Evidence map›Paper›PMID 27034393›Full record

ArticleILAR journal2016

Characterization of New Zealand White Rabbit Gut-Associated Lymphoid Tissues and Use as Viral Oncology Animal Model.

Robyn A Haines, Rebeccah A Urbiztondo, Rashade A H Haynes, Elaine Simpson, Stefan Niewiesk, Michael D Lairmore

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ILAR journal, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.8field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 14 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Human T-cell Leukemia Virus Type 1 andPathogens (Basel, Switzerland) · 2020
    Review
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 2 countries.

Robyn A HainesRobyn A. Haines, DVM, was a PhD student; Rebeccah A. Urbiztondo, DVM, was a Master's student; Rashade A. H. Haynes, PhD, was a postdoctoral fellow; and Elaine Simpson, DVM, was a summer research student in the Department of Veterinary Biosciences at The Ohio State University in Columbus, Ohio. Stefan Niewiesk, PhD, DVM, is professor in the Department of Veterinary Biosciences at The Ohio State University is Columbus, Ohio. Michael D. Lairmore, DVM, PhD, is dean, in the School of Veterinary Medicine at the University of California, Davis in Davis, California.
Rebeccah A UrbiztondoRobyn A. Haines, DVM, was a PhD student; Rebeccah A. Urbiztondo, DVM, was a Master's student; Rashade A. H. Haynes, PhD, was a postdoctoral fellow; and Elaine Simpson, DVM, was a summer research student in the Department of Veterinary Biosciences at The Ohio State University in Columbus, Ohio. Stefan Niewiesk, PhD, DVM, is professor in the Department of Veterinary Biosciences at The Ohio State University is Columbus, Ohio. Michael D. Lairmore, DVM, PhD, is dean, in the School of Veterinary Medicine at the University of California, Davis in Davis, California.
Rashade A H HaynesRobyn A. Haines, DVM, was a PhD student; Rebeccah A. Urbiztondo, DVM, was a Master's student; Rashade A. H. Haynes, PhD, was a postdoctoral fellow; and Elaine Simpson, DVM, was a summer research student in the Department of Veterinary Biosciences at The Ohio State University in Columbus, Ohio. Stefan Niewiesk, PhD, DVM, is professor in the Department of Veterinary Biosciences at The Ohio State University is Columbus, Ohio. Michael D. Lairmore, DVM, PhD, is dean, in the School of Veterinary Medicine at the University of California, Davis in Davis, California.
Elaine SimpsonRobyn A. Haines, DVM, was a PhD student; Rebeccah A. Urbiztondo, DVM, was a Master's student; Rashade A. H. Haynes, PhD, was a postdoctoral fellow; and Elaine Simpson, DVM, was a summer research student in the Department of Veterinary Biosciences at The Ohio State University in Columbus, Ohio. Stefan Niewiesk, PhD, DVM, is professor in the Department of Veterinary Biosciences at The Ohio State University is Columbus, Ohio. Michael D. Lairmore, DVM, PhD, is dean, in the School of Veterinary Medicine at the University of California, Davis in Davis, California.
Stefan NiewieskRobyn A. Haines, DVM, was a PhD student; Rebeccah A. Urbiztondo, DVM, was a Master's student; Rashade A. H. Haynes, PhD, was a postdoctoral fellow; and Elaine Simpson, DVM, was a summer research student in the Department of Veterinary Biosciences at The Ohio State University in Columbus, Ohio. Stefan Niewiesk, PhD, DVM, is professor in the Department of Veterinary Biosciences at The Ohio State University is Columbus, Ohio. Michael D. Lairmore, DVM, PhD, is dean, in the School of Veterinary Medicine at the University of California, Davis in Davis, California.
Michael D LairmoreRobyn A. Haines, DVM, was a PhD student; Rebeccah A. Urbiztondo, DVM, was a Master's student; Rashade A. H. Haynes, PhD, was a postdoctoral fellow; and Elaine Simpson, DVM, was a summer research student in the Department of Veterinary Biosciences at The Ohio State University in Columbus, Ohio. Stefan Niewiesk, PhD, DVM, is professor in the Department of Veterinary Biosciences at The Ohio State University is Columbus, Ohio. Michael D. Lairmore, DVM, PhD, is dean, in the School of Veterinary Medicine at the University of California, Davis in Davis, California.
West Africa Vocational Education · NG

Funding

Role of Inflammation in Tax-mediated TumorigenesisP01CA100730 · NCI · WASHINGTON UNIVERSITY · PI Malachi Griffith · 2003 to 2026
$44.8M
NCI NIH HHS P01 CA100730NCI NIH HHS P01CA100730
6 · The paper itself

Abstract

Rabbits have served as a valuable animal model for the pathogenesis of various human diseases, including those related to agents that gain entry through the gastrointestinal tract such as human T cell leukemia virus type 1. However, limited information is available regarding the spatial distribution and phenotypic characterization of major rabbit leukocyte populations in mucosa-associated lymphoid tissues. Herein, we describe the spatial distribution and phenotypic characterization of leukocytes from gut-associated lymphoid tissues (GALT) from 12-week-old New Zealand White rabbits. Our data indicate that rabbits have similar distribution of leukocyte subsets as humans, both in the GALT inductive and effector sites and in mesenteric lymph nodes, spleen, and peripheral blood. GALT inductive sites, including appendix, cecal tonsil, Peyer's patches, and ileocecal plaque, had variable B cell/T cell ratios (ranging from 4.0 to 0.8) with a predominance of CD4 T cells within the T cell population in all four tissues. Intraepithelial and lamina propria compartments contained mostly T cells, with CD4 T cells predominating in the lamina propria compartment and CD8 T cells predominating in the intraepithelial compartment. Mesenteric lymph node, peripheral blood, and splenic samples contained approximately equal percentages of B cells and T cells, with a high proportion of CD4 T cells compared with CD8 T cells. Collectively, our data indicate that New Zealand White rabbits are comparable with humans throughout their GALT and support future studies that use the rabbit model to study human gut-associated disease or infectious agents that gain entry by the oral route.

Indexed as

AnimalsCD4-Positive T-LymphocytesCD8-Positive T-LymphocytesDisease Models, AnimalIntestine, SmallLymphoid TissueRabbitsgut-associated lymphoid tissue (GALT)human T cell leukemia/lymphoma virus 1 (HTLV-1)intraepithelial lymphocyteslamina propria lymphocyteslymphoid tissuerabbitreviewsmall intestine

Identifiers

PMID27034393
PMCPMC4816124
OpenAlexW2313972774

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.