Evidence map›Paper›PMID 27034581›Full record

ArticleGefasschirurgie : Zeitschrift fur vaskulare und endovaskulare Chirurgie : Organ der Deutschen und der Osterreichischen Gesellschaft fur Gefasschirurgie unter Mitarbeit der Schweizerischen Gesellschaft fur Gefasschirurgie

Biodegradable polymeric stents for vascular application in a porcine carotid artery model: English version.

S Kischkel, N Grabow, A Püschel, B Erdle, M Kabelitz, D P Martin, S F Williams, I Bombor, K Sternberg, K-P Schmitz and 2 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Gefasschirurgie : Zeitschrift fur vaskulare und endovaskulare Chirurgie : Organ der Deutschen und der Osterreichischen Gesellschaft fur Gefasschirurgie unter Mitarbeit der Schweizerischen Gesellschaft fur Gefasschirurgie. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.2field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 11 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. The development of carotid stent material.Interventional neurology · 2015
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 2 countries.

S KischkelKlinik und Poliklinik für Allgemeine, Thorax-, Gefäß- und Transplantationschirurgie, Universitätsmedizin Rostock, Schillingallee 70, 18057 Rostock, Germany.
N GrabowInstitut für Biomedizinische Technik, Universitätsmedizin Rostock, Rostock, Germany.
A PüschelKlinik und Poliklinik für Allgemeine, Thorax-, Gefäß- und Transplantationschirurgie, Universitätsmedizin Rostock, Schillingallee 70, 18057 Rostock, Germany.
B ErdleKlinik und Poliklinik für Allgemeine, Thorax-, Gefäß- und Transplantationschirurgie, Universitätsmedizin Rostock, Schillingallee 70, 18057 Rostock, Germany.
M KabelitzKlinik und Poliklinik für Allgemeine, Thorax-, Gefäß- und Transplantationschirurgie, Universitätsmedizin Rostock, Schillingallee 70, 18057 Rostock, Germany.
D P MartinTEPHA, Inc., Lexington, USA.
S F WilliamsTEPHA, Inc., Lexington, USA.
I BomborInstitut für Diagnostische und Interventionelle Radiologie, Universitätsmedizin Rostock, Rostock, Germany.
K SternbergInstitut für Biomedizinische Technik, Universitätsmedizin Rostock, Rostock, Germany.
K-P SchmitzInstitut für Biomedizinische Technik, Universitätsmedizin Rostock, Rostock, Germany.
W SchareckKlinik und Poliklinik für Allgemeine, Thorax-, Gefäß- und Transplantationschirurgie, Universitätsmedizin Rostock, Schillingallee 70, 18057 Rostock, Germany.
C M BüngerKlinik und Poliklinik für Allgemeine, Thorax-, Gefäß- und Transplantationschirurgie, Universitätsmedizin Rostock, Schillingallee 70, 18057 Rostock, Germany ; Klinik für Gefäßmedizin, Vivantes Klinikum Humboldt, Berlin, Germany.
Universitätsmedizin Rostock · DETepha (United States) · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Over the past years the development of biodegradable polymeric stents has made great progress; nevertheless, essential problems must still be solved. Modifications in design and chemical composition should optimize the quality of biodegradable stents and remove the weaknesses. New biodegradable poly-L-lactide/poly-4-hydroxybutyrate (PLLA/P4HB) stents and permanent 316L stents were implantedendovascularly into both common carotid arteries of 10 domestic pigs. At 4 weeks following implantation, computed tomography (CT) angiography was carried out to identify the distal degree of stenosis. The PLLA/P4HB group showed a considerably lower distal degree of stenosis by additional oral application of atorvastatin (mean 39.81 ± 8.57 %) compared to the untreated PLLA/P4HB group without atorvastatin (mean 52.05 ± 5.80 %). The 316L stents showed no differences in the degree of distal stenosis between the group treated with atorvastatin (mean 44.21 ± 2.34 %) and the untreated group (mean 35.65 ± 3.72 %). Biodegradable PLLA/P4HB stents generally represent a promising approach to resolving the existing problems in the use of permanent stents. Restitutio ad integrum is only achievable if a stent is completely degraded.

Indexed as

AtorvastatinBiodegradable stentsCommon carotid arteryPoly(4-hydroxybutyrate)Poly(L-lactide)

Identifiers

PMID27034581
PMCPMC4767847
OpenAlexW70378744

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.