Evidence map›Paper›PMID 27034950›Full record

ArticleBioMed research international2016

N-(11)C-Methyl-Dopamine PET Imaging of Sympathetic Nerve Injury in a Swine Model of Acute Myocardial Ischemia: A Comparison with (13)N-Ammonia PET.

Weina Zhou, Xiangcheng Wang, Yulin He, Yongzhen Nie, Guojian Zhang, Cheng Wang, Chunmei Wang, Xuemei Wang

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BioMed research international, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. CIRBP protects H9C2 cells against myocardial ischemia through inhibition of NF-κB pathway.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2017
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Weina ZhouDepartment of Nuclear Medicine, Affiliated Hospital of Inner Mongolia Medical University, Hohhot, Inner Mongolia 010050, China.
Xiangcheng WangDepartment of Nuclear Medicine, Affiliated Hospital of Inner Mongolia Medical University, Hohhot, Inner Mongolia 010050, China.
Yulin HeDepartment of Nuclear Medicine, Affiliated Hospital of Inner Mongolia Medical University, Hohhot, Inner Mongolia 010050, China.
Yongzhen NieDepartment of Anesthesiology, Affiliated People's Hospital of Inner Mongolia Medical University, Hohhot, Inner Mongolia 010020, China.
Guojian ZhangDepartment of Nuclear Medicine, Affiliated Hospital of Inner Mongolia Medical University, Hohhot, Inner Mongolia 010050, China.
Cheng WangDepartment of Nuclear Medicine, Affiliated Hospital of Inner Mongolia Medical University, Hohhot, Inner Mongolia 010050, China.
Chunmei WangDepartment of Nuclear Medicine, Affiliated Hospital of Inner Mongolia Medical University, Hohhot, Inner Mongolia 010050, China.
Xuemei WangDepartment of Nuclear Medicine, Affiliated Hospital of Inner Mongolia Medical University, Hohhot, Inner Mongolia 010050, China.
Inner Mongolia Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveUsing a swine model of acute myocardial ischemia, we sought to validate N-(11)C-methyl-dopamine ((11)C-MDA) as an agent capable of imaging cardiac sympathetic nerve injury.

methodsAcute myocardial ischemia was surgically generated in Chinese minipigs. ECG and serum enzyme levels were used to detect the presence of myocardial ischemia. Paired (11)C-MDA PET and (13)N-ammonia PET scans were performed at baseline, 1 day, and 1, 3, and 6 months after surgery to relate cardiac sympathetic nerve injury to blood perfusion.

resultsSeven survived the surgical procedure. The ECG-ST segment was depressed, and levels of the serum enzymes increased. Cardiac uptake of tracer was quantified as the defect volume. Both before and immediately after surgery, the images obtained with (11)C-MDA and (13)N-ammonia were similar. At 1 to 6 months after surgery, however, (11)C-MDA postsurgical left ventricular myocardial defect volume was significantly greater compared to (13)N-ammonia.

conclusionsIn the Chinese minipig model of acute myocardial ischemia, the extent of the myocardial defect as visualized by (11)C-MDA is much greater than would be suggested by blood perfusion images, and the recovery from myocardial sympathetic nerve injury is much slower than the restoration of blood perfusion. (11)C-MDA PET may provide additional biological information during recovery from ischemic heart disease.

Indexed as

Acute Coronary SyndromeAmmoniaAnimalsCardiac Surgical ProceduresContrast MediaDopamineHeartHumansMyocardial IschemiaPositron-Emission TomographyRadiopharmaceuticalsSwineSwine, MiniatureSympathetic Nervous SystemAmmoniaContrast MediaDopamineRadiopharmaceuticals

Identifiers

PMID27034950
PMCPMC4807067
OpenAlexW2286937640

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.