Evidence map›Paper›PMID 27034453›Full record

ArticleAnnals of the rheumatic diseases2016

Increased prevalence and severity of radiographic hand osteoarthritis in patients with HIV-1 infection associated with metabolic syndrome: data from the cross-sectional METAFIB-OA study.

Anne-Laurence Tomi, Jérémie Sellam, Karine Lacombe, Soraya Fellahi, Manuela Sebire, Caroline Rey-Jouvin, Anne Miquel, Jean-Philippe Bastard, Emmanuel Maheu, Ida K Haugen and 5 more

Registry-linked trialOpen access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Annals of the rheumatic diseases, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02353767 (Evaluation of Liver Fibrosis in HIV-infected Patients With Metabolic Syndrome), which is not on this map. Cited by 26 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed, 2 pooled it
6.9field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02353767 completednot on this map

Evaluation of Liver Fibrosis in HIV-infected Patients With Metabolic Syndrome

TypeobservationalSponsorInstitut de Médecine et d'Epidémiologie Appliquée - Fondation Internationale Léon M'BaRan2011 to 2013Enrolled478ConditionsAbdominal Obesity Metabolic Syndrome, HIV, Liver FibrosisArmsNoninvasive evaluation of liver fibrosis and steatosis
3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 2 syntheses or guidelines pooled it, 52 citations in OpenAlex.

  1. Pooled it
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  14. Obesity promotes lipid accumulation in mouse cartilage-A potential role of acetyl-CoA carboxylase (ACC) mediated chondrocyte de novo lipogenesis.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2022
    Article
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  19. Fatty acids and osteoarthritis: the MOST study.Osteoarthritis and cartilage · 2021
    Observational
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

15 authors at 7 institutions in 3 countries.

Anne-Laurence TomiDepartment of Rheumatology, DHU i2B, Saint-Antoine Hospital, Assistance Publique-Hôpitaux de Paris (AP-HP), Paris, France.
Jérémie SellamDepartment of Rheumatology, DHU i2B, Saint-Antoine Hospital, Assistance Publique-Hôpitaux de Paris (AP-HP), Paris, France.
Karine LacombeSorbonnes Universités, UPMC University Paris 06, INSERM, Institut Pierre Louis d'Épidémiologie et de Santé Publique (IPLESP UMRS 1136), Paris, France.
Soraya FellahiSorbonnes Universités, UPMC University Paris 06, INSERM UMRS_938, DHU i2B, Paris, France.
Manuela SebireDepartment of Infectious Diseases, Saint-Antoine Hospital, AP-HP, Paris, France.
Caroline Rey-JouvinDepartment of Rheumatology, DHU i2B, Saint-Antoine Hospital, Assistance Publique-Hôpitaux de Paris (AP-HP), Paris, France.
Anne MiquelDepartment of Radiology, Saint-Antoine Hospital, AP-HP, Paris, France.
Jean-Philippe BastardSorbonnes Universités, UPMC University Paris 06, INSERM UMRS_938, DHU i2B, Paris, France.
Emmanuel MaheuDepartment of Rheumatology, DHU i2B, Saint-Antoine Hospital, Assistance Publique-Hôpitaux de Paris (AP-HP), Paris, France.
Ida K HaugenDepartment of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway.
David T FelsonClinical Epidemiology Unit, Boston University School of Medicine, Boston, Massachusetts, USA.
Jacqueline CapeauSorbonnes Universités, UPMC University Paris 06, INSERM UMRS_938, DHU i2B, Paris, France.
Pierre-Marie GirardSorbonnes Universités, UPMC University Paris 06, INSERM, Institut Pierre Louis d'Épidémiologie et de Santé Publique (IPLESP UMRS 1136), Paris, France.
Francis BerenbaumDepartment of Rheumatology, DHU i2B, Saint-Antoine Hospital, Assistance Publique-Hôpitaux de Paris (AP-HP), Paris, France.
Jean-Luc MeynardDepartment of Infectious Diseases, Saint-Antoine Hospital, AP-HP, Paris, France.
Sorbonne Université · FRAssistance Publique – Hôpitaux de Paris · FRHôpital Saint-Antoine · FRDélégation Paris 5 · FR657 Oslo · NOBoston University · USInstitut Pierre Louis d‘Épidémiologie et de Santé Publique · FR

Funding

WORK DISABILITY-- PERSONS WITH RHEUMATOID ARTHRITISP60AR047785 · NIAMS · BOSTON UNIVERSITY MEDICAL CAMPUS · PI FELSON, DAVID TOBIN · 2001 to 2016
$18.0M
NIAMS NIH HHS P60 AR047785
6 · The paper itself

Abstract

objectiveTo determine radiographic hand osteoarthritis (HOA) prevalence in patients with HIV-1 infection in comparison with the general population and to address whether metabolic syndrome (MetS) may increase the risk of HOA during HIV-1 infection. PATIENTS: Patients with HIV-1 infection and MetS (International Diabetes Federation, IDF criteria) aged 45-65 years were matched by age and gender to HIV-1-infected subjects without MetS and underwent hand radiographs. Framingham OA cohort was used as general population cohort.

methodsRadiographic HOA was defined as Kellgren-Lawrence (KL) score ≥2 on more than one joint. Radiographic severity was assessed by global KL score and number of OA joints. HOA prevalence was compared with that found in the Framingham study, stratified by age and sex. Logistic and linear regression models were used to determine the risk factors of HOA in patients with HIV-1 infection.

results301 patients (88% male, mean age 53.4±5.0 years) were included, 152 with MetS and 149 without it. Overall, HOA prevalence was 55.5% and was higher for those with MetS than those without it (64.5% vs 46.3%, p=0.002). When considering men within each age group, HOA frequency was greater in patients with HIV-1 infection than the general population (all ages: 55.8% vs 38.7%; p<0.0001), due to the subgroup with MetS (64.9%; p<0.0001), as well as the subgroup without MetS, although not significant (46.6%; p=0.09). Risk of HOA was increased with MetS (OR 2.23, 95% 95% CI 1.26% to 3.96%) and age (OR 1.18, 95% CI 1.12 to 1.25). HOA severity was greater for patients with MetS than those without. HOA was not associated with previous or current exposure to protease inhibitors or HIV infection-related markers.

conclusionsHOA frequency is greater in patients with HIV-1 infection, especially those with MetS, than the general population. TRIAL REGISTRATION NUMBER: NCT02353767.

Indexed as

HIV-1Cross-Sectional StudiesFemaleHand JointsHIV InfectionsHumansMaleMetabolic SyndromeMiddle AgedOsteoarthritisPrevalenceRadiographyRisk FactorsHand OsteoarthritisInfectionsOsteoarthritis

Identifiers

PMID27034453
PMCPMC5482366
OpenAlexW2322703810

What OpenQuestion holds

Textmetadata
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.