Evidence map›Paper›PMID 27034847›Full record

ReviewNeural plasticity2016

Chronic Stress and Glucocorticoids: From Neuronal Plasticity to Neurodegeneration.

Sheela Vyas, Ana João Rodrigues, Joana Margarida Silva, Francois Tronche, Osborne F X Almeida, Nuno Sousa, Ioannis Sotiropoulos

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Neural plasticity, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 131 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
131citing papers in PubMed, 7 pooled it
10.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

131 citing papers in PubMed, 7 syntheses or guidelines pooled it, 295 citations in OpenAlex.

  1. Pooled it
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  8. Oxytocin as regulator of stress and inflammation in aging.Neuroscience and biobehavioral reviews · 2026
    Review
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  19. Homo sapiens, industrialisation and the environmental mismatch hypothesis.Biological reviews of the Cambridge Philosophical Society · 2026
    Review
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71 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 3 countries.

Sheela VyasLaboratory of Gene Regulation and Adaptive Behaviors, Department of Neuroscience Paris Seine, INSERM U1130, CNRS UMR 8246, Université Pierre et Marie Curie, Paris Cedex 05, France.
Ana João RodriguesLife and Health Sciences Research Institute (ICVS), School of Health Sciences, University of Minho, Campus de Gualtar, 4710-057 Braga, Portugal; ICVS/3B's-PT Government Associate Laboratory, Guimarães, Braga, Portugal.
Joana Margarida SilvaLife and Health Sciences Research Institute (ICVS), School of Health Sciences, University of Minho, Campus de Gualtar, 4710-057 Braga, Portugal; ICVS/3B's-PT Government Associate Laboratory, Guimarães, Braga, Portugal.
Francois TroncheLaboratory of Gene Regulation and Adaptive Behaviors, Department of Neuroscience Paris Seine, INSERM U1130, CNRS UMR 8246, Université Pierre et Marie Curie, Paris Cedex 05, France.
Osborne F X AlmeidaMax Planck Institute of Psychiatry, Kraepelinstrasse 2-10, 80804 Munich, Germany.
Nuno SousaLife and Health Sciences Research Institute (ICVS), School of Health Sciences, University of Minho, Campus de Gualtar, 4710-057 Braga, Portugal; ICVS/3B's-PT Government Associate Laboratory, Guimarães, Braga, Portugal.
Ioannis SotiropoulosLife and Health Sciences Research Institute (ICVS), School of Health Sciences, University of Minho, Campus de Gualtar, 4710-057 Braga, Portugal; ICVS/3B's-PT Government Associate Laboratory, Guimarães, Braga, Portugal.
University of Minho · PTCentre National de la Recherche Scientifique · FRMax Planck Institute of Psychiatry · DENeurosciences Paris-Seine

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Stress and stress hormones, glucocorticoids (GCs), exert widespread actions in central nervous system, ranging from the regulation of gene transcription, cellular signaling, modulation of synaptic structure, and transmission and glial function to behavior. Their actions are mediated by glucocorticoid and mineralocorticoid receptors which are nuclear receptors/transcription factors. While GCs primarily act to maintain homeostasis by inducing physiological and behavioral adaptation, prolonged exposure to stress and elevated GC levels may result in neuro- and psychopathology. There is now ample evidence for cause-effect relationships between prolonged stress, elevated GC levels, and cognitive and mood disorders while the evidence for a link between chronic stress/GC and neurodegenerative disorders such as Alzheimer's (AD) and Parkinson's (PD) diseases is growing. This brief review considers some of the cellular mechanisms through which stress and GC may contribute to the pathogenesis of AD and PD.

Indexed as

Neuronal PlasticityAlzheimer DiseaseAnimalsBrainGlucocorticoidsHumansInflammationParkinson DiseaseRisk FactorsStress, PsychologicalGlucocorticoids

Identifiers

PMID27034847
PMCPMC4806285
OpenAlexW2300528976

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.