ReviewJournal of clinical and experimental dentistry2016
The role of serum biomarkers in the diagnosis and prognosis of oral cancer: A systematic review.
Review in Journal of clinical and experimental dentistry, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Diagnostic Efficacy of Serum Biomarkers for Oral Cancer: An Updated Systematic Review and Meta-Analysis.Asian Pacific journal of cancer prevention : APJCP · 2026Pooled it
- Mass spectrometry-based proteomics profiling of dogs with and without oral diseases: a systematic review.BMC oral health · 2024Pooled it
- Growth differentiation factor 15: a promising biomarker in oral cancer.Journal of the Korean Association of Oral and Maxillofacial Surgeons · 2025Article
- An electrochemical biosensor for the detection of microRNA-31 as a potential oral cancer biomarker.Journal of biological engineering · 2025Article
- Prostate Cancer: A Review of Genetics, Current Biomarkers and Personalised Treatments.Cancer reports (Hoboken, N.J.) · 2024Review
- Article
- Up regulation of serum L fucose glycoprotein as a diagnostic biomarker for dysplasia in oral sub mucous fibrosis patients.Heliyon · 2024Article
- Fast and Sensitive Quantification of AccQ-Tag Derivatized Amino Acids and Biogenic Amines by UHPLC-UV Analysis from Complex Biological Samples.Metabolites · 2022Article
- Serum ceruloplasmin as cancer marker in oral pre-cancers and cancers.Journal of carcinogenesis · 2021Article
- Molecular alterations in oral cancer between tobacco chewers and smokers using serum proteomics.Cancer biomarkers : section A of Disease markers · 2021Article
- Estimation of Salivary 8-Hydroxydeoxyguanosine (8-OHdG) as a Potential Biomarker in Assessing Progression towards Malignancy: A Case-Control Study.Asian Pacific journal of cancer prevention : APJCP · 2020Article
- Identification of GIMAP7 and Rabl3 as Putative Biomarkers for Oral Squamous Cell Carcinoma Through Comparative Proteomic Approach.Pathology oncology research : POR · 2020Article
- Simple and robust polymer-based sensor for rapid cancer detection using serum.Chemical communications (Cambridge, England) · 2019Article
- Changes in the Urinary Proteome in a Patient-Derived Xenograft (PDX) Nude Mouse Model of Colorectal Tumor.Scientific reports · 2019Article
- Influence of dental treatment in place on quality of life in oral cancer patients undergoing chemoradiotherapy.Medicina oral, patologia oral y cirugia bucal · 2018Article
- Nanotechnology: a promising method for oral cancer detection and diagnosis.Journal of nanobiotechnology · 2018Review
- Evolution of oral health in oral cancer patients with and without dental treatment in place: Before, during and after cancer treatment.Journal of clinical and experimental dentistry · 2018Article
- Evaluation of the immunohistochemical expression of oxidative DNA damage marker 8-OHdG in oral cancer.Journal of oral and maxillofacial pathology : JOMFPArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionOral cancer is one of the causes of major morbidity and mortality in the world although incidence varies in the different geographical locations and races. Advances in molecular biology and cancer research have allowed elucidating serum biomarkers to improve diagnostic methods. The aim of this article systematic review is to highlight the utility and clinical value of serum biomarkers in the diagnosis and prognosis of oral cancer. MATERIAL AND
methodsA systematic literature review using PubMed (MEDLINE databases) revealed a total of 140 articles related to this topic. Of those articles, 29 were included in the final review. We included articles published in English in the last five years, developed in human as cases and controls studies, retrospective or prospective studies and specific studies that analyzed a certain biomarker in serum.
resultsAll of the studies include in this systematic review found significant differences in patients. Of those articles included, 2 used biomarkers to determinate cancerous phenotype, 11 mentioned their results were associated with worse prognosis and overall survival, 4 correlated biomarker concentration to clinical stages, 4 concluded it could be a helpful in diagnosis and 8 studies did not find a clear utility of the analysed biomarker. Due to differences in the presentation of data, meta-analysis was not possible.
conclusionsBiomarker use for diagnosis and prognosis is supported by clinical and scientific evidence is relevant. Nevertheless, after selecting a certain biomarker, monitoring protocols should be established in oral and maxillofacial surgeons teams so as we have a correct understanding of biological values. KEY WORDS: Serum biomarkers, oral cancer, diagnosis, prognosis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.