Evidence map›Paper›PMID 27034916›Full record

ArticleBrain informatics

A semi-automated workflow solution for multimodal neuroimaging: application to patients with traumatic brain injury.

Koon-Pong Wong, Marvin Bergsneider, Thomas C Glenn, Vladimir Kepe, Jorge R Barrio, David A Hovda, Paul M Vespa, Sung-Cheng Huang

Open access · goldAbstract read
In one paragraph

Article in Brain informatics. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
4.1field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it, 21 citations in OpenAlex.

  1. Pooled it
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Koon-Pong WongDepartment of Molecular and Medical Pharmacology, David Geffen School of Medicine at UCLA, Los Angeles, CA USA.
Marvin BergsneiderDepartment of Neurosurgery, David Geffen School of Medicine at UCLA, Los Angeles, CA USA.
Thomas C GlennDepartment of Neurosurgery, David Geffen School of Medicine at UCLA, Los Angeles, CA USA.
Vladimir KepeDepartment of Molecular and Medical Pharmacology, David Geffen School of Medicine at UCLA, Los Angeles, CA USA.
Jorge R BarrioDepartment of Molecular and Medical Pharmacology, David Geffen School of Medicine at UCLA, Los Angeles, CA USA.
David A HovdaDepartment of Molecular and Medical Pharmacology, David Geffen School of Medicine at UCLA, Los Angeles, CA USA ; Department of Neurosurgery, David Geffen School of Medicine at UCLA, Los Angeles, CA USA.
Paul M VespaDepartment of Neurosurgery, David Geffen School of Medicine at UCLA, Los Angeles, CA USA ; Department of Neurology, David Geffen School of Medicine at UCLA, Los Angeles, CA USA.
Sung-Cheng HuangDepartment of Molecular and Medical Pharmacology, David Geffen School of Medicine at UCLA, Los Angeles, CA USA ; Department of Biomathematics, David Geffen School of Medicine at UCLA, Los Angeles, CA USA.
University of California, Los Angeles · US

Funding

VISUALIZING BRAIN A-BETA, TAU /SEROTONIN RECEPTOR DENSITP01AG025831 · NIA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI SMALL, GARY WILLIAM · 2005 to 2010
$7.0M
The effects of glycemic control on post-traumatic brain metabolismP01NS058489 · NINDS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI SUTTON, RICHARD L. · 2009 to 2013
$6.2M
In Vivo Imaging of Post-Traumatic Cerebral Amyloid DepositionR21NS053475 · NINDS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI BERGSNEIDER, MARVIN · 2006 to 2007
$377k
NIA NIH HHS P01 AG025831NINDS NIH HHS P01 NS058489NINDS NIH HHS R21 NS053475
6 · The paper itself

Abstract

Traumatic brain injury (TBI) is a major cause of mortality and morbidity, placing a significant financial burden on the healthcare system worldwide. Non-invasive neuroimaging technologies have been playing a pivotal role in the study of TBI, providing important information for surgical planning and patient management. Advances in understanding the basic mechanisms and pathophysiology of the brain following TBI are hindered by a lack of reliable image analysis methods for accurate quantitative assessment of TBI-induced structural and pathophysiological changes seen on anatomical and functional images obtained from multiple imaging modalities. Conventional region-of-interest (ROI) analysis based on manual labeling of brain regions is time-consuming and the results could be inconsistent within and among investigators. In this study, we propose a workflow solution framework that combined the use of non-linear spatial normalization of structural brain images and template-based anatomical labeling to automate the ROI analysis process. The proposed workflow solution is applied to dynamic PET scanning with

Indexed as

15O-water18F-FDDNPCerebral blood flow (CBF)Magnetic resonance imaging (MRI)Positron emission tomography (PET)Spatial normalizationTraumatic brain injury (TBI)

Identifiers

PMID27034916
PMCPMC4769312
OpenAlexW2344866035

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.