains unknown. To assess this, magnetic resonance imaging (MRI) was used to examine volume differences of major subcortical structures: thalamus, nucleus accumbens, caudate, putamen, globus pallidus, amygdala and hippocampus. These differences were examined across four groups: (i) healthy comparison subjects (HCS, n=96); (ii) individuals at high risk (HR, n=21) for schizophrenia; (iii) early-course schizophrenia patients (EC-SCZ, n=28); and (iv) chronic schizophrenia patients (C-SCZ, n=20). Raw gray matter volumes and volumetric ratios (volume of specific structure/total gray matter volume) were extracted using automated segmentation tools. EC-SCZ group exhibited smaller bilateral amygdala volumetric ratios, compared to HCS and HR subjects. Findings did not change when corrected for age, level of education and medication use. Amygdala raw volumes did not differ among groups once adjusted for multiple comparisons, but the smaller amygdala volumetric ratio in EC-SCZ survived Bonferroni correction. Other structures were not different across the groups following Bonferroni correction. Smaller amygdala volumes during early illness course may reflect pathophysiologic changes specific to illness development, including disrupted salience processing and acute stress responses.
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