Evidence map›Paper›PMID 27034946›Full record

ArticleBioMed research international2016

Cross-Sectional Nakagami Images in Passive Stretches Reveal Damage of Injured Muscles.

Shih-Ping Lin, Yi-Hsun Lin, Shih-Chen Fan, Bu-Miin Huang, Wei-Yin Lin, Shyh-Hau Wang, K Kirk Shung, Fong-Chin Su, Chia-Ching Wu

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BioMed research international, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 100% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Shih-Ping LinDepartment of Biomedical Engineering, National Cheng Kung University, No. 1, University Road, Tainan 701, Taiwan.
Yi-Hsun LinDepartment of Computer Science and Information Engineering, National Cheng Kung University, No. 1, University Road, Tainan 701, Taiwan.
Shih-Chen FanDepartment of Occupational Therapy, I-Shou University, No. 1, Sec. 1, Syuecheng Road, Dashu District, Kaohsiung, Taiwan.
Bu-Miin HuangDepartment of Cell Biology and Anatomy, National Cheng Kung University, No. 1, University Road, Tainan 701, Taiwan.
Wei-Yin LinDepartment of Biomedical Engineering, National Cheng Kung University, No. 1, University Road, Tainan 701, Taiwan; Institute of Basic Medical Sciences, National Cheng Kung University, No. 1, University Road, Tainan 701, Taiwan.
Shyh-Hau WangDepartment of Computer Science and Information Engineering, National Cheng Kung University, No. 1, University Road, Tainan 701, Taiwan.
K Kirk ShungDepartment of Biomedical Engineering, University of Southern California, Los Angeles, CA 90089, USA.
Fong-Chin SuDepartment of Biomedical Engineering, National Cheng Kung University, No. 1, University Road, Tainan 701, Taiwan; Medical Device and Innovation Center, National Cheng Kung University, No. 1, University Road, Tainan 701, Taiwan.
Chia-Ching WuDepartment of Biomedical Engineering, National Cheng Kung University, No. 1, University Road, Tainan 701, Taiwan; Department of Cell Biology and Anatomy, National Cheng Kung University, No. 1, University Road, Tainan 701, Taiwan; Institute of Basic Medical Sciences, National Cheng Kung University, No. 1, University Road, Tainan 701, Taiwan; Medical Device and Innovation Center, National Cheng Kung University, No. 1, University Road, Tainan 701, Taiwan.
National Cheng Kung University · TWI-Shou University · TWUniversity of Southern California · US

Funding

A Resource on Medical Ultrasonic Transducer TechnologyP41EB002182 · NIBIB · UNIVERSITY OF SOUTHERN CALIFORNIA · PI SHUNG, K KIRK · 2003 to 2016
$13.3M
NIBIB NIH HHS P41 EB002182
6 · The paper itself

Abstract

Muscle strain is still awanting a noninvasive quantitatively diagnosis tool. High frequency ultrasound (HFU) improves image resolution for monitoring changes of tissue structures, but the biomechanical factors may influence ultrasonography during injury detection. We aim to illustrate the ultrasonic parameters to present the histological damage of overstretched muscle with the consideration of biomechanical factors. Gastrocnemius muscles from mice were assembled and ex vivo passive stretching was performed before or after injury. After injury, the muscle significantly decreased mechanical strength. Ultrasonic images were obtained by HFU at different deformations to scan in cross and longitudinal orientations of muscle. The ultrasonography was quantified by echogenicity and Nakagami parameters (NP) for structural evaluation and correlated with histological results. The injured muscle at its original length exhibited decreased echogenicity and NP from HFU images. Cross-sectional ultrasonography revealed a loss of correlation between NP and passive muscle stretching that suggested a special scatterer pattern in the cross section of injured muscle. The independence of NP during passive stretching of injured muscle was confirmed by histological findings in ruptured collagen fibers, decreased muscle density, and increased intermuscular fiber space. Thus, HFU analysis of NP in cross section represents muscle injury that may benefit the clinical diagnosis.

Indexed as

UltrasonographyAnimalsHumansMechanical PhenomenaMiceMuscle Fibers, SkeletalMuscle, Skeletal

Identifiers

PMID27034946
PMCPMC4806670
OpenAlexW2223034019

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.