ArticlePsychiatry research. Neuroimaging2016
Brain metabolite levels in recently sober individuals with alcohol use disorder: Relation to drinking variables and relapse.
Article in Psychiatry research. Neuroimaging, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Brain metabolite alterations related to alcohol use: a meta-analysis of proton magnetic resonance spectroscopy studies.Molecular psychiatry · 2022Pooled it
- Effects of ibudilast on central and peripheral markers of inflammation in alcohol use disorder: A randomized clinical trial.Addiction biology · 2022Trial
- Frontal Brain N-Acetylaspartate at Treatment Entry is Related to Future World Health Organization Risk Drinking Levels in Individuals With Alcohol Use Disorder.Journal of studies on alcohol and drugs · 2025Article
- Imaging neuroinflammation in individuals with substance use disorders.The Journal of clinical investigation · 2024Review
- Anterior cingulate metabolite levels, memory, and inhibitory control in abstinent men and women with alcohol use disorder.Alcohol and alcoholism (Oxford, Oxfordshire) · 2023Article
- Alcohol Craving and Severity are Associated with Dorsal Anterior Cingulate Choline Levels in Individuals with an Alcohol Use Disorder.Alcohol and alcoholism (Oxford, Oxfordshire) · 2023Article
- Neuroimaging in alcohol use disorder: From mouse to man.Journal of neuroscience research · 2022Review
- Magnetic resonance imaging of neuroinflammation in chronic pain: a role for astrogliosis?Pain · 2020Article
- Brain Structure and Function in Recovery.Alcohol research : current reviews · 2020Review
- Basic Human Body Dimensions Relate to Alcohol Dependence and Predict Hospital Readmission.Journal of clinical medicine · 2019Article
- Cerebral Metabolites on the Descending Limb of Acute Alcohol: A Preliminary 1H MRS Study.Alcohol and alcoholism (Oxford, Oxfordshire) · 2019Article
- Prehabilitation in Alcohol Dependence as a Treatment Model for Sustainable Outcomes. A Narrative Review of Literature on the Risks Associated With Detoxification, From Animal Models to Human Translational Research.Frontiers in psychiatry · 2019Review
- An endophenotype approach to the genetics of alcohol dependence: a genome wide association study of fast beta EEG in families of African ancestry.Molecular psychiatry · 2017Article
- Concomitants of alcoholism: differential effects of thiamine deficiency, liver damage, and food deprivation on the rat brain in vivo.Psychopharmacology · 2016Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
Magnetic resonance spectroscopy (MRS) studies in alcohol use disorder (AUD) typically report lower levels of N-acetylaspartate (NAA) and choline-containing compounds (Cho) in several brain regions. Metabolite levels, however, are labile and can be affected by several competing factors, some related to drinking variables.. This in vivo MRS study included 20 recently sober (19.6±12.6 days) individuals with AUD and 15 controls. MRS was performed in single voxels placed in frontal white matter and thalamic regions using Constant-Time Point Resolved Spectroscopy (CT-PRESS) for absolute quantification of NAA, Cho, total creatine (tCr), and glutamate (Glu). A trend toward a thalamic NAA deficit in the total AUD group compared with controls was attributable to the subgroup of alcoholics who relapsed 3 or so months after scanning. In the total AUD group, frontal and thalamic NAA and Cho levels were lower with more recent drinking; frontal and thalamic Cho levels were also lower in AUD individuals with past stimulant abuse. Thalamic Cho levels were higher in binge-drinking AUD individuals and in those with longer length of alcohol dependence. MRS-visible metabolite peaks appear to be modulated by variables related to drinking behaviors, suggesting a sensitivity of MRS in tracking and predicting the dynamic course of alcoholism.
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