Evidence map›Paper›PMID 27034474›Full record

ArticleArteriosclerosis, thrombosis, and vascular biology2016

Impaired Cholesterol Efflux Capacity of High-Density Lipoprotein Isolated From Interstitial Fluid in Type 2 Diabetes Mellitus-Brief Report.

Johanna Apro, Uwe J F Tietge, Arne Dikkers, Paolo Parini, Bo Angelin, Mats Rudling

Open access · bronzeAbstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Arteriosclerosis, thrombosis, and vascular biology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed
5.3field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 43 citations in OpenAlex.

  1. Article
  2. HDL metabolism and function in diabetes mellitus.Nature reviews. Endocrinology · 2026
    Review
  3. Review
  4. Review
  5. Article
  6. Insulin Resistance, Obesity, and Lipotoxicity.Advances in experimental medicine and biology · 2024
    Review
  7. Article
  8. Review
  9. Review
  10. Review
  11. Review
  12. Article
  13. Article
  14. Review
  15. Review
  16. Review
  17. Review
  18. Article
  19. Coagulatory Defects in Type-1 and Type-2 Diabetes.International journal of molecular sciences · 2019
    Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Johanna AproFrom the Metabolism Unit (J.A., P.P., B.A., M.R.) and KI/AZ Integrated CardioMetabolic Center (J.A., B.A., M.R.), Department of Medicine and Department of Biosciences and Nutrition (J.A., B.A., M.R.), Karolinska Institute, Karolinska University Hospital Huddinge, Stockholm, Sweden. Department of Pediatrics, The University of Groningen, University Medical Center Groningen, Groningen, The Netherlands (U.J.F.T., A.D.); and Division of Clinical Chemistry, Department of Laboratory Medicine, Karolinska Institute at Karolinska University Hospital Huddinge, Stockholm, Sweden (P.P.). johanna.apro@ki.se.
Uwe J F TietgeFrom the Metabolism Unit (J.A., P.P., B.A., M.R.) and KI/AZ Integrated CardioMetabolic Center (J.A., B.A., M.R.), Department of Medicine and Department of Biosciences and Nutrition (J.A., B.A., M.R.), Karolinska Institute, Karolinska University Hospital Huddinge, Stockholm, Sweden. Department of Pediatrics, The University of Groningen, University Medical Center Groningen, Groningen, The Netherlands (U.J.F.T., A.D.); and Division of Clinical Chemistry, Department of Laboratory Medicine, Karolinska Institute at Karolinska University Hospital Huddinge, Stockholm, Sweden (P.P.).
Arne DikkersFrom the Metabolism Unit (J.A., P.P., B.A., M.R.) and KI/AZ Integrated CardioMetabolic Center (J.A., B.A., M.R.), Department of Medicine and Department of Biosciences and Nutrition (J.A., B.A., M.R.), Karolinska Institute, Karolinska University Hospital Huddinge, Stockholm, Sweden. Department of Pediatrics, The University of Groningen, University Medical Center Groningen, Groningen, The Netherlands (U.J.F.T., A.D.); and Division of Clinical Chemistry, Department of Laboratory Medicine, Karolinska Institute at Karolinska University Hospital Huddinge, Stockholm, Sweden (P.P.).
Paolo PariniFrom the Metabolism Unit (J.A., P.P., B.A., M.R.) and KI/AZ Integrated CardioMetabolic Center (J.A., B.A., M.R.), Department of Medicine and Department of Biosciences and Nutrition (J.A., B.A., M.R.), Karolinska Institute, Karolinska University Hospital Huddinge, Stockholm, Sweden. Department of Pediatrics, The University of Groningen, University Medical Center Groningen, Groningen, The Netherlands (U.J.F.T., A.D.); and Division of Clinical Chemistry, Department of Laboratory Medicine, Karolinska Institute at Karolinska University Hospital Huddinge, Stockholm, Sweden (P.P.).
Bo AngelinFrom the Metabolism Unit (J.A., P.P., B.A., M.R.) and KI/AZ Integrated CardioMetabolic Center (J.A., B.A., M.R.), Department of Medicine and Department of Biosciences and Nutrition (J.A., B.A., M.R.), Karolinska Institute, Karolinska University Hospital Huddinge, Stockholm, Sweden. Department of Pediatrics, The University of Groningen, University Medical Center Groningen, Groningen, The Netherlands (U.J.F.T., A.D.); and Division of Clinical Chemistry, Department of Laboratory Medicine, Karolinska Institute at Karolinska University Hospital Huddinge, Stockholm, Sweden (P.P.).
Mats RudlingFrom the Metabolism Unit (J.A., P.P., B.A., M.R.) and KI/AZ Integrated CardioMetabolic Center (J.A., B.A., M.R.), Department of Medicine and Department of Biosciences and Nutrition (J.A., B.A., M.R.), Karolinska Institute, Karolinska University Hospital Huddinge, Stockholm, Sweden. Department of Pediatrics, The University of Groningen, University Medical Center Groningen, Groningen, The Netherlands (U.J.F.T., A.D.); and Division of Clinical Chemistry, Department of Laboratory Medicine, Karolinska Institute at Karolinska University Hospital Huddinge, Stockholm, Sweden (P.P.).
Karolinska University Hospital · SE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivePatients with type 2 diabetes mellitus (T2D) have an increased risk of cardiovascular disease, the mechanism of which is incompletely understood. Their high-density lipoprotein (HDL) particles in plasma have been reported to have impaired cholesterol efflux capacity. However, the efflux capacity of HDL from interstitial fluid (IF), the starting point for reverse cholesterol transport, has not been studied. We here investigated the cholesterol efflux capacity of HDL from IF and plasma from T2D patients and healthy controls. APPROACH AND

resultsHDL was isolated from IF and peripheral plasma from 35 T2D patients and 35 age- and sex-matched healthy controls. Cholesterol efflux to HDL was determined in vitro, normalized for HDL cholesterol, using cholesterol-loaded macrophages. Efflux capacity of plasma HDL was 10% lower in T2D patients than in healthy controls, in line with previous observations. This difference was much more pronounced for HDL from IF, where efflux capacity was reduced by 28% in T2D. Somewhat surprisingly, the efflux capacity of HDL from IF was lower than that of plasma HDL, by 15% and 32% in controls and T2D patients, respectively.

conclusionThese data demonstrate that (1) HDL from IF has a lower cholesterol efflux capacity than plasma HDL and (2) the efflux capacity of HDL from IF is severely impaired in T2D when compared with controls. Because IF comprises the compartment where reverse cholesterol transport is initiated, the marked reduction in cholesterol efflux capacity of IF-HDL from T2D patients may play an important role for their increased risk to develop atherosclerosis.

Indexed as

Biological TransportCase-Control StudiesCholesterol, HDLDiabetes Mellitus, Type 2Extracellular FluidHumansTime FactorsCholesterol, HDLdiabetes mellitus, type 2extracellular fluidhigh-density lipoprotein cholesterollow-density lipoprotein cholesterolmacrophages

Identifiers

PMID27034474
PMCPMC4845764
OpenAlexW2321455953

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.